Abstract:
:Pea albumin 1F (PA1F), a plant peptide isolated from pea seeds, can dramatically increase blood glucose concentration by subcutaneous injection with a dosage of 5 or 10 microg/g (body weight) in normal and type II diabetic mice (KK/upj-Ay). The voltage-dependent anion channel 1 (VDAC-1) has been identified as the PA1F binding protein from mice pancreatic cell membrane, which may be involved in the regulation of enhancing blood glucose in response to PA1F binding. The results clearly show that peptide-signaling molecules from plants can affect mammalian physiological functions, especially, in association with glucose metabolism.
journal_name
Peptidesjournal_title
Peptidesauthors
Dun XP,Li FF,Wang JH,Chen ZWdoi
10.1016/j.peptides.2008.01.013subject
Has Abstractpub_date
2008-06-01 00:00:00pages
891-7issue
6eissn
0196-9781issn
1873-5169pii
S0196-9781(08)00042-9journal_volume
29pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::A novel antimicrobial peptide named odorranain-NR was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLSGILGAGKHIVCGLTGCAKA. Odorranain-NR was classified into a novel family of antimicrobial peptide although it shared sim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.01.004
更新日期:2008-04-01 00:00:00
abstract::The prothoracicotropic hormones (PTTH) are cerebral peptides that control insect postembryonic development by stimulating the prothoracic glands to synthesize ecdysteroids. Using immunoaffinity chromatography and SDS-PAGE, a 25.5 kDa big PTTH has been purified from Manduca sexta. Based upon SDS-PAGE and Western blot a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90142-4
更新日期:1993-05-01 00:00:00
abstract::Substance P (SP) has been implicated in the pathophysiology of ulcerative colitis (UC) and it has been suggested that blocking of its effect would be advantageous in this disease. Eosinophils have also been implicated in the pathophysiology of UC. In the present study, specimens from the sigmoid colon of UC patients w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.12.018
更新日期:2005-05-01 00:00:00
abstract::Although the biological effects of adrenomedullin (AM) and PAMP have been reported extensively in animal studies and from in-vitro experiments, relatively little information is available on responses to the hormone administered to man. This review summarizes data from the few studies carried out in man. In healthy vol...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00508-3
更新日期:2001-11-01 00:00:00
abstract::A myomodulin peptide has been suggested to mediate the response of the giant glial cells to stimulation of the Leydig interneuron in the central nervous system of the leech Hirudo medicinalis [Eur. J. Neurosci. 11 (1999) 3125]. We have now studied the glial response to the endogenous leech MM peptide (GMGALRL-NH(2), M...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00255-3
更新日期:2002-12-01 00:00:00
abstract::Neuropeptide S (NPS), the endogenous ligand of NPS receptor (NPSR), regulates many biological functions, including arousal, anxiety, locomotion and food intake. NPSR mRNA is expressed in several regions of central autonomic network through which the brain controls visceromotor and other responses essential for surviva...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.03.012
更新日期:2009-07-01 00:00:00
abstract::The gut-derived hormone peptide YY (PYY) is most commonly known for its effect on satiety, decreasing food intake and body weight in animals and humans. However, PYY is also involved in a wide range of digestive functions including regulating insulin secretion and glucose homeostasis. Over the last few years, there ha...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.07.031
更新日期:2007-02-01 00:00:00
abstract::The amidated beta-casomorphin morphiceptin Tyr-Pro-Phe-Pro-NH2 is an opioid peptide isolated from bovine milk beta-casein digests whose physiological significance remains unclear. Opiates are known to modify intestinal electrolyte transport by acting on receptors located on the serosal side of the intestine. The aim o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90074-0
更新日期:1989-01-01 00:00:00
abstract::We investigated the ability of sulfated cholecystokinin (26-33) (CCK-8) and cholecystokinin (30-33) (CCK-4) to induce taste aversion or avoidance conditioning (TAC) in a one-bottle testing paradigm after either intravenous (i.v.), intracerebroventricular (i.c.v.), or intraperitoneal (i.p.) administration. Significant ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00025-4
更新日期:1998-01-01 00:00:00
abstract::Binding studies have shown that [125I]NKA is a selective ligand of tachykinin septide-sensitive binding sites from membranes of the rat submaxillary gland. Indeed, this ligand bound with high affinity to a single population of sites. In addition, competition studies indicated that natural tachykinins and tachykinin-re...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00140-0
更新日期:1999-11-01 00:00:00
abstract::GIP receptor knockout mice were shown to be protected from the development of obesity on a high fat diet, suggesting a role of GIP in the development of obesity. In our study we aimed to test the hypothesis if excess of GIP could accelerate development of obesity and to identify GIP gene targets in adipose tissue. The...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.02.011
更新日期:2011-05-01 00:00:00
abstract::The presence of human melanin-concentrating hormone (MCH) was studied in the human brain by radioimmunoassay and immunocytochemistry. Immunoreactive MCH concentrations in the human brain ranged from 0.07 to 19.7 pmol/g wet weight. High performance liquid chromatography of the hypothalamus showed a large immunoreactive...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90158-d
更新日期:1993-05-01 00:00:00
abstract::Dendroaspis natriuretic peptide (DNP) is one of four members of the natriuretic peptide family sharing functional and structural properties. The purpose of the present study was to elucidate the physiological role of DNP on renal functions and its cellular mechanism in the rabbit kidney. DNP (5 μg/kg/min) infused intr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.12.006
更新日期:2012-01-01 00:00:00
