Abstract:
:This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/μl, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB.
journal_name
Peptidesjournal_title
Peptidesauthors
Carlini VP,Machado DG,Buteler F,Ghersi M,Ponzio MF,Martini AC,Schiöth HB,de Cuneo MF,Rodrigues AL,de Barioglio SRdoi
10.1016/j.peptides.2012.03.031subject
Has Abstractpub_date
2012-06-01 00:00:00pages
160-5issue
2eissn
0196-9781issn
1873-5169pii
S0196-9781(12)00166-0journal_volume
35pub_type
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