Differential distribution of two molecular forms of gonadotropin-releasing hormone in discrete brain areas of goldfish (Carassius auratus).


:Two molecular forms of gonadotropin-releasing hormone (GnRH) were identified in the extracts of various brain areas, spinal cord and pituitary in female and male goldfish and had chromatographic and immunological properties similar to [His5, Trp7, Tyr8]-GnRH (cGnRH-II) and [Trp7,Leu8]-GnRH (sGnRH). Radioimmunoassay using different GnRH antisera after high pressure liquid chromatography did not reveal significant peaks of mammalian GnRH, [Gln8]-GnRH and [Tyr3,Leu5,Glu6,Trp7,Lys8]-GnRH in the brain extracts. The proportion of cGnRH-II-like immunoactivity to sGnRH-like immunoactivity was higher in the caudal brain areas compared to the rostral areas. The differential distribution of two GnRH forms suggest that the different GnRH forms may have different physiological functions.






Yu KL,Sherwood NM,Peter RE




Has Abstract


1988-05-01 00:00:00
















  • Biotinyl C-terminal-extended motilin as a biologically active receptor probe.

    abstract::The synthesis, purification, and characterization of biotinylated analogues of motilin are reported. The C-terminal of canine motilin was extended by the addition of a cysteine residue, and then biotinylated. Biotinyl motilin was purified by following HPLC and characterized by amino acid analysis. Biotinylation of the...


    pub_type: 杂志文章


    authors: Sakai T,Satoh M,Hayashi H,Fujikura K,Sano I,Koyama H,Tatemoto K,Itoh Z

    更新日期:1994-01-01 00:00:00

  • Hyperalgesic and edematogenic effects of Secapin-2, a peptide isolated from Africanized honeybee (Apis mellifera) venom.

    abstract::Honeybee stings are a severe public health problem. Bee venom contains a series of active components, including enzymes, peptides, and biogenic amines. The local reactions observed after envenoming include a typical inflammatory response and pain. Honeybee venom contains some well-known polycationic peptides, such as ...


    pub_type: 杂志文章


    authors: Mourelle D,Brigatte P,Bringanti LD,De Souza BM,Arcuri HA,Gomes PC,Baptista-Saidemberg NB,Ruggiero Neto J,Palma MS

    更新日期:2014-09-01 00:00:00

  • Isolation and characterization of Neosartorya fischeri antifungal protein (NFAP).

    abstract::A novel 6.6 kDa antifungal peptide (NFAP) from the culture supernatant of the mold, Neosartorya fischeri (anamorf: Aspergillus fischerianus), and its encoding gene were isolated in this study. NFAP is a small, basic and cysteine-rich protein consisting of 57 amino acid residues. It shows 37.9-50% homology to similar p...


    pub_type: 杂志文章


    authors: Kovács L,Virágh M,Takó M,Papp T,Vágvölgyi C,Galgóczy L

    更新日期:2011-08-01 00:00:00

  • Using reduced amino acid composition to predict defensin family and subfamily: Integrating similarity measure and structural alphabet.

    abstract::Defensins are essentially ancient natural antibiotics with potent activity extending from lower organisms to humans. They can inhibit the growth or virulence of micro-organisms directly or indirectly enhance the host's immune system. The successful prediction of defensin peptides will provide very useful information a...


    pub_type: 杂志文章


    authors: Zuo YC,Li QZ

    更新日期:2009-10-01 00:00:00

  • A comparison of leptin and ghrelin levels in plasma and saliva of young healthy subjects.

    abstract::In the last 10 years, saliva has been increasingly used as a diagnostic fluid and in predictions of disease progression. Leptin and ghrelin are synthesized in several tissues including the salivary glands. The action of ghrelin is antagonistic to that of leptin. This study was undertaken to measure and compare the sal...


    pub_type: 杂志文章


    authors: Aydin S,Halifeoglu I,Ozercan IH,Erman F,Kilic N,Aydin S,Ilhan N,Ilhan N,Ozkan Y,Akpolat N,Sert L,Caylak E

    更新日期:2005-04-01 00:00:00

  • Identification of DU 145 prostate cancer cell proteins that bind to the carboxy-terminal peptide of human PTHrP in vitro.

    abstract::Peptides spanning the range of human parathyroid hormone-related protein (PTHrP) have been shown to bind heat shock protein-70 expressed on the surface of cancer cells with cytoprotective consequences in vitro. The present study focused on identification of intracellular proteins that interact with the carboxy-termina...


    pub_type: 杂志文章


    authors: Grzesiak JJ,Burton DW,Deftos LJ,Bouvet M

    更新日期:2006-07-01 00:00:00

  • Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri.

    abstract::Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...


    pub_type: 杂志文章


    authors: Verdon J,Berjeaud JM,Lacombe C,Héchard Y

    更新日期:2008-06-01 00:00:00

  • Neuropeptides, food intake and body weight regulation: a hypothalamic focus.

    abstract::Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redun...


