Demonstration of substance P in aortic nerve afferent fibers by combined use of fluorescent retrograde neuronal labeling and immunocytochemistry.

Abstract:

:Combined use of the intraaxonal retrograde transport of the fluorescent marker 'true blue' with substance P (SP) immunocytochemistry has been used to trace the nodose ganglion projections of SP-containing neurons of the aortic depressor nerve. It has been found that (1) SP immunoreactive (SP-I) cell bodies are clearly demonstrable in clusters in the rostral part of the nodose ganglion without the aid of colchicine pretreatment; (2) 'true blue' is retrogradely transported to the nodose ganglion following its application to the central cut end of the aortic nerve; (3) 'true blue' fluorescence and SP fluorescent immunoreactivity can be visualized in the same tissue section and certain cell bodies in the nodose ganglia contain both SP-I and retrogradely transported 'true blue'. These results indicate that the aortic nerve which projects from the aortic arch baro- and/or chemoreceptors to brainstem vasomotor centers contains SP-I afferent fibers which emanate form the nodose ganglion.

journal_name

Peptides

journal_title

Peptides

authors

Helke CJ,Goldman W,Jacobowitz DM

doi

10.1016/0196-9781(80)90015-7

subject

Has Abstract

pub_date

1980-01-01 00:00:00

pages

359-64

issue

4

eissn

0196-9781

issn

1873-5169

pii

0196-9781(80)90015-7

journal_volume

1

pub_type

杂志文章

相关文献

PEPTIDES文献大全
  • Episodic secretion of ACTH in rats.

    abstract::While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and b...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(86)90216-0

    authors: Carnes M,Brownfield MS,Kalin NH,Lent S,Barksdale CM

    更新日期:1986-03-01 00:00:00

  • Role of D-tryptophan for affinity of MEN 10207 tachykinin antagonist at NK2 receptors.

    abstract::The role of the D-Trp residues in the sequence of the NK2-selective tachykinin antagonist, MEN 10207 (Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Arg-NH2). has been examined by replacement of each D-Trp with either the L-isomer or the residue naturally occurring in the same position of neurokinin A(4-10). The biological activity of...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(91)90053-r

    authors: Rovero P,Astolfi M,Renzetti AR,Patacchini R,Giachetti A,Maggi CA

    更新日期:1991-09-01 00:00:00

  • The Y1 receptor for NPY: a key modulator of the adaptive immune system.

    abstract::Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2006.09.030

    authors: Wheway J,Herzog H,Mackay F

    更新日期:2007-02-01 00:00:00

  • Identification of a stable chemerin analog with potent activity toward ChemR23.

    abstract::Chemerin is a novel peptide that was identified as a natural ligand for ChemR23. As it has been reported to be involved in the regulation of immune responses and adipogenesis, chemerin may have a variety of physiological functions. Chemerin is synthesized as a precursor (prochemerin) and is proteolytically activated a...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2009.05.030

    authors: Shimamura K,Matsuda M,Miyamoto Y,Yoshimoto R,Seo T,Tokita S

    更新日期:2009-08-01 00:00:00

  • Species differences in the efficacy of compounds at the nociceptin receptor (ORL1).

    abstract::Recent studies have identified compounds with reduced efficacy relative to nociceptin/orphanin FQ at the opioid-like receptor ORL1. Utilizing stimulation of [(35)S]GTPgammaS binding as in vitro assays, it was determined that both [Phe(1)psi(CH(2)-NH)Gly(2)]N/OFQ(1-13)NH(2) and the hexapeptide Ac-RYYRIK-NH(2) act as pa...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(00)00253-9

    authors: Burnside JL,Rodriguez L,Toll L

    更新日期:2000-07-01 00:00:00

  • Conformational states of the corticotropin releasing factor 1 (CRF1) receptor: detection, and pharmacological evaluation by peptide ligands.

