Visualization of neuropeptides in paraffin-embedded tissue sections of the central nervous system in the decapod crustacean, Penaeus monodon, by imaging mass spectrometry.

abstract：:Intracerebroventricular injection of NPY inhibits epileptiform seizures and seizure-related "wet dog shakes" (WDS) following electrical stimulation of the dentate gyrus or subiculum. This study examined the effects of NPY on seizures and WDS elicited in hippocampal CA3. Like in the other hippocampal regions, NPY signi...

journal_title：Peptides

authors： Klemp K,Woldbye DP

更新日期：2001-03-01 00:00:00

abstract：:The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantif...

journal_title：Peptides

authors： Correa FM,Viswanathan M,Ciuffo GM,Tsutsumi K,Saavedra JM

更新日期：1995-01-01 00:00:00

abstract：:Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...

journal_title：Peptides

authors： Benter IF,Diz DI,Ferrario CM

更新日期：1993-07-01 00:00:00

abstract：:Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...

journal_title：Peptides

authors： Harville BA,Dreyfus LA

更新日期：1996-01-01 00:00:00

abstract：:We compared the in vitro and in vivo biological activities of PG-KII (pGlu-Pro-Asn-Pro-Asp-Glu-Phe-Val-Gly-Leu-Met-NH2), a new peptide belonging to the tachykinin family, related to kassinin, isolated and sequenced from extracts of the skin of the Australian myobatrachid frog Pseudophryne güntheri, with those of the w...

journal_title：Peptides

authors： Improta G,Broccardo M,Severini C,Erspamer V

更新日期：1996-01-01 00:00:00

abstract：:To determine if different subtypes of mu-opioid receptors were involved in antinociception induced by endomorphin-1 and endomorphin-2, the effect of pretreatment with various mu-opioid receptor antagonists beta-funaltrexamine, naloxonazine and 3-methylnaltrexone on the inhibition of the paw-withdrawal induced by endom...

journal_title：Peptides

authors： Sakurada S,Hayashi T,Yuhki M,Fujimura T,Murayama K,Yonezawa A,Sakurada C,Takeshita M,Sato T,Zadina JE,Kastin AJ,Sakurada T

更新日期：2002-05-01 00:00:00

abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...

journal_title：Peptides

authors： Shoji I,Hirose T,Mori N,Hiraishi K,Kato I,Shibasaki A,Yamamoto H,Ohba K,Kaneko K,Morimoto R,Satoh F,Kohzuki M,Totsune K,Takahashi K

更新日期：2010-10-01 00:00:00

abstract：:Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...

journal_title：Peptides

authors： Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

更新日期：1997-01-01 00:00:00

abstract：:The effect of synthetic human calcitonin gene-related peptide (hCGRP) on the isolated and electrically driven left atria of rats were investigated. The peptide at concentrations of 3 X 10(-9)-3 X 10(-7) M produced positive inotropic effects on the left atria in a dose-dependent manner. Verapamil (10(-5) M) and adenosi...

journal_title：Peptides

authors： Satoh M,Oku R,Maeda A,Fujii N,Otaka A,Funakoshi S,Yajima H,Takagi H

更新日期：1986-07-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...

journal_title：Peptides

authors： Lu W,Cai H,Chen Y,Liao X,Zhang L,Ma T,Sun H,Qi Y

更新日期：2020-11-13 00:00:00

abstract：:The amino acid sequence of the vasoactive intestinal polypeptide (VIP) is well conserved between species. Thus, all mammalian VIPs isolated so far, except that of the guinea pig, have the same amino acid sequence. This study describes the isolation and primary structure of sheep brain VIP. The purification was followe...

journal_title：Peptides

authors： Gafvelin G

更新日期：1990-07-01 00:00:00

abstract：:An important question in contemporary sensory neuroscience is how animals perceive their environment and make appropriate behavioral choices based on chemical perceptions. The fruit fly Drosophila melanogaster exhibits robust tastant and odor-evoked behaviors. Understanding how the gustatory and olfactory systems supp...

journal_title：Peptides

authors： Herrero P

更新日期：2012-12-01 00:00:00

abstract：:Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...

journal_title：Peptides

authors： Marco HG,Simek P,Clark KD,Gäde G

更新日期：2013-03-01 00:00:00

abstract：:We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...

journal_title：Peptides

authors： Schiöth HB,Haitina T,Ling MK,Ringholm A,Fredriksson R,Cerdá-Reverter JM,Klovins J

更新日期：2005-10-01 00:00:00

abstract：:Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, a very potent vasodilator, is the predominant ne...

journal_title：Peptides

authors： Deng PY,Li YJ

更新日期：2005-09-01 00:00:00

abstract：:The endangered anuran species, Odorrana ishikawae, is endemic to only two small Japanese Islands, Amami and Okinawa. To assess the innate immune system in this frog, we investigated antimicrobial peptides in the skin using artificially bred animals. Nine novel antimicrobial peptides containing the C-terminal cyclic he...

journal_title：Peptides

authors： Iwakoshi-Ukena E,Ukena K,Okimoto A,Soga M,Okada G,Sano N,Fujii T,Sugawara Y,Sumida M