    pub_type: 杂志文章,评审


    authors: Hillebrand JJ,de Wied D,Adan RA

    更新日期:2002-12-01 00:00:00

  • Characterization of immunoreactive AVP in the ovine hypothalamo-pituitary axis.

    abstract::The aims of these studies were to determine the precise molecular nature of immunoreactive (IR-) vasopressin (AVP) in the ovine hypothalamo-pituitary axis and to examine a possible role for glucocorticoids in regulating both AVP processing and levels in this axis. The IR-AVP in extracts of paraventricular nucleus, med...


    pub_type: 杂志文章


    authors: Shen PJ,Clarke IJ,Funder JW,Smith AI

    更新日期:1993-07-01 00:00:00

  • Characterization of a CCAAT-enhancer element of trefoil factor family 2 (TFF2) promoter in MCF-7 cells.

    abstract::Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...


    pub_type: 杂志文章


    authors: Chi AL,Lim S,Wang TC

    更新日期:2004-05-01 00:00:00

  • Prognostic value of leptin: 6-month outcome in patients with intracerebral hemorrhage.

    abstract::Leptin has recently been discussed as a novel biomarker for the clinical outcome of critical illness. This study aims to investigate the prognostic value of leptin with regard to long-term clinical outcomes in patients with intracerebral hemorrhage. In 50 healthy controls and 92 patients with acute spontaneous basal g...


    pub_type: 杂志文章


    authors: Zhang X,Lu XM,Huang LF,Li X

    更新日期:2013-05-01 00:00:00

  • Central administration of oxytocin reduces hyperalgesia in mice: implication for cannabinoid and opioid systems.

    abstract::The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...


    pub_type: 杂志文章


    authors: Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano A

    更新日期:2012-11-01 00:00:00

  • Effects of cell-type specific leptin receptor mutation on leptin transport across the BBB.

    abstract::The functions of leptin receptors (LRs) are cell-type specific. At the blood-brain barrier, LRs mediate leptin transport that is essential for its CNS actions, and both endothelial and astrocytic LRs may be involved. To test this, we generated endothelia specific LR knockout (ELKO) and astrocyte specific LR knockout (...


    pub_type: 杂志文章


    authors: Hsuchou H,Kastin AJ,Tu H,Markadakis EN,Stone KP,Wang Y,Heymsfield SB,Chua SS Jr,Obici S,Magrisso IJ,Pan W

    更新日期:2011-07-01 00:00:00

  • Behavioral effects of the cyclic cholecystokinin peptide analogue JMV-320.

    abstract::The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance re...


    pub_type: 杂志文章


    authors: Hadjiivanova C,Kehayov R,Petkov VV,Amblard M,Martinez J

    更新日期:1995-01-01 00:00:00

  • Evolutionary conservation of the structural, pharmacological, and genomic characteristics of the melanocortin receptor subtypes.

    abstract::We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...


    pub_type: 杂志文章,评审


    authors: Schiöth HB,Haitina T,Ling MK,Ringholm A,Fredriksson R,Cerdá-Reverter JM,Klovins J

    更新日期:2005-10-01 00:00:00

  • Immunosuppressive activity of hymenistatin I.

    abstract::Hymenistatin I (HS-I), a cyclic octapeptide [c-(-Pro-Pro-Tyr-Val-Pro-Leu-Ile-Ile-)], was synthesized by the solid-phase peptide synthesis method and examined for its immunosuppressive activity in the humoral and cellular immune responses. The peptide activity was tested on cell lines producing various cytokines. The r...


    pub_type: 杂志文章


    authors: Cebrat M,Wieczorek Z,Siemion IZ

    更新日期:1996-01-01 00:00:00

  • A novel adipokinetic peptide in a water boatman (Heteroptera, Corixidae) and its bioanalogue in a saucer bug (Heteroptera, Naucoridae).

    abstract::The corpora cardiaca (CC) of two water bug species, the water boatman Corixa punctata and the saucer bug Ilyocoris cimicoides, contain a substance that cause hyperlipemia in the migratory locust. The primary sequence of one octapeptide belonging to the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH...


    pub_type: 杂志文章


    authors: Gäde G,Simek P,Marco HG

    更新日期:2007-03-01 00:00:00

  • Glucagon-like peptide-1 relaxes gastric antrum through nitric oxide in mice.

    abstract::Glucagon-like-peptide-1 (GLP-1) is a proglucagon-derived peptide expressed in the intestinal enteroendocrine-L cells and released after meal ingestion. GLP-1 reduces postprandial glycemia not only by its hormonal effects, but also by its inhibitory effects on gastrointestinal motility. Recently, we showed that GLP-1 a...


    pub_type: 杂志文章


    authors: Rotondo A,Amato A,Lentini L,Baldassano S,Mulè F

    更新日期:2011-01-01 00:00:00

  • House musk shrew (Suncus murinus, order: Insectivora) as a new model animal for motilin study.

    abstract::Although many studies have demonstrated the action of motilin on migrating motor complex by using human subjects and relatively large animals, the precise physiological mechanisms of motilin remain obscure. One reason for the lack of progress in this research field is that large animals are generally not suitable for ...