    abstract::Previous corticotropin releasing factor 1 (CRF1) receptor characterization has been performed using radiolabeled agonists, which bind predominantly the receptor-G-protein complex. The pharmacological profile of other receptor states, and their abundance, remain poorly characterized. Here we investigated the affinity s...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2003.09.002

    authors: Hoare SR,Sullivan SK,Pahuja A,Ling N,Crowe PD,Grigoriadis DE

    更新日期:2003-12-01 00:00:00

  • Conformational and dynamic considerations in peptide structure-function studies.

    abstract::Most small peptide hormones and neurotransmitters are highly flexible, conformationally labile molecules in aqueous and other environments. Thus efforts to determine the relationships between conformational properties of these peptides in aqueous and other solvents and their biological activities at membrane receptors...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(82)90095-x

    authors: Hruby VJ,Mosberg HI

    更新日期:1982-05-01 00:00:00

  • Somatostatin-like immunoreactivity is found in dendritic guard cells of human sweat ducts.

    abstract::Somatostatin is reported in a new population of human sweat duct cells. The epithelial content of somatostatin-like immunoreactivity in normal human skin from various sites of the body was investigated using indirect immunofluorescence. With this methodology we found round-to-oval somatostatin-immunoreactive cells sit...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(93)90058-o

    authors: Johansson O,Hilliges M,Wang L

    更新日期:1993-03-01 00:00:00

  • The effects of cysteamine and capsaicin on somatostatin and substance P in medullary nuclei.

    abstract::Administration of the thiol reagent, cysteamine, reduced the somatostatin content (70-80%) in each of the discrete medullary nuclei assayed without altering the substance P content of the same nuclei. In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(83)90016-5

    authors: Helke CJ,Selsky JH

    更新日期:1983-09-01 00:00:00

  • Lunasin, a novel seed peptide for cancer prevention.

    abstract::Carcinogenesis is a multistage process derived from a combination of multiple heritable and environmental factors. It has been reported that populations consuming high levels of soybean products have both lower cancer incidence and mortality rates in the western countries. Lunasin is a novel and promising peptide init...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2008.11.002

    authors: Hernández-Ledesma B,Hsieh CC,de Lumen BO

    更新日期:2009-02-01 00:00:00

  • Somatostatin binding to dissociated cells from rat cerebral cortex.

    abstract::A method has been developed for the study of somatostatin (SS) binding to dissociated cells from rat cerebral cortex. Binding of [125I] [Tyr11]SS to cells obtained by mechanical dissociation of rat cerebral cortex was dependent on time and temperature, saturable, reversible and highly specific. Under conditions of equ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(90)90138-u

    authors: Colas B,Prieto JC,Arilla E

    更新日期:1990-11-01 00:00:00

  • Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins.

    abstract::The antibacterial activity of peptides without disulfide bridges, spanning the carboxy-terminal segment of arthropod defensins, has been investigated. Although all the peptides have net positive charges, they exhibited varying antibacterial potencies and spectra. Atomic force and fluorescence microscopic analyses indi...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2006.06.010

    authors: Varkey J,Singh S,Nagaraj R

    更新日期:2006-11-01 00:00:00

  • Urotensin II inhibits the proliferation but not the differentiation of cardiac side population cells.

    abstract::Urotensin II (UII) induces the development of cardiac remodeling and atherosclerosis by promoting hypertrophy of cardiomyocytes and mitogenesis of fibroblasts and vascular smooth muscle cells. But its effect on cardiac side population cells (CSPs), one of somatic stem cells, is unclear. The present study examined the ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2011.01.024

    authors: Gong H,Ma H,Liu M,Zhou B,Zhang G,Chen Z,Jiang G,Yan Y,Yang C,Kanda M,Wu J,Yuan J,Li L,Nagai T,Komuro I,Ge J,Zou Y

    更新日期:2011-05-01 00:00:00

  • Characterization of a CCAAT-enhancer element of trefoil factor family 2 (TFF2) promoter in MCF-7 cells.

