Abstract:
:Amyloid deposition in Alzheimer fibrils forms neurotoxic senile plaques in a process that may be modulated by associated proteins. In this work we demonstrate the ability of laminin-1 and laminin-2 to inhibit fibril formation and toxicity on cultured rat hippocampal neurons. We confirm that the laminin-1-derived peptide YFQRYLI inhibits efficiently both fibril formation and neurotoxicity and show that the IKVAV peptide inhibits amyloid neurotoxicity despite its slight inhibition of fibril formation. On other hand, laminin-1 induces disaggregation of preformed fibrils in vitro, characterized as a progressive disassembly of fibrils into protofibrils and further clearance of these latter species, leading to a continual inhibition of amyloid neurotoxicity.
journal_name
Peptidesjournal_title
Peptidesauthors
Morgan C,Bugueño MP,Garrido J,Inestrosa NCdoi
10.1016/s0196-9781(02)00058-xsubject
Has Abstractpub_date
2002-07-01 00:00:00pages
1229-40issue
7eissn
0196-9781issn
1873-5169pii
S019697810200058Xjournal_volume
23pub_type
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