Behavioral effects of the cyclic cholecystokinin peptide analogue JMV-320.

abstract：:The chronic hyperglycemia measured alongside diabetes development is associated with significant long-term damage and failure of various organs. In the present study it was shown that hyperglycemia induced early and long term increases in nitric oxide (NO) levels, kallikrein activity and vascular capillary permeabilit...

journal_title：Peptides

authors： Catanzaro O,Labal E,Andornino A,Capponi JA,Di Martino I,Sirois P

更新日期：2012-04-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...

journal_title：Peptides

authors： Sita LV,Diniz GB,Canteras NS,Xavier GF,Bittencourt JC

更新日期：2016-02-01 00:00:00

abstract：:Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP). CGRP, a very potent vasodilator, is the predominant ne...

journal_title：Peptides

authors： Deng PY,Li YJ

更新日期：2005-09-01 00:00:00

abstract：:The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and wat...

journal_title：Peptides

authors： Zetler G

更新日期：1985-01-01 00:00:00

abstract：:Skh-AMP1 (GRTSKQELCTWERGSVRQADKTIAG) is an antifungal peptide isolated from Satureja khuzistanica which has been shown to have strong antifungal activity against Aspergillus and Candida species, but no obvious hemolytic effects or cell cytotoxicity in vitro. In the present study, Skh-AMP1 was synthesized, and its mode...

journal_title：Peptides

authors： Khani S,Seyedjavadi SS,Hosseini HM,Goudarzi M,Valadbeigi S,Khatami S,Ajdary S,Eslamifar A,Amani J,Imani Fooladi AA,Razzaghi-Abyaneh M

更新日期：2020-01-01 00:00:00

abstract：:Somatostatin is reported in a new population of human sweat duct cells. The epithelial content of somatostatin-like immunoreactivity in normal human skin from various sites of the body was investigated using indirect immunofluorescence. With this methodology we found round-to-oval somatostatin-immunoreactive cells sit...

journal_title：Peptides

authors： Johansson O,Hilliges M,Wang L

更新日期：1993-03-01 00:00:00

abstract：:A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depressi...

journal_title：Peptides

authors： Han W,Wei Z,Dang R,Guo Y,Zhang H,Geng C,Wang C,Feng Q,Jiang P

更新日期：2020-09-01 00:00:00

abstract：:The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...

journal_title：Peptides

authors： Gilmore JP,Wesley CR,Huffman L,Nemeh MN

更新日期：1982-11-01 00:00:00

abstract：:Neuropeptide FF (NPFF) has been shown to act as an endogenous anti-analgesic peptide. In this paper, several peptide analogs of the selective ligand dNP(NMe)AFLFQPQRF-NH(2) modified in the putative address segment, were designed to be selective NPFF(2) receptor probes, synthesized and assayed. One peptide dA(NMe)AAFLF...

journal_title：Peptides

authors： Mazarguil H,Mollereau C,Czaplicki G,Zajac JM

更新日期：2012-09-01 00:00:00

abstract：:The ability of acute exercise to stimulate appetite and food intake depends on intensity, duration, and agouti-related protein (AGRP) levels. Fasting, as well as any negative energy balance, has been reported to increase AGRP expression in the arcuate nucleus (ARC) of the hypothalamus and other extra-hypothalamic tiss...

journal_title：Peptides

authors： Ghanbari-Niaki A,Nabatchian S,Hedayati M

更新日期：2007-05-01 00:00:00

abstract：:Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...

journal_title：Peptides

authors： Mata X,Renaud G,Mollereau C

更新日期：2019-12-01 00:00:00

abstract：:The presence and antimicrobial activity of antimicrobial peptides (AMPs) has been widely recognized as an evolutionary preserved part of the innate immune system. Based on evidence in animal models and humans, AMPs are now positioned as novel anti-infective agents. The current study aimed to evaluate the potential ant...

journal_title：Peptides

authors： Brouwer CP,Bogaards SJ,Wulferink M,Velders MP,Welling MM

更新日期：2006-11-01 00:00:00

abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...

journal_title：Peptides

authors： Chance WT,Xiao C,Dayal R,Sheriff S

更新日期：2007-02-01 00:00:00

abstract：:The effects of intracerebroventricular (ICV) and intravenous injections of bombesin (BBS) on food intake were investigated in turkeys. Adult turkey hens were injected ICV with 50 to 1000 ng of BBS. In addition, the effect of pretreatment with the BBS antagonist [d-Arg1, D-Phe5, D-Trp7,9, Leu11]-substance P was investi...

journal_title：Peptides

authors： Denbow DM

更新日期：1989-03-01 00:00:00

abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...

journal_title：Peptides

authors： Sample CJ,Hudak KE,Barefoot BE,Koci MD,Wanyonyi MS,Abraham S,Staats HF,Ramsburg EA

更新日期：2013-10-01 00:00:00

abstract：:Pea albumin 1F (PA1F), a plant peptide isolated from pea seeds, can dramatically increase blood glucose concentration by subcutaneous injection with a dosage of 5 or 10 microg/g (body weight) in normal and type II diabetic mice (KK/upj-Ay). The voltage-dependent anion channel 1 (VDAC-1) has been identified as the PA1F...

journal_title：Peptides

authors： Dun XP,Li FF,Wang JH,Chen ZW

更新日期：2008-06-01 00:00:00

abstract：:NPFF receptors are expressed in several brain regions directly or indirectly involved in cognition and behavior. However, the cognitive effects of the NPFF system have been poorly studied. Therefore, the aim of our study was to analyze the effects of i.c.v. injections of 1 DMe, a stable agonist of NPFF receptors, on b...