更新日期：2011-04-01 00:00:00

abstract：:Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...

journal_title：Peptides

authors： Nichols R,Demers LA,Larsen BM,Robinson D,Converso K,Russell MW,Westfall MV

更新日期：2010-11-01 00:00:00

abstract：:Intracerebroventricular injections of rat hypothalamic growth hormone-releasing factor (rhGRF) were examined for effects on food intake in free-feeding rats. It was found that, in picomole doses, rhGRF had a stimulatory effect on food intake. Examination of higher doses of rhGRF revealed a decrease in the facilitatory...

journal_title：Peptides

authors： Vaccarino FJ,Feifel D,Rivier J,Vale W,Koob GF

更新日期：1988-01-01 00:00:00

abstract：:A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possib...

journal_title：Peptides

authors： Van Der Haegen A,Peigneur S,Dyubankova N,Möller C,Marí F,Diego-García E,Naudé R,Lescrinier E,Herdewijn P,Tytgat J

更新日期：2012-03-01 00:00:00

abstract：:Prader-Willi syndrome is characterized by dramatic hyperphagia and morbid obesity, and is associated with a deficiency in basal and meal-stimulated serum pancreatic polypeptide (PP) levels. Intravenous infusions of pancreatic polypeptide (90 min, 50 pmol/kg/h) restored normal serum PP levels, and a regimen of morning ...

journal_title：Peptides

authors： Berntson GG,Zipf WB,O'Dorisio TM,Hoffman JA,Chance RE

更新日期：1993-05-01 00:00:00

abstract：:Angiotensin II (ANG II) receptors were present in the thymus of newborn rats (179 +/- 34 fmol/mg protein). In newborns, binding was predominantly localized in the trabecula, and was selectively displaced by the AT2 ligand CGP 42112A (83-85%) and to a lower extent by the AT1 antagonist losartan (15-17%), indicating a m...

journal_title：Peptides

authors： Corrêa FM,De Oliveira AM,Viswanathan M,Saavedra JM

更新日期：1994-01-01 00:00:00

abstract：:In the rodent cerebellum, PACAP is expressed by Purkinje neurons and PAC1 receptors are present on granule cells during both the development period and in adulthood. Treatment of granule neurons with PACAP inhibits proliferation, slows migration, promotes survival and induces differentiation. PACAP also protects cereb...

journal_title：Peptides

authors： Botia B,Basille M,Allais A,Raoult E,Falluel-Morel A,Galas L,Jolivel V,Wurtz O,Komuro H,Fournier A,Vaudry H,Burel D,Gonzalez BJ,Vaudry D

更新日期：2007-09-01 00:00:00

abstract：:Self-administration of ethanol and food share many common features and Richter hypothesized that an increase in ethanol consumption would decrease feeding to balance the excess calories contained in the ethanol. Previously, we have shown that individual alcohol consumption correlates with neurotransmitter gene express...

journal_title：Peptides

authors： Pickering C,Avesson L,Liljequist S,Lindblom J,Schiöth HB

更新日期：2007-12-01 00:00:00

abstract：:The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...

journal_title：Peptides

authors： Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano A

更新日期：2012-11-01 00:00:00

abstract：:The effects of alpha-neo-endorphin on mouse behavior were investigated by using a multi-dimensional behavioral analyser (Animex II) which classifies animal's movements into nine degrees. The intracerebral injection of alpha-neo-endorphin (30 micrograms) significantly decreased the 1/1, 1/2 and 1/4 sizes of movement (l...

journal_title：Peptides

authors： Ukai M,Kameyama T

更新日期：1984-01-01 00:00:00

abstract：:The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K(+) stimulated release of [(3)H]dopamine (DA) from N.Acc prisms in both rat strains,...

journal_title：Peptides

authors： Lodge DJ,Short JL,Mercer LD,Beart PM,Lawrence AJ

更新日期：2000-03-01 00:00:00

abstract：:The emergence of multidrug-resistant strains of Neisseria gonorrhoeae constitutes a serious threat to public health and necessitates the discovery of new types of antimicrobial agents. Among the 18 clinical isolates of N. gonorrhoeae with susceptible to spectinomycin, ceftriaxone and cefixime, 14 isolates were resista...

journal_title：Peptides

authors： Arpornsuwan T,Buasakul B,Jaresitthikunchai J,Roytrakul S

更新日期：2014-03-01 00:00:00

abstract：:Opiate binding sites in five brain regions were labeled with the mu and delta markers, 3H-morphine and 3H-[D-Ala2,D-leu5]enkephalin, respectively. The highest densities of both 3H-morphine and 3H-DADLE labeled sites are found in striatum and frontal cortex. Hypothalamus and midbrain contain predominantly 3H-morphine l...

journal_title：Peptides

authors： Hewlett WA,Barchas JD

更新日期：1983-11-01 00:00:00

abstract：:We examined the mechanism through which leptin increases Na(+), K(+)-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na(+), K(+)-ATPase activity was measured in the renal cortex and medulla. Leptin (1mug/kgmin) increased Na(+), ...

journal_title：Peptides

authors： Bełtowski J,Wójcicka G,Trzeciak J,Marciniak A

更新日期：2006-12-01 00:00:00