Abstract:
:The bursa of Fabricius (BF) is acknowledged as central humoral immune organ unique to birds. Our purpose was to identify the potential function of a novel bursal-derived bioactive peptide. A bursal septpeptide (BSP-I), EPASGMM, first isolated from BF, reduced MCF and Hela tumor cells proliferation, and enhanced antitumor factor p53 luciferase activity and protein expression. Further, we found the significantly immune inducing function of BSP-I on antigen-specific immune response in BALB/c mice intraperitoneally immunized with inactivated avian influence virus (AIV, H(9)N(2) subtype) vaccine, including of enhancing the antibody (IgG, the isotypes IgG1 and IgG2a) production, and stimulating cytokines IL-4 and IFN-γ level, and inducing T cell immunophenotyping and lymphocyte proliferation. These results suggested that as the bioactive peptide from avian humoral immune system, various biological function of BSP-I may have far-reaching implication on immune system significance, which might provide novel insight on linking between humoral immune system and development of effective immunotherapeutic strategies for treating human cancers diseases.
journal_name
Peptidesjournal_title
Peptidesauthors
Feng X,Liu T,Wang F,Cao R,Zhou B,Zhang Y,Mao X,Chen P,Zhang Hdoi
10.1016/j.peptides.2011.04.020subject
Has Abstractpub_date
2011-06-01 00:00:00pages
1103-9issue
6eissn
0196-9781issn
1873-5169pii
S0196-9781(11)00169-0journal_volume
32pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The first member of the periviscerokinin peptide family in Locusta migratoria was identified by post-source decay fragmentation on a MALDI-TOF mass spectrometer using a single neurohemal organ only. The primary sequence of this decapeptide, code-named Lom-PVK, is Ala-Ala-Gly-Leu-Phe-Gln-Phe-Pro-Arg-Val-NH(2). Unlike t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00669-6
更新日期:2002-04-01 00:00:00
abstract::Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.005
更新日期:2004-11-01 00:00:00
abstract::A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90230-m
更新日期:1991-11-01 00:00:00
abstract::Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2003.11.016
更新日期:2004-01-01 00:00:00
abstract::The effects of atrial natriuretic factor (ANF) on [3H]norepinephrine ([3H]NE) release evoked by a sodium-free medium (SFM) were studied. Experiments were performed in rat adrenal medulla slices incubated in vitro. Results showed that [3H]NE release evoked by the omission of Na+ was decreased by 10 nM ANF. In addition,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90100-7
更新日期:1994-01-01 00:00:00
abstract::Pharmacological experiments suggest that satiation associated with intestinal infusion of several nutrients is mediated by CCK-A receptors. Otsuka Long-Evans Tokushima Fatty, (OLETF), rats do not express CCK-A receptors and are insensitive to the satiation-producing effects of exogenous CCK. To further evaluate the ro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00461-2
更新日期:2001-08-01 00:00:00
abstract::Food deprivation and adrenalectomy are associated with low concentrations of leptin in blood and the absence of obesity. Because leptin is known to cross the blood-brain barrier (BBB) by a saturable transport system, we examined whether fasting and adrenalectomy (ADX) also act at the BBB. Multiple-time regression anal...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00195-9
更新日期:2000-05-01 00:00:00
abstract::Hepcidin is a peptide hormone regulating iron metabolism, the dyshomeostasis of which has been implicated in dementia. Yet, data on hepcidin status in dementia are scanty, limited to Alzheimer's disease (AD) and inconsistent due to methodological problems with its determination using immunoassays and/or lack of homoge...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2019.170169
更新日期:2019-12-01 00:00:00
abstract::The oligopeptide transporter (PepT1) is located on the brush-border membrane of the intestinal epithelium which has been regarded as a mediator of protein absorption. Here, we cloned and characterized PepT1 genes from diploid (red crucian carp), triploid and tetraploid fish. Then, the PepT1 expression pattern in diffe...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.12.017
更新日期:2014-02-01 00:00:00
abstract::To evaluate the effects of exogenous ghrelin or obestatin on intestinal injury and accompanying pulmonary injury, intestinal ischemia-reperfusion (I/R) was induced in rats by obstructing the superior mesenteric artery for 60min, whereas laparotomy was performed in the sham group. At the beginning of the 90-min reperfu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.04.014
更新日期:2015-09-01 00:00:00
abstract::We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2004.11.034
更新日期:2005-10-01 00:00:00
abstract::Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00021-6
更新日期:1996-01-01 00:00:00
