Calcitonin gene-related peptide and hypertension.

abstract：:The 41-residue corticotropin releasing factor (CRF) was synthesized by the solid phase method. The synthetic CRF and arginine vasopressin (AVP) were examined for ACTH releasing activity and effects on the release of 5 other pituitary hormones in vivo and in vitro. Injection of the CRF into pharmacologically blocked ra...

journal_title：Peptides

authors： Turkelson CM,Arimura A,Culler MD,Fishback JB,Groot K,Kanda M,Luciano M,Thomas CR,Chang D,Chang JK,Shimizu M

更新日期：1981-01-01 00:00:00

abstract：:A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in...

journal_title：Peptides

authors： Gafvelin G,Andersson M,Dimaline R,Jörnvall H,Mutt V

更新日期：1988-05-01 00:00:00

abstract：:We studied the effects of calcitonin gene-related peptide (CGRP) on ciliary beat frequency (CBF) and electrical properties of canine tracheal epithelium by a photoelectric method and Ussing's short-circuit technique, respectively. CGRP dose dependently increased CBF, an effect that was accompanied by elevation of intr...

journal_title：Peptides

authors： Tamaoki J,Kanemura T,Kobayashi K,Sakai N,Takizawa T

更新日期：1989-09-01 00:00:00

abstract：:We have previously developed an in vitro model of rat brainstem explants. The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine. In this paradigm we investigated the activity of the analg...

journal_title：Peptides

authors： Greco MC,Lisi L,Currò D,Navarra P,Tringali G

更新日期：2014-06-01 00:00:00

abstract：:Cellular actions of nociceptin/orphanin FQ (N/OFQ) resemble those of micro-, delta-, and kappa-opioids, i.e. activation of inwardly rectifying K(+) conductance, inhibition of high-voltage-activated Ca(2+) channel currents, and impediment of neurotransmitter release. Differences in ORL(1) and micro-receptor distributio...

journal_title：Peptides

authors： Moran TD,Abdulla FA,Smith PA

更新日期：2000-07-01 00:00:00

abstract：:The aspartic protease inhibitor (ATBI) purified from a Bacillus sp. is a potent inhibitor of several proteases including recombinant HIV-1 protease, pepsin, and fungal aspartic protease. In this study, we report the cloning, and over expression of a synthetic gene coding for ATBI in Escherichia coli and establish a pu...

journal_title：Peptides

authors： Vathipadiekal V,Umasankar PK,Patole MS,Rao M

更新日期：2010-01-01 00:00:00

abstract：:Injection of capsaicin into the hindpaw has been employed as a model of chemogenic nociception in mice. Intraplantar injection of nociceptin (30-240 pmol) produced a significant and dose-dependent antinociceptive activity in the capsaicin test. The nociceptin N-terminal fragments, (1-11) and (1-13), were also active w...

journal_title：Peptides

authors： Sakurada T,Komatsu T,Moriyama T,Sasaki M,Sanai K,Orito T,Sakurada C,Sakurada S

更新日期：2005-12-01 00:00:00

abstract：:It has been proved that input of specific electroacupuncture (EA) can activate beta-endorphin(beta-EP)ergic and noradrenergic neurons projecting to the rostral ventrolateral medulla (RVL), the latter acting upon the RVL-GABAergic interneurons, thereby produce depressor effect. The present study further shows that: (1)...

journal_title：Peptides

authors： Ku YH,Chang YZ

更新日期：2001-09-01 00:00:00

abstract：:Ethanol (ETOH) has been shown to have pronounced effects on reproductive endocrinology in humans as well as laboratory animals. We have studied the effects of ETOH on the hypothalamic-pituitary-luteinizing hormone (LH) axis, using the male rat as an animal model. In order to better understand the method by which ETOH ...

journal_title：Peptides

authors： Dees WL,Kozlowski GP

更新日期：1984-01-01 00:00:00

abstract：:Two novel peptides, neuromedin U-8 and U-25, eliciting a potent uterus stimulating activity, have been purified and identified in porcine spinal cord. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-ter...

