Abstract:
:Immunohistochemical studies were conducted on rat brainstem using a specific polyclonal antiserum against the COOH-terminal (25-37) of human amylin. Amylin-immunoreactive cell bodies were observed in the vestibular, cochlear, trapezoid, and inner cerebellar nuclei and in the mesencephalic nucleus of trigeminal nerve. Positive cell bodies were also found in lateral, gigantocellular and magnocellular reticular nuclei. Numerous amylin-immunoreactive nerve fibers were shown in the trigeminal spinal tract, in the solitary area and in the area postrema. Amylin-immunoreactive cell bodies were often surrounded by a network of tyrosine hydroxylase-immunoreactive nerve fibers. These results provide morphologic evidence that amylin may play a role in some discrete sensory functions.
journal_name
Peptidesjournal_title
Peptidesauthors
D'Este L,Casini A,Wimalawansa SJ,Renda TGdoi
10.1016/s0196-9781(00)00325-9subject
Has Abstractpub_date
2000-11-01 00:00:00pages
1743-9issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00325-9journal_volume
21pub_type
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