Abstract：
:Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human traits and health. Here, we carefully examined the publicly available genomic and protein sequence databases of the archaic hominins (Neanderthal and Denisova) to draw up the catalog of coding variations in GPCRs for peptide ligands, in comparison with living humans. We then searched in the literature the functional changes, phenotypes and risk of disease possibly associated with the detected variants. Our survey suggests that Neanderthal and Denisovan hominins were likely prone to lower risk of obesity, to enhanced platelet aggregation in response to thrombin, to better response to infection, to less anxiety and aggressiveness and to favorable sociability. While some archaic variants were likely advantageous in the past, they might be responsible for maladaptive disorders today in the context of modern life and/or specific regional distribution. For example, an archaic haplotype in the neuromedin receptor 2 is susceptible to confer risk of diabetic nephropathy in type 1 diabetes in present-day Europeans. Paying attention to the pharmacological properties of some of the archaic variants described in this study may be helpful to understand the variability of therapeutic efficacy between individuals or ethnic groups.
journal_name
Peptidesjournal_title
Peptidesauthors
Mata X,Renaud G,Mollereau Cdoi
10.1016/j.peptides.2019.170154subject
Has Abstractpub_date
2019-12-01 00:00:00pages
170154eissn
0196-9781issn
1873-5169pii
S0196-9781(19)30132-9journal_volume
122pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:The puromycin-sensitive aminopeptidase (ApPS) is a zinc metallopeptidase involved in the degradation of neuropeptides. Putative catalytic residues of the enzyme, Cys146, Glu338, and Lys396 were mutated, and the resultant mutant enzymes characterized. ApPS C146S exhibited normal catalytic activity, ApPS E338A exhibited...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.07.012
更新日期：2003-09-01 00:00:00
abstract：:Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.03.003
更新日期：2018-05-01 00:00:00
abstract：:The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00122-9
更新日期：1999-01-01 00:00:00
abstract：:This paper reviews aspects of NPY research that were emerging in 1985, shortly after the isolation and characterization of the peptide. NPY had become known for its widespread distribution especially in the central and peripheral nervous systems, but also in the gastro-intestinal and respiratory tracts and in fibers i...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2004.02.013
更新日期：2004-03-01 00:00:00
abstract：:By using specific antibodies and radioimmunological and immunohistochemical methods, we here show that neuropeptide FF (NPFF) occurs in cervical and lumbar dorsal root ganglia cells. Levels in the ganglia were low because they were detectable only after colchicine treatment or after unilateral dorsal rhizotomy. Simila...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00039-x
更新日期：1999-01-01 00:00:00
abstract：:[3H]Neurotensin (NT) was found to bind specifically and with high affinity to crude membranes prepared from rat uterus. Scatchard analysis of saturation binding studies indicated that [3H]NT apparently binds to two sites (high affinity Kd 0.5 nM; low affinity Kd 9 nM) with the density of high affinity sites (41 fmoles...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90149-5
更新日期：1987-11-01 00:00:00
abstract：:The striatum is richly innervated by both enkephalinergic and dopaminergic neurons, providing an anatomic framework from which intimate functional interrelationships between these neuronal systems may be postulated. Accordingly, many functional processes within dopamine neurons have been shown to be modulated by opioi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90014-3
更新日期：1987-05-01 00:00:00
abstract：:Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/s0196-9781(01)00508-3
更新日期：2001-11-01 00:00:00
abstract：:Cone snails have evolved an assortment of venom peptides as an evolutionary strategy for rapid prey immobilization and defence. Earlier studies estimated approximately 100 conopeptides per species. In this study we optimized liquid chromatography and electrospray ionization mass spectrometry for the detection of conop...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.03.019
更新日期：2009-07-01 00:00:00
abstract：:Neuropeptides related to vertebrate tachykinins have been identified in Drosophila and are referred to as drosotachykinins, or DTKs. Two Drosophila G protein-coupled receptors, designated NKD (neurokinin receptor from Drosophila; CG6515) and DTKR (Drosophila tachykinin receptor; CG7887), display sequence similarities ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.10.012
更新日期：2009-03-01 00:00:00
abstract：:Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(88)90131-3
更新日期：1988-07-01 00:00:00
abstract：:Interleukin-1 beta (IL-1β) significantly influences cognitive processes. Treatments which raise the level of IL-1β in the brain impair memory consolidation in contextual fear conditioning. However, the effect of IL-1β on memory reconsolidation has not yet been established. The melanocortin α-melanocyte-stimulating hor...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.07.018
更新日期：2010-11-01 00:00:00
abstract：:In sheep, arginine vasopressin (AVP) and corticotropin-releasing factor (CRF) stimulate adrenocorticotropic hormone (ACTH) secretion. Increased hypothalamic secretion of these peptides at the end of gestation initiates parturition in this species. We hypothesized that CRF and/or AVP content in the fetal hypothalamus i...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)02060-8