journal_title：Peptides

authors： Minamino N,Sudoh T,Kangawa K,Matsuo H

更新日期：1985-01-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) secreted by amphibian skin represent an important innate immune defense strategy. There are more than 340 species in the family of Ranidae worldwidely, and from which nearly 100 families of AMPs comprising between 8 and 48 amino acid (aa) residues have been characterized. In current work,...

journal_title：Peptides

authors： Zhang S,Guo H,Shi F,Wang H,Li L,Jiao X,Wang Y,Yu H

更新日期：2012-02-01 00:00:00

abstract：:A non-enkephalin containing pentadeca peptide derived from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: Phe-Ala-Glu-Pro-Leu-Pro-Ser-Glu-Glu-Glu-Gly-Glu-Ser-Tyr-Ser (preproenkephalin 237-251) representing the amino portion of peptide B (preproenkephalin 237-268). The sequ...

journal_title：Peptides

authors： Micanovic R,Kruggel W,Ray P,Lewis RV

更新日期：1984-09-01 00:00:00

abstract：:Quantitative receptor autoradiography using Bolton-Hunter iodinated substance P (SP) was used to localize specific sites in the rat hypothalamus. The amount of SP and neurokinin A (NkA) in extracts from discrete areas of the hypothalamus was measured using specific radioimmunoassays. A high density of SP binding sites...

journal_title：Peptides

authors： Larsen PJ,Jessop DS,Chowdrey HS,Mikkelsen JD,Lightman SL

更新日期：1992-07-01 00:00:00

abstract：:The synthesis is described of an analogue of the locust CRF-like diuretic peptide in which methionine in positions 1,3, and 13 is replaced by isosteric methyl-homoserine residues. This analogue has been tested for biological activity on Malpighian tubules in vitro, and feeding behavior in vivo. It is highly active in ...

journal_title：Peptides

authors： Goldsworthy GJ,Chung JS,Simmonds MS,Tatari M,Varouni S,Poulos CP

更新日期：2003-10-01 00:00:00

abstract：:Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied...

journal_title：Peptides

authors： Dale CS,Pagano Rde L,Rioli V,Hyslop S,Giorgi R,Ferro ES

更新日期：2005-03-01 00:00:00

abstract：:We compared the effects of three micro-(DAMGO, DALDA, TNPO) and three delta-(DPDPE, DELT, SNC-80) opioid agonists on arterial blood gas after IV administration in awake sheep. None of the mu agonists altered pO2, pCO2 or pH. All three mu agonists decreased pO2 increased pCO2 and decreased pO2, and this effect was not ...

journal_title：Peptides

authors： Szeto HH,Soong Y,Wu D,Olariu N,Kett A,Kim H,Clapp JF

更新日期：1999-01-01 00:00:00

abstract：:Neuropeptide Y-containing nerve fibers have previously been demonstrated to innervate the mammalian ovary. These nerve fibers innervate primarily the vasculature. In this study we have developed a method for in vivo measurement of the ovary blood flow rate by means of the 133Xe method. Using this technique we measured...

journal_title：Peptides

authors： Jørgensen JC,Sejrsen P

更新日期：1990-05-01 00:00:00

abstract：:The functional help provided by four cross-linked synthetic peptides from HIV-1 Gag structural proteins was investigated in the mouse model. These peptides, selected upon non-self-criteria, are not predicted as T epitopes by classical prediction methods such as the Rothbard consensus or the amphipathy rule. Priming mi...

journal_title：Peptides

authors： Benveniste O,Vaslin B,Dormont D

更新日期：1994-01-01 00:00:00

abstract：:The expression of the relaxin-3 gene, detected as a new member of the insulin superfamily using human genomic databases, is abundantly present in the brain and testis. Intracerebroventricularly (icv) administered relaxin-3 stimulates food intake. Icv administered relaxin (identical to relaxin-2 in humans) affects the ...

journal_title：Peptides

authors： Otsubo H,Onaka T,Suzuki H,Katoh A,Ohbuchi T,Todoroki M,Kobayashi M,Fujihara H,Yokoyama T,Matsumoto T,Ueta Y

更新日期：2010-06-01 00:00:00

abstract：:Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...