journal_title：Peptides

authors： Betourne A,Marty V,Ceccom J,Halley H,Lassalle JM,Zajac JM,Frances B,Mouledous L

更新日期：2010-02-01 00:00:00

abstract：:Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...

journal_title：Peptides

authors： Benter IF,Diz DI,Ferrario CM

更新日期：1993-07-01 00:00:00

abstract：:A putative genome duplication event within the Silurana lineage has given rise to the tetraploid Cameroon clawed frog Silurana epitropicalis (Fischberg, Colombelli, and Picard, 1982). Peptidomic analysis of norepinephrine-stimulated skin secretions of S. epitropicalis led to identification of 10 peptides with varying ...

journal_title：Peptides

authors： Conlon JM,Mechkarska M,Prajeep M,Sonnevend A,Coquet L,Leprince J,Jouenne T,Vaudry H,King JD

更新日期：2012-09-01 00:00:00

abstract：:Pretreatment with opioid antagonists enhances acquisition of Pavlovian fear conditioning. The present experiments attempted to characterize the type of opioid receptor responsible for this effect using a procedure that assessed the fear of rats to a chamber previously associated with electric shock (1 mA, 0.75 s). Fre...

journal_title：Peptides

authors： Fanselow MS,Kim JJ,Young SL,Calcagnetti DJ,DeCola JP,Helmstetter FJ,Landeira-Fernandez J

更新日期：1991-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...

journal_title：Peptides

authors： Park CW,Kim JH,Kim KM,Hwang JS,Kang SW,Kang HS,Cho BP,Yu CH,Kim HR,Lee BH

更新日期：2004-11-01 00:00:00

abstract：:In this study we investigated the role that dopaminergic pathways play in the miotic effect exerted by neurotensin after intracameral administration. Neurotensin was injected into the anterior chamber (AC) at a dose of 30 micrograms to 4 groups of albino rabbits which had previously undergone the following treatment: ...

journal_title：Peptides

authors： Tassorelli C,Spampinato D,Caruso P,Cavaliere S,Micieli G,Drago F,Nappi G

更新日期：1990-11-01 00:00:00

abstract：:Tight junctions (TJ) control paracellular permeability and apical-basolateral polarity of epithelial cells. Dysregulated permeability is associated with pathological conditions, such as celiac disease and inflammatory bowel disease. TJ formation is dependent on E-cadherin-mediated cell-cell adhesion and actin rearrang...

journal_title：Peptides

authors： Gopalakrishnan S,Tripathi A,Tamiz AP,Alkan SS,Pandey NB

更新日期：2012-05-01 00:00:00

abstract：:Dipeptidyl peptidase-4 (DPP-4) inhibitor and exercise have proven to be effective treatments for diabetes. However, the effects of these interventions in compensatory hyperinsulinemia prediabetic period are unknown. The purpose of this study was to determine if these interventions have protective effects on β-cell fun...

journal_title：Peptides

authors： Li Y,Xiao J,Tian H,Pei Y,Lu Y,Han X,Liu Y,Zhong W,Sun B,Fang F,Shu H

更新日期：2013-11-01 00:00:00

abstract：:The localization of CCK8-, bombesin- and VIP-like immunoreactivities in the myenteric plexus of the guinea pig small intestine has been studied by radioimmunoassay of extracts of longitudinal muscle strips obtained with and without adherent myenteric plexus; concentrations were compared with those in other regions of ...

journal_title：Peptides

authors： Hutchison JB,Dimaline R,Dockray GJ

更新日期：1981-04-01 00:00:00

abstract：:Two peptides, with a molecular mass of about 11 kDa and an N-terminal sequence abundant in arginine and glutamine residues, were isolated from wax gourd seeds. The isolation protocol included affinity chromatography on Affi-gel blue gel, ion-exchange chromatography on Mono-S and gel filtration on Superdex 75. The pept...

journal_title：Peptides

authors： Ng TB,Parkash A,Tso WW

更新日期：2003-01-01 00:00:00

abstract：:Apelin was recently found to be an inotropic polypeptide in isolated rat hearts, and intravenous injection of apelin can induce a transient decrease in blood pressure. To illustrate the mechanism of apelin-induced vasodilation, we observed the in vitro effects of apelin on the L-arginine (L-Arg)/nitric oxide (NO) path...

journal_title：Peptides

authors： Jia YX,Lu ZF,Zhang J,Pan CS,Yang JH,Zhao J,Yu F,Duan XH,Tang CS,Qi YF

更新日期：2007-10-01 00:00:00

abstract：:The distribution of the VIP containing structures was studied in the gut and in the paravertebral sympathetic ganglia of the quail and chick embryos by immunocytochemistry. In the gut, development of peptidergic nerves followed a craniocaudal gradient. Immunoreactive fibres were first visible in the oesophagus at day ...

journal_title：Peptides

authors： Fontaine-Perus J

更新日期：1984-03-01 00:00:00

abstract：:During a systemic search for peptides that possess the C-terminal amide structure, a novel heptapeptide with isoleucine amide was isolated from bovine serum by sequential steps of reversed phase HPLC. Microsequence and amino acid analyses revealed the structure: Asp-Thr-His-Lys-Ser-Glu-Ile-NH2. Since this peptide has ...

journal_title：Peptides

authors： Takamatsu K,Tatemoto K

更新日期：1991-03-01 00:00:00

abstract：:Intrathecal injection of mice with substance P (SP) or its C-terminal fragments results in a behavioral syndrome characterized by reciprocal caudally directed biting and scratching. Repeated injection of SP, but not SP C-terminal fragments, results in a decrease in the intensity of, or desensitization to, these SP-ind...

journal_title：Peptides

authors： Igwe OJ,Sun X,Larson AA

更新日期：1990-07-01 00:00:00