更新日期：1996-01-01 00:00:00
abstract：:The aim of the present study was to investigate how suckling influences the plasma levels of oxytocin and vasoactive intestinal peptide in lactating dogs. Blood-samples were drawn from ten lactating beagles during suckling, in week one and week three of the five week long lactation period and the levels of vasoactive ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(87)90002-7
更新日期：1987-05-01 00:00:00
abstract：:Two food-derived ACE inhibitory peptides, Ile-Pro-Pro (IPP) and Leu-Lys-Pro (LKP), may have potential as alternative treatments for treatment of mild- or pre-hypertension. Lack of stability to secretory and intracellular peptidases and poor permeability across intestinal epithelia are typical limiting factors of oral ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2015.05.009
更新日期：2015-09-01 00:00:00
abstract：:CR 1409, a glutaramic acid derivative with competitive cholecystokinin-antagonistic activity, was administered IP and evaluated in comparison with proglumide (the model CCK-receptor antagonist), gabexate (protease inhibitor) and PGE2 (cytoprotective) on two different models of experimental pancreatitis. Acute pancreat...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90147-6
更新日期：1986-11-01 00:00:00
abstract：:It is well known that glucoprivation induces the release of counterregulatory hormones such as glucagon, and that the response is attenuated when the stimuli are repeated. Glucoprivation also activates orexigenic neurons and induces hyperphagic responses, although it remains unclear whether these responses are attenua...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.12.009
更新日期：2011-04-01 00:00:00
abstract：:The term "oxidative stress" indicates a set of chemical reactions unleashed by a disparate number of events inducing DNA damage, lipid peroxidation, protein modification and other effects, which are responsible of altering the physiological status of cells or tissues. Excessive Reactive Oxygen Species (ROS) levels may...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2017.01.011
更新日期：2017-03-01 00:00:00
abstract：:In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(00)00286-2
更新日期：2000-09-01 00:00:00
abstract：:Heat-stable enterotoxin b (STb) of Escherichia coli is a 48-amino acid basic, disulfide-bonded peptide that causes intestinal secretion in experimental animal models. Recent evidence suggests that the in vivo mechanism of STb action involves release of 5-hydroxytryptamine (5-HT) and production of prostaglandin E2 (PGE...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(96)00033-2
更新日期：1996-01-01 00:00:00
abstract：:Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients w...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.12.018
更新日期：2005-05-01 00:00:00
abstract：:Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90026-3
更新日期：1984-07-01 00:00:00
abstract：:Obesity is a chronic inflammatory disease significantly risen worldwide, especially among children. Adipokines, secreted from adipose tissue, are hormones involved in various cellular processes such as energy metabolism and inflammation. Among the others, adiponectin is gaining increasing interest for its insulin-sent...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2014.11.007
更新日期：2015-01-01 00:00:00
abstract：:Bradykinin-potentiating peptides from Bothrops jararaca (Bj) discovered in the early 1960s, were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides belong to a large family of snake venom proline-rich oligopeptides (PROs). One of these peptides, Bj-PRO-9a, was essential for definin...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.016
更新日期：2013-10-01 00:00:00
abstract：:VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90200-7
更新日期：1986-01-01 00:00:00
abstract：:A neuropeptide F (NPF) was isolated from the fruit fly, Drosophila mellanogaster, based on a radioimmunoassay for a gut peptide from the corn earworm, Helicoverpa zea. A partial sequence was obtained from the fly peptide, and a genomic sequence coding for NPF was cloned after inverse polymerase chain reaction and show...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00097-2
更新日期：1999-01-01 00:00:00
abstract：:In the rodent cerebellum, PACAP is expressed by Purkinje neurons and PAC1 receptors are present on granule cells during both the development period and in adulthood. Treatment of granule neurons with PACAP inhibits proliferation, slows migration, promotes survival and induces differentiation. PACAP also protects cereb...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2007.04.013
更新日期：2007-09-01 00:00:00
abstract：:Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.06.010
更新日期：2018-09-01 00:00:00
abstract：:Cationic lytic-type peptides have been studied for clinical application in various infections and cancers. This study aimed to determine the functions of our specially designed lytic peptide. To investigate the functional mechanism at the cell membrane level, we used giant unilayer vesicles (GUVs) mimicking cell membr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.09.015
更新日期：2013-12-01 00:00:00
abstract：:Peptic digestion of bovine hemoglobin at low degree of hydrolysis yields an intermediate peptide fraction exhibiting antibacterial activity against Micrococcus luteus A270, Listeria innocua, Escherichia coli and Salmonella enteritidis after separation by reversed-phase HPLC. From this fraction a pure peptide was isola...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.12.008
更新日期：2005-05-01 00:00:00