abstract::Apelin was recently found to be an inotropic polypeptide in isolated rat hearts, and intravenous injection of apelin can induce a transient decrease in blood pressure. To illustrate the mechanism of apelin-induced vasodilation, we observed the in vitro effects of apelin on the L-arginine (L-Arg)/nitric oxide (NO) path...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.07.016
更新日期:2007-10-01 00:00:00
abstract::Injection of capsaicin into the hindpaw has been employed as a model of chemogenic nociception in mice. Intraplantar injection of nociceptin (30-240 pmol) produced a significant and dose-dependent antinociceptive activity in the capsaicin test. The nociceptin N-terminal fragments, (1-11) and (1-13), were also active w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.05.022
更新日期:2005-12-01 00:00:00
abstract::In an attempt to establish the role of F8Famide in opioid activity modulation, we examined the effects of intracerebroventricular administration of the F8Famide analogs (1DME)Y8Fa and (3D)Y8Fa on intestinal transit in mice. (1DME)Y8Fa (0.88 to 22 nmol) inhibited intestinal transit as did F8Famide and morphine. An IP i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90108-s
更新日期:1993-07-01 00:00:00
abstract::CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipens...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170309
更新日期:2020-06-01 00:00:00
abstract::In a previous study, we found that calcitonin gene-related peptide (CGRP) could be induced by proinflammatory factor IL-1beta in A549 human type II alveolar (AEII) epithelial cells. We investigated the mechanism of IL-1beta-induced CGRP secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved. In the p...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.03.021
更新日期:2007-06-01 00:00:00
abstract::In this study, an amphibian (Odorrana hejiangensis) skin extract was fractionated by reverse phase HPLC and fractions were screened for trypsin inhibitory activity. Using this initial approach, a novel trypsin inhibitory peptide was detected with an apparent protonated molecular mass of 1804.83 Da, as determined by MA...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.01.003
更新日期:2012-02-01 00:00:00
abstract::Scorpion venoms are rich sources of biologically active peptides that are classified into disulfide-bridged peptides (DBPs) and non-disulfide-bridged peptides (NDBPs). DBPs are the main scorpion venom components responsible for the neurotoxic effects observed during scorpion envenomation as they usually target membran...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2013.10.021
更新日期:2014-01-01 00:00:00
abstract::We investigated the plasma concentration of ghrelin peptide during pregnancy and lactation in rats. Plasma ghrelin levels on days 10 and 15 of pregnancy were significantly lower than those of the non-pregnant rats. Thereafter, the plasma ghrelin levels on day 20 of pregnancy sharply increased to levels comparable with...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.01.011
更新日期:2004-02-01 00:00:00
abstract::Obestatin regulates fluid and electrolyte homeostasis mainly by opposing the action of vasopressin (AVP). We measured plasma concentration of obestatin and AVP in patients with cardiorenal syndrome (CRS). Plasma AVP and obestatin concentration were measured in 34 patients with type II CRS. The data were compared to th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.08.022
更新日期:2012-12-01 00:00:00
abstract::The present study involves the isolation and characterization of secretin-like immunoreactivity from the brains of pigs, rats and dogs. Secretin-like immunoreactivity was extracted with 0.1 N HCl and subjected to SP-Sephadex ion exchange chromatography and gel filtration on a Sephadex G-50 superfine column. The averag...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90039-7
更新日期:1985-03-01 00:00:00
abstract::Self-administration of ethanol and food share many common features and Richter hypothesized that an increase in ethanol consumption would decrease feeding to balance the excess calories contained in the ethanol. Previously, we have shown that individual alcohol consumption correlates with neurotransmitter gene express...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.09.011
更新日期:2007-12-01 00:00:00
abstract::Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.03.003
更新日期:2018-05-01 00:00:00
abstract::Vestibular compensation is a process of CNS plasticity that is correlated to a return of resting activity in medial vestibular nucleus (MVN) neurons ipsilateral to a peripheral vestibular deafferentation. Systemic administration of melanocortin peptides accelerates the compensation process; the ACTH/MSH(4-9) analogue,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(96)00021-6
更新日期:1996-01-01 00:00:00
abstract::Are ACTH and insulin synthesized in tissues other than the pituitary and pancreas, respectively? ACTH and TSH are widely distributed in the rat brain but are restricted to the hypothalamic regions of the primate brain. It is concluded that these pituitary peptides are not synthesized in the brain in extrahypothalamic ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(81)90004-8
更新日期:1981-01-01 00:00:00
abstract::The biosynthetic activity of rat intermediate lobe melanotropes in vivo is inhibited by stimulation of dopamine D2 receptors. Individual melanotropes are innervated differentially by dopaminergic axons and vary in their levels of pro-opiomelanocortin (POMC) mRNA. We tested the hypothesis that placement of the lobe in ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00008-4
更新日期:1998-01-01 00:00:00
abstract::The role of the D-Trp residues in the sequence of the NK2-selective tachykinin antagonist, MEN 10207 (Asp-Tyr-D-Trp-Val-D-Trp-D-Trp-Arg-NH2). has been examined by replacement of each D-Trp with either the L-isomer or the residue naturally occurring in the same position of neurokinin A(4-10). The biological activity of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90053-r
更新日期:1991-09-01 00:00:00
abstract::Phylloseptins are antimicrobial peptides of 19-20 residues which are found in the skin secretions of the Phyllomedusa frogs that inhabit the tropical forests of South and Central Americas. The peptide sequences of PS-1, -2, and -3 carry an amidated C-terminus and they exhibit 74% sequence homology with major variation...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.06.022
更新日期:2008-10-01 00:00:00