Abstract:
:The release of peptides immunoreactive for a synthetic peptide (V-9-M) contained in the amino-terminal of pro-CCK was examined. The potassium-evoked release of V-9-M immunoreactive peptides from rat cerebral cortical slices in vitro was calcium dependent. Cholecystokinin-secreting rat medullary thyroid carcinoma cells also secreted significant quantities of these peptides. Sephadex column chromatography of the release media from slices and cells showed two V-9-M immunoreactive peptides, one larger and one smaller than V-9-M itself. Previous behavioral studies have suggested that V-9-M has a distinct neuropharmacological profile. These results demonstrate that V-9-M-like peptides are released along with CCK-8 and are consistent with the hypothesis that V-9-M-like peptides may be neurotransmitters or neuromodulators or may be involved in the sorting or transport of CCK-8.
journal_name
Peptidesjournal_title
Peptidesauthors
Cao G,Beinfeld MCdoi
10.1016/0196-9781(92)90011-qsubject
Has Abstractpub_date
1992-11-01 00:00:00pages
1087-90issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(92)90011-Qjournal_volume
13pub_type
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