    abstract::Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2003.11.022

    authors: Chi AL,Lim S,Wang TC

    更新日期:2004-05-01 00:00:00

  • Altered alertness of vasopressin-secreting transgenic mice.

    abstract::We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(95)02047-0

    authors: Miller M,Haroutunian V,Wiltshire-Clement M

    更新日期:1995-01-01 00:00:00

  • A surfactin cyclopeptide of WH1fungin used as a novel adjuvant for intramuscular and subcutaneous immunization in mice.

    abstract::WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2012.08.021

    authors: Gao Z,Wang S,Qi G,Pan H,Zhang L,Zhou X,Liu J,Zhao X,Wu J

    更新日期:2012-11-01 00:00:00

  • Non-associative learning and anxiety in rats treated with a single systemic administration of the gastrin-releasing peptide receptor antagonist RC-3095.

    abstract::The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, L...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2005.06.006

    authors: Martins MR,Reinke A,Valvassori SS,Machado RA,Quevedo J,Schwartsmann G,Roesler R

    更新日期:2005-12-01 00:00:00

  • Immunohistochemical staining of endomorphin 1 and 2 in the immune cells of the spleen.

    abstract::Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2003.11.016

    authors: Seale JV,Jessop DS,Harbuz MS

    更新日期:2004-01-01 00:00:00

  • Elevated plasma levels of immunoreactive urotensin II and its increased urinary excretion in patients with Type 2 diabetes mellitus: association with progress of diabetic nephropathy.

    abstract::Urotensin II (UII) is the most potent vasoconstrictor peptide ever identified. In order to clarify the pathophysiological role of UII in diabetes mellitus, we examined plasma immunoreactive UII levels and urinary excretion of immunoreactive UII in 10 control subjects and 48 patients with Type 2 diabetes mellitus. The ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2004.06.024

    authors: Totsune K,Takahashi K,Arihara Z,Sone M,Murakami O,Ito S,Kikuya M,Ohkubo T,Hashimoto J,Imai Y

    更新日期:2004-10-01 00:00:00

  • Expression of an optimized Argopecten purpuratus antimicrobial peptide in E. coli and evaluation of the purified recombinant protein by in vitro challenges against important plant fungi.

    abstract::Antimicrobial peptides (AMP) have been widely described in several organisms from different kingdoms. We recently designed and evaluated a synthetic version of an AMP isolated and characterized from Argopecten purpuratus hemocytes. This study describes the generation of a chimaeric gene encoding for Ap-S, the use of t...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2011.07.007

    authors: Tapia E,Montes C,Rebufel P,Paradela A,Prieto H,Arenas G

    更新日期:2011-09-01 00:00:00

  • Expression of C-type natriuretic peptide and of its receptor NPR-B in normal and failing heart.

    abstract::C-type natriuretic peptide (CNP) was recently found in the myocardium, but possible insights into differences between atrium and ventricle production are so far lacking. Our aim was to evaluate, in an experimental model of pacing-induced heart failure (HF), plasma and tissue levels of CNP and mRNA expression of the pe...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2008.09.005

    authors: Del Ry S,Cabiati M,Lionetti V,Emdin M,Recchia FA,Giannessi D

    更新日期:2008-12-01 00:00:00

  • Role of neuropeptides in cardiomyopathies.

    abstract::The role of neuropeptides in cardiomyopathy-associated heart failure has been garnering more attention. Several neuropeptides--Neuropeptide Y (NPY), vasoactive intestinal peptide (VIP), calcitonin gene related peptide (CGRP), substance P (SP) and their receptors have been studied in the various types of cardiomyopathi...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2014.08.004

    authors: Dvorakova MC,Kruzliak P,Rabkin SW

    更新日期:2014-11-01 00:00:00

  • Further studies on the pharmacological features of the nociceptin/orphanin FQ receptor ligand ZP120.

