Abstract:
:Endogenous hemorphins, derived from degradation of the beta-chain of hemoglobin, lower arterial blood pressure and exert an antinociceptive action in experimental models of nociception. Hemopressin, derived from the alpha-chain of hemoglobin, also decreases blood pressure, but its effects on pain have not been studied. In this work, we examined the influence of hemopressin on inflammatory pain. Hemopressin reverted the hyperalgesia induced by either carrageenin or bradykinin when injected concomitantly or 2.5 h after the phlogistic agents. Hemopressin administered systemically also reverted the hyperalgesia induced by carrageenin. Naloxone did not prevent the antinociceptive action of this peptide. These data suggest that hemopressin inhibits peripheral hyperalgesic responses by mechanisms independent of opioid receptor activation.
journal_name
Peptidesjournal_title
Peptidesauthors
Dale CS,Pagano Rde L,Rioli V,Hyslop S,Giorgi R,Ferro ESdoi
10.1016/j.peptides.2004.10.026subject
Has Abstractpub_date
2005-03-01 00:00:00pages
431-6issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(04)00485-1journal_volume
26pub_type
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