Abstract：
:[3H]Neurotensin (NT) was found to bind specifically and with high affinity to crude membranes prepared from rat uterus. Scatchard analysis of saturation binding studies indicated that [3H]NT apparently binds to two sites (high affinity Kd 0.5 nM; low affinity Kd 9 nM) with the density of high affinity sites (41 fmoles/mg prot.) being about one-third that of the low affinity sites (100 fmoles/mg prot.). In competition studies, NT and various fragments inhibited [3H]NT binding with the following potencies (approximately IC50): NT 8-13 (0.4 nM), NT 1-13 (4 nM), NT 9-13 (130 nM), NT 1-11, NT 1-8 (greater than 100 microM). Quantitatively similar results were obtained using brain tissue. These findings raise the possibility of a role for NT in uterine function.
journal_name
Peptidesjournal_title
Peptidesauthors
Pettibone DJ,Totaro JAdoi
10.1016/0196-9781(87)90149-5subject
Has Abstractpub_date
1987-11-01 00:00:00pages
1169-72issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(87)90149-5journal_volume
8pub_type
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