abstract::Baboons received a 5-minute intravenous infusion of either saline or bombesin (BBS; 1-4 micrograms/kg) following 3 1/2 or 16 1/2 hours of food deprivation and were then allowed to eat for 30 minutes. Plasma insulin was significantly elevated following five minutes of BBS infusion, but there was no change of plasma glu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90019-0
更新日期:1983-09-01 00:00:00
abstract::Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00508-3
更新日期:2001-11-01 00:00:00
abstract::We have developed a semi-intact preparation-consisting of an isolated oviduct with abdominal ganglia VII and VIII intact and attached-with which to characterize the effects on oviduct contraction, of peptides that are bath applied to CNS tissues. The work presented here offers a qualitative analysis of the central eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00173-0
更新日期:2002-11-01 00:00:00
abstract::I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00182-4
更新日期:1997-01-01 00:00:00
abstract::The distribution of FMRFamide-like-immunoreactive peptides was investigated in the brain and pituitary of the elasmobranch fish Scyliorhinus canicula using the indirect immunofluorescence technique. FMRFamide-immunoreactive cells and fibers were mainly observed in the telencephalon and the diencephalon, while other br...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90214-a
更新日期:1991-11-01 00:00:00
abstract::Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then e...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.01.001
更新日期:2006-07-01 00:00:00
abstract::Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. T...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.08.002
更新日期:2007-10-01 00:00:00
abstract::Antimicrobial peptides (AMPs) and mucins are components of airway secretions and both contribute to the innate host defense system. At neutral pH, AMPs are positively charged, mucins negatively. It was the aim of the study to test whether these opposite charges result in interactions between AMPs and mucins. We measur...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.07.018
更新日期:2006-12-01 00:00:00
abstract::In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90169-4
更新日期:1994-01-01 00:00:00
abstract::To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(95)00024-e
更新日期:1995-01-01 00:00:00
abstract::Due to recent emergence of fungal pathogens resistant to current antifungal therapies, several studies have been focused on screening of plant peptides to find novel compounds having antifungal activities. Here, a novel antifungal plant peptide, with molecular mass of 1230 Da was purified from fruits of Trapa natans b...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.06.020
更新日期:2011-08-01 00:00:00
abstract::Salusins originally identified using bioinformatics analyses have been shown to act on the cardiovascular and endocrine systems. Although the hypotensive activity of salusin-alpha is limited, it exerts a significant anti-atherosclerotic effect via suppression of foam cell formation in human monocyte-derived macrophage...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.08.015
更新日期:2008-12-01 00:00:00
abstract::This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfact...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.03.031
更新日期:2012-06-01 00:00:00
abstract::alpha-MSH stimulates steroid secretion by rat adrenal zona glomerulosa cells and tissues but not fasciculata/reticularis cells when added to in vitro incubations. With glomerulosa cells from control animals on a normal sodium intake, production of corticosterone was significantly stimulated at an alpha-MSH concentrati...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80026-5
更新日期:1981-07-01 00:00:00
abstract::Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.014
更新日期:2012-02-01 00:00:00
abstract::The functional role of the C-terminal amide group (-CONH2) of the molluscan regulatory peptide FMRFamide has been examined in two sets of analogues based on FnLKFamide and FnLRFamide (nL = norleucine). In each series the amide group was replaced by -CONHCH3, -CON(CH3)2, -CONHNH2, -COOCH3, -CH2OH, and -COOH. The analog...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90173-2
更新日期:1994-01-01 00:00:00
abstract::Glucagon-like-peptide-1 (GLP-1) is a proglucagon-derived peptide expressed in the intestinal enteroendocrine-L cells and released after meal ingestion. GLP-1 reduces postprandial glycemia not only by its hormonal effects, but also by its inhibitory effects on gastrointestinal motility. Recently, we showed that GLP-1 a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.09.028
更新日期:2011-01-01 00:00:00
abstract::The presence and antimicrobial activity of antimicrobial peptides (AMPs) has been widely recognized as an evolutionary preserved part of the innate immune system. Based on evidence in animal models and humans, AMPs are now positioned as novel anti-infective agents. The current study aimed to evaluate the potential ant...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.05.022
更新日期:2006-11-01 00:00:00