    abstract::ZP120 is a nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) ligand. In previous studies, the effects of ZP120 were found to be sensitive to J-113397 in mouse tissues while resistant to UFP-101 in rat tissues. The aim of this study was to further investigate the ZP120 pharmacological profile using mouse and rat pr...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2008.10.001

    authors: Fischetti C,Rizzi A,Gavioli EC,Marzola G,Trapella C,Guerrini R,Petersen JS,Calo G

    更新日期:2009-02-01 00:00:00

  • Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcription.

    abstract::Originally characterized in terms of its gastric acid inhibitory properties, GIP (gastric inhibitory polypeptide) expressed in the upper small intestine, was subsequently shown to exert strong glucose-dependent insulin-releasing properties. This action is generally attributed to GIP(1-42) and, so far, no evidence for ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(95)00090-7

    authors: Fehmann HC,Göke B

    更新日期:1995-01-01 00:00:00

  • Tachykinergic afferents to the rat arcuate nucleus. A combined immunohistochemical and retrograde tracing study.

    abstract::The location of the cells giving rise to the tachykinergic innervation of the rat arcuate nucleus was studied by combining immunohistochemistry and retrograde axonal transport of a protein-gold complex (WGA-ApoHRP-gold). Small volumes (20 nl) of this marker were injected into the arcuate nucleus of the rat. Twenty-fou...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(93)90042-f

    authors: Magoul R,Onteniente B,Benjelloun W,Tramu G

    更新日期:1993-03-01 00:00:00

  • Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation.

    abstract::Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroven...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(03)00044-5

    authors: Yang S,Kawamura Y,Yoshikawa M

    更新日期:2003-02-01 00:00:00

  • Differential distribution of two molecular forms of gonadotropin-releasing hormone in discrete brain areas of goldfish (Carassius auratus).

    abstract::Two molecular forms of gonadotropin-releasing hormone (GnRH) were identified in the extracts of various brain areas, spinal cord and pituitary in female and male goldfish and had chromatographic and immunological properties similar to [His5, Trp7, Tyr8]-GnRH (cGnRH-II) and [Trp7,Leu8]-GnRH (sGnRH). Radioimmunoassay us...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(88)90174-x

    authors: Yu KL,Sherwood NM,Peter RE

    更新日期:1988-05-01 00:00:00

  • Attenuation of the anorectic effects of glucagon, cholecystokinin, and bombesin by the amylin receptor antagonist CGRP(8-37).

    abstract::The anorectic effect of IP injection of amylin (1 microgram/kg) was abolished by simultaneous IP injection of the amylin receptor antagonist calcitonin gene-related peptide-(8-37) [CGRP(8-37), 10 micrograms/kg]. The IP injection of pancreatic glucagon (400 micrograms/kg) at dark onset also reduced food intake in 24-h ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(95)02046-2

    authors: Lutz TA,Del Prete E,Szabady MM,Scharrer E

    更新日期:1996-01-01 00:00:00

  • Human mast cell proteases hydrolyze neurotensin, kinetensin and Leu5-enkephalin.

    abstract::Purified mast cell carboxypeptidase cleaved the C-terminal leucines from Leu5-enkephalin (Leu-ENK), neurotensin (NT), and kinetensin (KT), with Km values of 36, 16, and 15 microM, and kcat values of 44, 51, and 53 s-1, respectively. To better predict potential in vivo hydrolysis products generated by mast cell proteas...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(91)90049-u

    authors: Goldstein SM,Leong J,Bunnett NW

    更新日期:1991-09-01 00:00:00

  • In situ hybridization--visualization and quantitation of genetic expression in mammalian brain.

    abstract::In situ hybridization techniques have been developed that quantitate the relative levels of specific mRNAs in individual cell types of a heterogeneous tissue, the mammalian brain. Here, we discuss those special procedures and precautions necessary for hybridizing radiolabeled probes to developing and adult brain mRNAs...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(85)90139-1

    authors: Griffin WS,Morrison MR

    更新日期:1985-01-01 00:00:00