Abstract:
:In the rat small intestine, neurotrophin-3 immunoreactivity was identified in ganglion cells and in processes mostly innervating the mucosa and occasionally the muscle layer and vasculature. The vast majority of neurotrophin-3 immunoreactive neurons contained vasoactive intestinal polypeptide (VIP), but not substance P or related tachykinin (SP/TK). Neurotrophin receptors visualized by pan-trk immunoreactivity were found in numerous ganglion cells of both plexuses and in nerve processes in the intestinal wall. Pan-trk submucosal neurons contained VIP (36%) or SP/TK-IR (47%). Pan-trk myenteric neurons contained VIP-IR (57%) or SP/TK (27%). Our data suggest that neurotrophin-3 and neurotrophin receptors may be involved in the maintenance of enteric neuronal circuits, transmission and phenotypic expression.
journal_name
Peptidesjournal_title
Peptidesauthors
De Giorgio R,Arakawa J,Wetmore CJ,Sternini Cdoi
10.1016/s0196-9781(00)00286-2subject
Has Abstractpub_date
2000-09-01 00:00:00pages
1421-6issue
9eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00286-2journal_volume
21pub_type
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