    pub_type: 杂志文章


    authors: Tsutsui C,Kajihara K,Yanaka T,Sakata I,Itoh Z,Oda S,Sakai T

    更新日期:2009-02-01 00:00:00

  • Increased levels of C-type natriuretic peptide in patients with idiopathic left ventricular dysfunction.

    abstract::C-type natriuretic peptide (CNP) is expressed in the vascular endothelium. It is not known whether CNP is specifically increased in patients with idiopathic left ventricular systolic dysfunction (ILVDys) with or without overt heart failure, and whether in these patients it is related with indicators of myocardial and/...


    pub_type: 杂志文章


    authors: Del Ry S,Giannessi D,Maltinti M,Prontera C,Iervasi A,Colotti C,Emdin M,L'Abbate A,Neglia D

    更新日期:2007-05-01 00:00:00

  • Urotensin-II activates L-arginine/nitric oxide pathway in isolated rat aortic adventitia.

    abstract::Urotensin-II (U-II), a cyclic peptide widely expressed in blood vessels, has diverse vascular actions that range from potent vasoconstriction to vasodilation. Although, U-II-induced vasodilation has been shown to be partially dependent on nitric oxide (NO), the involvement of vascular adventitia-derived NO, remains un...


    pub_type: 杂志文章


    authors: Lin L,Ding WH,Jiang W,Zhang YG,Qi YF,Yuan WJ,Tang CS

    更新日期:2004-11-01 00:00:00

  • The role of peptide YY in regulating glucose homeostasis.

    abstract::The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there ha...


    pub_type: 杂志文章,评审


    authors: Boey D,Sainsbury A,Herzog H

    更新日期:2007-02-01 00:00:00

  • Incorporation of regulatory peptide hormones by individual cells of the adrenal cortex: prolactin-adrenocorticotrophin differences.

    abstract::Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...


    pub_type: 杂志文章


    authors: Nolin JM

    更新日期:1980-10-01 00:00:00

  • RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin production.

    abstract::Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...


    pub_type: 杂志文章


    authors: Vieira-da-Motta O,Ribeiro PD,Dias da Silva W,Medina-Acosta E

    更新日期:2001-10-01 00:00:00

  • Participation of capsaicin-sensitive neurons in the cardiovascular effects of neurotensin in guinea pigs.

    abstract::Intravenous (IV) infusions of neurotensin (NT) in anesthetized guinea pigs elicited dose-dependent pressor effects and tachycardia. Both effects were significantly reduced or abolished in guinea pigs given a chronic treatment with the neurotoxin capsaicin. In guinea pig isolated atria NT evoked a positive inotropic an...


    pub_type: 杂志文章


    authors: Bachelard H,St-Pierre S,Rioux F

    更新日期:1987-11-01 00:00:00

  • Structural aspects of gastrin/CCK-like insect leucosulfakinins and FMRF-amide.

    abstract::The leucosulfakinins (LSKs), isolated from head extracts of the cockroach Leucophaea maderae, are sulfated neuropeptides with homology to gastrin and cholecystokinin. The undecapeptide LSK and decapeptide LSK-II stimulate contractions of the isolated cockroach hindgut. Several structural aspects of the two gastrin/CCK...


    pub_type: 杂志文章


    authors: Nachman RJ,Holman GM,Haddon WF

    更新日期:1988-01-01 00:00:00

  • Endothelin-1 induces bronchial myofibroblast differentiation.

    abstract::Endothelin-1 may contribute to bronchial smooth muscle constriction and airway remodelling in asthma, where bronchial epithelial cells represent an important source of this peptide. We report here that asthmatic bronchial epithelial cells exposed to allergens in vitro induce the differentiation of airway fibroblasts i...


    pub_type: 杂志文章


    authors: Sun G,Stacey MA,Bellini A,Marini M,Mattoli S

    更新日期:1997-01-01 00:00:00

  • Angiotensin II reduces serotonin release in the rat subfornical organ area.

    abstract::In the present study we used intracerebral microdialysis techniques to examine whether angiotensin II (ANG II) modulates the release of serotonin (5-hydroxytryptamine, 5-HT) in the subfornical organ (SFO) in freely moving rats. Extracellular concentrations of 5-HT and its metabolite 5-hydroxyindoleacetic acid (5-HIAA)...


    pub_type: 杂志文章


    authors: Tanaka J,Kariya K,Nomura M

    更新日期:2003-06-01 00:00:00

  • Alteration of NPY and Y1 receptor in dorsomedial and ventromedial areas of hypothalamus in anorectic tumor-bearing rats.

    abstract::Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...


    pub_type: 杂志文章


    authors: Chance WT,Xiao C,Dayal R,Sheriff S

    更新日期:2007-02-01 00:00:00

  • Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats.

    abstract::Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...


    pub_type: 杂志文章


    authors: Sato A,Yokoyama I,Ebina K

    更新日期:2015-11-01 00:00:00