Abstract:
:Endomorphin 1 (EM-1) and EM-2 have been widely reported in the cells of the central nervous system (CNS) but limited research has been done regarding their distribution in the peripheral system. The occurrence of EM-1 and -2 in the spleen as measured by RIA and their ability to mediate immune function imply a role for EMs in this area. The current study examines the localization of EM-1 and -2 in the immune cells of the spleen of male and female rats via an immunohistochemical procedure. In both genders, EM-1 and -2 immunoreactive staining was predominantly present in macrophages and B cells with minimal EM immunoreactive staining in T cells. This is the first evidence of a differential distribution of EM-1 and -2 in cells of the immune system.
journal_name
Peptidesjournal_title
Peptidesauthors
Seale JV,Jessop DS,Harbuz MSdoi
10.1016/j.peptides.2003.11.016subject
Has Abstractpub_date
2004-01-01 00:00:00pages
91-4issue
1eissn
0196-9781issn
1873-5169pii
S0196978103004182journal_volume
25pub_type
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