Attenuated satiation response to intestinal nutrients in rats that do not express CCK-A receptors.

abstract：:Malaria lactate dehydrogenase, a glycolytic enzyme, is a malaria diagnostic target in lateral flow immunochromatographic rapid diagnostic tests. Recombinant Plasmodium yoelii LDH was cloned into the pET-28a vector, expressed and the expressed protein purified from a Ni-NTA affinity matrix. A pan-malarial LDH antibody ...

journal_title：Peptides

authors： Hurdayal R,Achilonu I,Choveaux D,Coetzer TH,Dean Goldring JP

更新日期：2010-04-01 00:00:00

abstract：:The synthesis, purification, and characterization of biotinylated analogues of motilin are reported. The C-terminal of canine motilin was extended by the addition of a cysteine residue, and then biotinylated. Biotinyl motilin was purified by following HPLC and characterized by amino acid analysis. Biotinylation of the...

journal_title：Peptides

authors： Sakai T,Satoh M,Hayashi H,Fujikura K,Sano I,Koyama H,Tatemoto K,Itoh Z

更新日期：1994-01-01 00:00:00

abstract：:Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...

journal_title：Peptides

authors： Yamanaka A,Adachi M,Imai H,Uchiyama T,Inoue M,Islam AT,Kitazawa C,Endo K

更新日期：2006-03-01 00:00:00

abstract：:Acute treatment of rats with haloperidol results in a rapid and transient increase in striatal c-fos mRNA and Fos immunoreactivity. The induction of immediate early genes by haloperidol may be involved in the development of extrapyramidal side effects. L-Prolyl-L-leucyl-glycinamide (PLG, or MIF-1) has been observed to...

journal_title：Peptides

authors： Ott MC,Costain WJ,Mishra RK,Johnson RL

更新日期：2000-02-01 00:00:00

abstract：:Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redun...

journal_title：Peptides

authors： Hillebrand JJ,de Wied D,Adan RA

更新日期：2002-12-01 00:00:00

abstract：:The extractability of neurotensin (NT) from porcine ileal mucosa was studied by comparison of eight extraction procedures. Tissue content of neurotensin-like immunoreactivity was quantitated and characterized by sequence-specific radioimmunoassays and gel filtration chromatography. Homogenization prior to boiling in e...

journal_title：Peptides

authors： Yamashita Y,Holst Pedersen J,Stadil F

更新日期：1987-07-01 00:00:00

abstract：:In an immunohistochemical study, a specific antiserum raised against [D-Ala2]deltorphin-I (DADTI), a highly selective ligand for delta opioid receptors, was used to demonstrate immunoreactive structures in the rat retina. [D-Ala2]Deltorphin-I immunoreactivity occurred in a subpopulation of the retinal amacrine cells s...

journal_title：Peptides

authors： Abe H,Tooyama I,Renda T,Erspamer V,Kimura H

更新日期：1994-01-01 00:00:00

abstract：:Cholecystokinin octapeptides (CCK8s) have been purified from methanol extracts of two brains from each of two Australian marsupials, Tammar Wallaby and Eastern Quoll, containing 3 nmol and 2 nmol of the peptides, respectively. Immunoreactive CCK was concentrated on QMA SepPak cartridges and purified by two successive ...

journal_title：Peptides

authors： Fan ZW,Eng J,Shaw G,Yalow RS

更新日期：1988-03-01 00:00:00

abstract：:Ad lib and intraoral intake tests can separate the effects of drugs on the appetitive and consummatory phases of ingestive behavior. Central angiotensin II increases ad lib intake from water bottles, but its effect on intraoral intake has not been examined. Rats with both lateral intracerebroventricular (i.c.v.) cannu...

journal_title：Peptides

authors： Houpt TA,Corp ES,Berlin R

更新日期：1998-01-01 00:00:00

abstract：:An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...

