Abstract：
:The effects of alpha-neo-endorphin on mouse behavior were investigated by using a multi-dimensional behavioral analyser (Animex II) which classifies animal's movements into nine degrees. The intracerebral injection of alpha-neo-endorphin (30 micrograms) significantly decreased the 1/1, 1/2 and 1/4 sizes of movement (linear locomotion and rearing) within 15 min after injection. None of the effects were significantly affected by naloxone even at high doses. The results suggest that a behaviorally active site within the alpha-neo-endorphin sequence is capable of quite potent but nonopiate effects.
journal_name
Peptidesjournal_title
Peptidesauthors
Ukai M,Kameyama Tdoi
10.1016/0196-9781(84)90063-9subject
Has Abstractpub_date
1984-01-01 00:00:00pages
129-31issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(84)90063-9journal_volume
5pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spon...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2006.07.026
更新日期：2007-02-01 00:00:00
abstract：:Methods have been developed for the microsurgical interruption of nerve pathways in the wall of the intestine and for the immunohistochemical localization of antigens in whole mounts. These methods have made it possible to determine accurately the distributions and projections of neurons containing different putative ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(81)90022-x
更新日期：1981-01-01 00:00:00
abstract：:The distribution of urotensin I (UI) and corticotropin-releasing factor (CRF) immunoreactive (IR) structures was studied in the central nervous system (CNS) of the white sucker using the peroxidase-antiperoxidase immunocytochemical procedure. The close sequence homology between both peptides resulted in a high degree ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90065-3
更新日期：1986-01-01 00:00:00
abstract：:Recent reports suggest that arginine vasopressin (AVP) may be an endogenous antipyretic peptide and a mediator of febrile convulsions [10,12]. The spontaneously seizing Mongolian gerbil was used to investigate the thermoregulatory, behavioral and seizure modulatory effects of AVP. Injection of AVP (1.0 and 5.0 microgr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90070-0
更新日期：1983-11-01 00:00:00
abstract：:Human Zonulin, related to the Zonula occludens toxin of Vibrio cholerae, regulates intestinal permeability and is induced in inflammatory disorders of the lower GI tract. Gastroesophageal reflux disease (GERD) is associated with an impairment of epithelial barrier function. Here, we studied expression of zonulin in th...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.03.017
更新日期：2009-06-01 00:00:00
abstract：:We screened nearly 1000 synthetic peptides and found that JAL-AK22 (KYEGHWYPEKPYKGSGFRCIHI), which is derived from the BoxA domain in the Tob1 protein, activates both unfolded and folded proMMP-7. Interestingly, the smaller derivative of JAL-AK22, termed JAL-TA9 (YKGSGFRMI) possessed auto-proteolytic activity and clea...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.03.005
更新日期：2019-06-01 00:00:00
abstract：:Endocrine regulation in vertebrates is critical for the adaptation and regulation of homeostasis. The G protein-coupled receptor (GPCR) signaling transduction system represents one of the most ancient forms of cell surface signaling. Recently, comparative sequence analysis has aided in the identification and pairing o...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2004.05.021
更新日期：2004-10-01 00:00:00
abstract：:The neuropeptide Y system is known to have expanded in early vertebrate evolution. Three neuropeptide Y receptors have been proposed to have existed before the two basal vertebrate tetraploidizations, namely a Y1-like, a Y2-like, and a Y5-like receptor, with their genes in the same chromosomal region. Previously we ha...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.11.007
更新日期：2013-01-01 00:00:00
abstract：:Inferences regarding biosynthesis of LHRH in rats are made from immunocytochemical studies using LHRH antisera with varied and specific binding requirements. Immunoreactive perikarya were observed with antisera that could bind putative large molecular weight precursors of LHRH. No cells were detected with an antiserum...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90096-7
更新日期：1983-11-01 00:00:00
abstract：:The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2020.170352
更新日期：2020-10-01 00:00:00
abstract：:CR 1409, a glutaramic acid derivative with competitive cholecystokinin-antagonistic activity, was administered IP and evaluated in comparison with proglumide (the model CCK-receptor antagonist), gabexate (protease inhibitor) and PGE2 (cytoprotective) on two different models of experimental pancreatitis. Acute pancreat...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90147-6
更新日期：1986-11-01 00:00:00
abstract：:In the present review we reevaluated the experimental and clinical evidence that there is a local renin angiotensin system in the heart as well as the presence of a functional intracrine component which is activated during pathological conditions like heart failure and hypertension. The implications of these findings ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2011.06.018
更新日期：2011-08-01 00:00:00
abstract：:Amyloid deposition in Alzheimer fibrils forms neurotoxic senile plaques in a process that may be modulated by associated proteins. In this work we demonstrate the ability of laminin-1 and laminin-2 to inhibit fibril formation and toxicity on cultured rat hippocampal neurons. We confirm that the laminin-1-derived pepti...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00058-x
更新日期：2002-07-01 00:00:00
abstract：:Angiotensin II binding sites were localized and quantified in individual brain nuclei from single rats by incubation of tissue sections with 1 nM 125I-[Sar1]-angiotensin II, [3H]-Ultrofilm autoradiography, computerized microdensitometry and comparison with 125I-standards. High angiotensin II binding was present in the...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90044-6
更新日期：1986-07-01 00:00:00
