Abstract:
:Nervous, endocrine, and immune systems share a large number of regulatory molecules including hormones and neuropeptides. Vasoactive intestinal peptide (VIP) plays an important role in a variety of immunological functions. In the present report, we sorted purified thymocytes of the four major thymic subsets defined by CD4 and CD8 phenotypes. We demonstrate by reverse transcription (RT) and polymerase chain reaction (PCR) both VIP and VIP1 receptor gene expression in double positive (CD4+CD8+) and single positive (CD4+CD8-, CD4-CD8+) thymocyte subsets. Double negative thymocytes (CD4-CD8-) lack VIP and VIP1 receptor gene expression.
journal_name
Peptidesjournal_title
Peptidesauthors
Delgado M,Martínez C,Leceta J,Garrido E,Gomariz RPdoi
10.1016/0196-9781(96)00070-8subject
Has Abstractpub_date
1996-01-01 00:00:00pages
803-7issue
5eissn
0196-9781issn
1873-5169pii
0196-9781(96)00070-8journal_volume
17pub_type
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