journal_title：Peptides

authors： Weindl A,Triepel J,Kuchling G

更新日期：1984-01-01 00:00:00

abstract：:Opioid receptor binding properties of [3H]Tyr-D-Ala-Phe-Phe-NH2 (TAPP) were characterized in rat brain and Chinese hamster ovary (CHO) cells expressing the rat mu-receptor. In rat brain, [3H]TAPP labeled a single class of opioid sites with a dissociation constant (Kd) of 0.31 nM and maximal number of binding sites (Bm...

journal_title：Peptides

authors： Spetea M,Otvös F,Tóth G,Nguyen TM,Schiller PW,Vogel Z,Borsodi A

更新日期：1998-01-01 00:00:00

abstract：:A comparison of the conformational characteristics of the related hormones [Nle(15)] gastrin-17 and [Tyr(9)-SO(3)] cholecystokinin-15, in membrane-mimetic solutions of dodecylphosphocholine micelles and water, was undertaken using NMR spectroscopy to investigate the possibility of a structural motif responsible for th...

journal_title：Peptides

authors： Stone SR,Giragossian C,Mierke DF,Jackson GE

更新日期：2007-11-01 00:00:00

abstract：:During a stress response, various neuropeptides are secreted in a spatiotemporally coordinated way in the brain. For a precise understanding of peptide functions in a stress response, it is important to investigate when and where they are released, how they diffuse, and how they are broken down in the brain. In the pa...

journal_title：Peptides

authors： Inutsuka A,Ino D,Onaka T

更新日期：2020-11-24 00:00:00

abstract：:The study was undertaken to investigate the oxidation and reduction of cholecystokinin (CCK) both as pure standards and as endogenous porcine peptides. Furthermore an attempt was made to prevent oxidation of the endogenous porcine peptides in the extraction procedure. CCK-8 and CCK-33 standards were always oxidized in...

journal_title：Peptides

authors： Bacarese-Hamilton AJ,Adrian TE,Chohan P,Antony T,Bloom SR

更新日期：1985-01-01 00:00:00

abstract：:Selective GLP-1 secretagogues represent a novel potential therapy for type 2 diabetes mellitus. This study examined the GLP-1 secretory activity of the ethnomedicinal plant, Fagonia cretica, which is postulated to possess anti-diabetic activity. After extraction and fractionation extracts and purified compounds were t...

journal_title：Peptides

authors： Jafri L,Saleem S,Calderwood D,Gillespie A,Mirza B,Green BD

更新日期：2016-04-01 00:00:00

abstract：:The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...

journal_title：Peptides

authors： Kato J

更新日期：2020-10-01 00:00:00

abstract：:The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...

journal_title：Peptides

authors： Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano A

更新日期：2012-11-01 00:00:00

abstract：:HP-1 is the most abundant human representative of a recently discovered class of neutrophil cystine- and arginine-rich peptides. These peptides have many potentially regulatory activities expressed at nanomolar concentrations. To establish the levels of HP-1 that can accumulate in human lung tumors and nondiseased lun...

journal_title：Peptides

authors： Bateman A,Singh A,Jothy S,Fraser R,Esch F,Solomon S

更新日期：1992-01-01 00:00:00

abstract：:The emergence of new and resistant viruses is a serious global burden. Conventional antiviral therapy with small molecules has led to the development of resistant mutants. In the case of hand, foot and mouth disease (HFMD), the absence of a US-FDA approved vaccine calls for urgent need to develop an antiviral that cou...

journal_title：Peptides

authors： Lalani S,Gew LT,Poh CL

更新日期：2020-11-07 00:00:00

abstract：:Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...

journal_title：Peptides

authors： Takenaka Y,Nakamura F,Usui H,Lipkowski AW,Toth G,Yoshikawa M

更新日期：2003-05-01 00:00:00

abstract：:In the crayfish Astacus leptodactylus, as in several crustacean species, the crustacean hyperglycemic hormone is present as two isoforms differing by the chirality of the third residue, a phenylalanine. In the present work, isoforms synthesized full length by solid-phase peptide synthesis have been purified, refolded,...