abstract：:The cell adhesion molecule, N-cadherin plays a pivotal role in many biological and disease processes. Drugs that modulate N-cadherin function should therefore be useful therapeutic agents. We have used phage display technology to identify amino acid sequences capable of binding to N-cadherin. All of these sequences ha...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.06.025
更新日期：2008-11-01 00:00:00
abstract：:C-type natriuretic peptide (CNP) is expressed in the vascular endothelium. It is not known whether CNP is specifically increased in patients with idiopathic left ventricular systolic dysfunction (ILVDys) with or without overt heart failure, and whether in these patients it is related with indicators of myocardial and/...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.03.002
更新日期：2007-05-01 00:00:00
abstract：:Inhibitors of metallopeptidases may represent new alternatives in the treatment of cardiovascular disease. Recent investigations have linked the hypotensive properties of the metalloendopeptidase 3.4.24.15 (MEP 24.15) inhibitor c-phenylpropyl-alanyl-alanyl-phenylalanyl-para-aminobenzoate (cFP-A-A-F-pAB) to the attenua...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90053-6
更新日期：1992-09-01 00:00:00
abstract：:In the last 10 years, saliva has been increasingly used as a diagnostic fluid and in predictions of disease progression. Leptin and ghrelin are synthesized in several tissues including the salivary glands. The action of ghrelin is antagonistic to that of leptin. This study was undertaken to measure and compare the sal...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.11.008
更新日期：2005-04-01 00:00:00
abstract：:The aim of the present study was to evaluate in hypothalamus and hindbrain of rainbow trout in vitro the effect of leptin treatment on glucosensing capacity and the expression of orexigenic and anorexigenic peptides involved in the control of food intake. In a first experiment, the response of parameters involved in g...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.11.007
更新日期：2011-02-01 00:00:00
abstract：:The term "oxidative stress" indicates a set of chemical reactions unleashed by a disparate number of events inducing DNA damage, lipid peroxidation, protein modification and other effects, which are responsible of altering the physiological status of cells or tissues. Excessive Reactive Oxygen Species (ROS) levels may...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2017.01.011
更新日期：2017-03-01 00:00:00
abstract：:Prothymosin alpha (ProTα), a nuclear protein, plays multiple functions including cell survival. Most recently, we demonstrated that the active 30-amino acid peptide sequence/P30 (amino acids 49-78) in ProTα retains its substantial activity in neuroprotection in vitro and in vivo as well as in the inhibition of cerebra...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.02.022
更新日期：2013-05-01 00:00:00
abstract：:Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.170154
更新日期：2019-12-01 00:00:00
abstract：:Endokinins are novel tachykinins encoded on the human TAC4 and consist of Endokinin A (EKA), B (EKB), C (EKC) and D (EKD). To date, the function of Endokinins in pain processing was not fully understood. Therefore the aim of this study was to investigate the effects of Endokinin A/B (EKA/B, the common C-terminal decap...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.10.013
更新日期：2010-01-01 00:00:00
abstract：:This study presents the binding and functional properties of the mouse NPFF(2) (mNPFF(2)) receptor, in comparison with its human counterpart (hNPFF(2)). Binding experiments were performed by using the NPFF(2) selective radioligand [(3)H]-EYF in membranes from CHO cells transfected with mouse and human NPFF(2) receptor...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.11.020
更新日期：2010-02-01 00:00:00
abstract：:The functional help provided by four cross-linked synthetic peptides from HIV-1 Gag structural proteins was investigated in the mouse model. These peptides, selected upon non-self-criteria, are not predicted as T epitopes by classical prediction methods such as the Rothbard consensus or the amphipathy rule. Priming mi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90055-8
更新日期：1994-01-01 00:00:00
abstract：:Peptides are an important class of molecules with diverse biological activities. Many endogenous peptides, especially neuropeptides and peptide hormones, play critical roles in development and regulating homeostasis. Furthermore, as drug candidates their high receptor selectivity and potent binding leads to reduced of...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2020.170369
更新日期：2020-09-01 00:00:00
abstract：:The aim of our study was to determine whether a meal modifies the antisecretory response induced by PYY and the structural requirements to elicit antisecretory effects of analogue PYY(22-36) for potential antidiarrhea therapy. The variations in short-circuit current (Isc) due to the modification of ionic transport acr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02037-3
更新日期：1995-01-01 00:00:00
abstract：:Androgenic gland hormone (AGH) is known to be responsible for sex differentiation in crustaceans. The amino acid sequence of AGH-active fraction purified from androgenic glands of the terrestrial isopod Armadillidium vulgare was determined by immunoprecipitation employing three types of antibodies raised against diffe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00374-0
更新日期：2001-02-01 00:00:00
abstract：:In experimental models and in humans, somatostatin (SRIF) is able to contract certain vascular structures. The present experiments were designed to assess the capacity of SRIF to contract cultured rat aortic vascular smooth muscle cells (VSMC), and to analyze the possible mechanisms involved. Cells incubated with SRIF...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00083-2
更新日期：1999-01-01 00:00:00
abstract：:Recently, a new serine protease inhibitor family has been described in arthropods. Eight members were purified from locusts and 13 peptides have been identified by cDNA cloning. The peptides share a conserved cysteine array (Cys-Xaa(9-12)-Cys-Asn-Xaa-Cys-Xaa-Cys-Xaa(2-3)-Gly-Xaa(3-6)-Cys-Thr-Xaa(3)-Cys) with nine inhi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.03.005
更新日期：2004-06-01 00:00:00
