Abstract:
:Somatostatin-14 (S14) and its precursor, somatostatin-28 (S28), are widely distributed throughout the rat brain, suggesting that they could act as neurotransmitter or neuromodulator in the central nervous system. The present study was undertaken to study the localization of S14 and S28 receptors in the rat brain determined by "in vitro" radioautography. The study performed on slide mounted frozen brain section with iodinated S14 and S28 analogs revealed an identical distribution of binding sites for the two forms of somatostatin. A good correlation could be observed between receptor distribution and immunohistologically localized neuropeptides except for striatum and hypothalamus. However, receptors were not detectable in the hypothalamus and were found in low concentration in the caudate-putamen nucleus, two regions containing high amounts of S28 and S14, suggesting a high occupancy of receptors in these areas by endogenous peptides or an inverse correlation between receptor and peptide concentrations.
journal_name
Peptidesjournal_title
Peptidesauthors
Leroux P,Pelletier Gdoi
10.1016/0196-9781(84)90078-0subject
Has Abstractpub_date
1984-05-01 00:00:00pages
503-6issue
3eissn
0196-9781issn
1873-5169pii
0196-9781(84)90078-0journal_volume
5pub_type
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