journal_title：Peptides

authors： Lebaupain F,Boscameric M,Pilet E,Soyez D,Kamech N

更新日期：2012-03-01 00:00:00

abstract：:Neuropeptide Y (NPY) is one of the most potent stimulants of food intake in mammals, but very little is known about NPY actions in fish. The present study investigated the role of NPY in food intake in the rainbow trout (Oncorhynchus mykiss). Food intake was monitored at different times after intracerebroventricular a...

journal_title：Peptides

authors： Aldegunde M,Mancebo M

更新日期：2006-04-01 00:00:00

abstract：:Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...

journal_title：Peptides

authors： Vieira-da-Motta O,Ribeiro PD,Dias da Silva W,Medina-Acosta E

更新日期：2001-10-01 00:00:00

abstract：BACKGROUND:Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1...

journal_title：Peptides

authors： Onishi S,Kaji T,Yamada W,Nakame K,Machigashira S,Kawano M,Yano K,Harumatsu T,Yamada K,Masuya R,Kawano T,Mukai M,Hamada T,Souda M,Yoshioka T,Tanimoto A,Ieiri S

更新日期：2018-08-01 00:00:00

abstract：:Oxyntomodulin (OXM), a 37-amino acid glucagon-containing peptide produced mainly in intestine and endocrine pancreas, is present in rat plasma and inhibits pentagastrin-stimulated gastric acid secretion in both the anesthetized and the conscious rat. In order to investigate the modifications in acid and water secretio...

journal_title：Peptides

authors： Jarrousse C,Niel H,Audousset-Puech MP,Martinez J,Bataille D

更新日期：1986-01-01 00:00:00

abstract：:The location of the cells giving rise to the tachykinergic innervation of the rat arcuate nucleus was studied by combining immunohistochemistry and retrograde axonal transport of a protein-gold complex (WGA-ApoHRP-gold). Small volumes (20 nl) of this marker were injected into the arcuate nucleus of the rat. Twenty-fou...

journal_title：Peptides

authors： Magoul R,Onteniente B,Benjelloun W,Tramu G

更新日期：1993-03-01 00:00:00

abstract：:DDSDEEN chromatin peptide, after dansylation, was studied for its ability to bind N-CAM protein. The binding causes a quenching of the Dns-peptide fluorescence emission. Dose- and time-dependent binding of Dns-peptide with N-CAM has been shown. Fluorescence quenching is completely lost if the Dns-peptide is subjected ...

journal_title：Peptides

authors： Marsili V,Lupidi G,Berellini G,Calzuola I,Perni S,Cruciani G,Gianfranceschi GL

更新日期：2008-12-01 00:00:00

abstract：:Kisspeptins are biologically active cleavage peptides of the KiSS-1 gene products with important roles in the suppression of tumor metastasis and in the reproduction. The aim of the present study is to clarify changes of the expression of kisspeptins and kisspeptin receptor in the kidney with and without chronic renal...

journal_title：Peptides

authors： Shoji I,Hirose T,Mori N,Hiraishi K,Kato I,Shibasaki A,Yamamoto H,Ohba K,Kaneko K,Morimoto R,Satoh F,Kohzuki M,Totsune K,Takahashi K

更新日期：2010-10-01 00:00:00

abstract：:Various enkephalins (ENK) have been reported to alter heart rate, systemic blood pressure, and respiratory function but with variable results. We previously found that pentobarbital anesthesia reversed the increases in heart rate and systemic arterial blood pressure produced by Leu5-ENK in the dog. We have now studied...

journal_title：Peptides

authors： Sander GE,Giles TD,Kastin AJ,Quiroz AC,Kaneish A,Coy DH

更新日期：1981-01-01 00:00:00

abstract：:Milk is one of the main source of biologically-active peptides that may function as regulatory substances called food hormones. After passing the gut-blood barrier, the μ-opioid receptor agonist and antagonist peptides may become the new factors influencing various functions of the human organism. The aim of the condu...

journal_title：Peptides

authors： Fiedorowicz E,Jarmołowska B,Iwan M,Kostyra E,Obuchowicz R,Obuchowicz M

更新日期：2011-04-01 00:00:00