journal_title：Peptides

authors： Kitlinska J,Lee EW,Movafagh S,Pons J,Zukowska Z

更新日期：2002-01-01 00:00:00

abstract：:Nervous, endocrine, and immune systems share a large number of regulatory molecules including hormones and neuropeptides. Vasoactive intestinal peptide (VIP) plays an important role in a variety of immunological functions. In the present report, we sorted purified thymocytes of the four major thymic subsets defined by...

journal_title：Peptides

authors： Delgado M,Martínez C,Leceta J,Garrido E,Gomariz RP

更新日期：1996-01-01 00:00:00

abstract：:In the present study, the C-terminus of endomorphin (Tyr(1)-Pro(2)-Trp/Phe(3)-Phe(4)-NH(2), EMs) analogs [Xaa(4)-R]EMs, modified by substitution of a non-aromatic residue for Phe(4) and ending up with -NH-benzyl, were designed to generate an atypical conformationally constrained peptide set. We investigated the effect...

journal_title：Peptides

authors： Yu Y,Shao X,Wang CL,Liu HM,Cui Y,Fan YZ,Liu J,Wang R

更新日期：2007-04-01 00:00:00

abstract：:A peptide designated cicerarin, with an N-terminal amino acid sequence VKSTGRADDDLAVKTKYLPP dissimilar from known proteins and peptides and a molecular mass of 8kDa, was isolated from seeds of the green chickpea Cicer arietinum cv green chickpea. Cicerarin was isolated with a procedure that involved ion exchange chrom...

journal_title：Peptides

authors： Chu KT,Liu KH,Ng TB

更新日期：2003-05-01 00:00:00

abstract：:To identify a minimal peptide ligand that participates in recognition of heparin, we synthesized peptides extending a 29-kDa fragment in the C-terminal heparin binding domain of fibronectin. We obtained evidence that two peptides (designated D5 and D1) exhibit inhibitory activity on binding of the 29-kDa fragment to h...

journal_title：Peptides

authors： Mohri H,Katoh K,Motomura S,Okubo T

更新日期：1996-01-01 00:00:00

abstract：:Salusins originally identified using bioinformatics analyses have been shown to act on the cardiovascular and endocrine systems. Although the hypotensive activity of salusin-alpha is limited, it exerts a significant anti-atherosclerotic effect via suppression of foam cell formation in human monocyte-derived macrophage...

journal_title：Peptides

authors： Sato K,Koyama T,Shichiri M

更新日期：2008-12-01 00:00:00

abstract：:We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...

journal_title：Peptides

authors： Zhao Y,Wang MY,Hao K,Chen XQ,Du JZ

更新日期：2013-06-01 00:00:00

abstract：:Obestatin is a 23-amino-acid peptide originally regarded as an anorexigenic factor. However, most of the subsequent studies failed to confirm the initially reported anorexigenic properties of obestatin. Obestatin is incapable of crossing the blood brain barrier (BBB), which may affect its biological function. Here, we...

journal_title：Peptides

authors： Ren G,He Z,Cong P,Chen H,Guo Y,Yu J,Liu Z,Ji Q,Song Z,Chen Y

更新日期：2013-04-01 00:00:00

abstract：:The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...

journal_title：Peptides

authors： Mahe S,Tome D,Dumontier AM,Desjeux JF

更新日期：1989-01-01 00:00:00

abstract：:A novel protein expressed by entero-endocrine cells of the mouse stomach was named prepromotilin Related Peptide (ppMTLRP) since it shares sequence similarities with the prepromotilin (Tomasetto et al.). The mouse ppMTLRP was found identical to the rat precursor of ghrelin (ppghrelin), an endogenous ligand specific fo...

journal_title：Peptides

authors： Tomasetto C,Wendling C,Rio MC,Poitras P

更新日期：2001-12-01 00:00:00

abstract：:Opioid receptor binding properties of [3H]Tyr-D-Ala-Phe-Phe-NH2 (TAPP) were characterized in rat brain and Chinese hamster ovary (CHO) cells expressing the rat mu-receptor. In rat brain, [3H]TAPP labeled a single class of opioid sites with a dissociation constant (Kd) of 0.31 nM and maximal number of binding sites (Bm...

journal_title：Peptides

authors： Spetea M,Otvös F,Tóth G,Nguyen TM,Schiller PW,Vogel Z,Borsodi A

更新日期：1998-01-01 00:00:00