Abstract:
:Bombyxin-IV, a molecular species of bombyxin, which is a member of insulin-like heterodimeric peptides of the silkworm Bombyx mori with prothoracicotropic hormone activity, was synthesized. The A- and B-chains of bombyxin-IV containing four and two Cys residues, respectively, were first synthesized separately by solid phase chemistry using Boc protocol. Then they were coupled by stepwise removal of two different protecting groups at the cysteinyl thiols for semiselective formation of disulfide bridges to give bombyxin-IV in 8% yield. The synthetic bombyxin-IV was shown to have chromatographic and biological properties identical with those of natural bombyxin-IV.
journal_name
Peptidesjournal_title
Peptidesauthors
Maruyama K,Nagasawa H,Isogai A,Tamura S,Ishizaki H,Suzuki Adoi
10.1016/0196-9781(90)90126-psubject
Has Abstractpub_date
1990-01-01 00:00:00pages
169-71issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(90)90126-Pjournal_volume
11pub_type
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