Abstract：
:We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin peptides with high potency. Detailed characterization of the binding properties of the different subtypes suggests that MCRs in early vertebrates had preference for adrenocorticotropic hormone (ACTH) peptides, while the high sensitivity for the shorter proopiomelanocortin (POMC) products, such as the alpha-, beta-, and gamma-melanocyte-stimulating hormone (MSH), has appeared later, perhaps as the MCR subtypes gained more specialized functions. The MCR repertoire shows in general high similarities in their primary structures, while they are however not similar in terms of functional roles. The MCRs serve therefore as an interesting model family to understand the molecular mechanisms of how functions of the genes can diverge during evolution. In this review, we provide an overview of our recent studies on the cloning, expression, pharmacology, 3D modeling, and genomic studies of the MCRs in non-mammalian species.
journal_name
Peptidesjournal_title
Peptidesauthors
Schiöth HB,Haitina T,Ling MK,Ringholm A,Fredriksson R,Cerdá-Reverter JM,Klovins Jdoi
10.1016/j.peptides.2004.11.034subject
Has Abstractpub_date
2005-10-01 00:00:00pages
1886-900issue
10eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00276-7journal_volume
26pub_type
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