Abstract:
:A large body of evidence suggests a relationship between depression and coronary heart disease (CHD). Angiotensin-Ⅱ (Ang-Ⅱ) and angiotensin-(1-7) [Ang-(1-7)] are considered to exert biological effects in both conditions. Here, we aimed to determine the role of Ang-Ⅱ and Ang-(1-7) in the occurrence of comorbid depression in patients with CHD. Our study included 214 CHD patients and 100 matched healthy controls. Serum Ang-Ⅱ and Ang-(1-7) levels were assessed by ELISA, and the depression symptoms were evaluated by the nine-item Patient Health Questionnaire (PHQ-9). Linear regression and correlation analyses were used to estimate the associations between PHQ-9 scores and Ang-Ⅱ and Ang-(1-7) serum levels. Six single-nucleotide polymorphisms (SNPs) spanning the angiotensin converting enzyme 2 (ACE2) and MAS1 genes were genotyped. The associations between SNPs and depression risk in CHD patients were examined using logistic regression analysis with adjustment for age and gender. Decreased Ang-(1-7) (P < 0.05) and an elevated Ang-Ⅱ/Ang-(1-7) ratio (P < 0.01) were observed in CHD patients with depression compared to CHD patients without depression. PHQ-9 scores were negatively correlated with Ang-(1-7) level (r=-0.44, P < 0.01) and positively correlated with the Ang-Ⅱ/Ang-(1-7) ratio (r = 0.33, P < 0.05). Furthermore, carriers of risk allele T for CHD with depression had significantly higher PHQ-9 scores (P < 0.05), lower Ang-(1-7) level (P < 0.01), and higher Ang-Ⅱ/Ang-(1-7) ratio (P < 0.05) than those CC carriers. Collectively, our results firstly showed that Ang-(1-7) serum level in CHD patients may protect against comorbid depression. Moreover, the imbalance between Ang-Ⅱ and Ang-(1-7) may contribute to depression in CHD patients.
journal_name
Peptidesjournal_title
Peptidesauthors
Han W,Wei Z,Dang R,Guo Y,Zhang H,Geng C,Wang C,Feng Q,Jiang Pdoi
10.1016/j.peptides.2020.170353subject
Has Abstractpub_date
2020-09-01 00:00:00pages
170353eissn
0196-9781issn
1873-5169pii
S0196-9781(20)30102-9journal_volume
131pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The presence of atrial natriuretic peptide (ANP) binding sites in the thymic cortex, medulla, and splenic white pulp suggests that this peptide may have immunoregulatory activity. We examined the effect of ANP on human natural killer (NK) cell activity. ANP significantly augmented NK cell cytotoxicity after twenty-fou...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90145-f
更新日期:1991-07-01 00:00:00
abstract::Angiotensin(1-7) had a compound effect on blood pressure of pithed Sprague-Dawley rats. The initial phase of the response consisted of an increase in MAP of short duration and independent of injected dose, followed by a decline of arterial pressure to values below baseline. Both the magnitude (range: -4 +/- 1 to -13 +...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90097-z
更新日期:1993-07-01 00:00:00
abstract::The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00122-9
更新日期:1999-01-01 00:00:00
abstract::Age-related changes in NPY-driven angiogenesis were investigated using Matrigel and aortic sprouting assays in young (2 months.) and aged (18 months.) mice. In both assays, NPY-induced vessel growth decreased significantly with age. In parallel, aged mice showed reduced expression (RT-PCR) of Y2 receptors and the NPY ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00581-2
更新日期:2002-01-01 00:00:00
abstract::We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90081-f
更新日期:1990-03-01 00:00:00
abstract::Several considerations led us to directly measure, using radioimmunoassay, the levels of dynorphin-A(1-8), cholecystokinin-8, and Met5-enkephalin-Arg6-Gly7-Leu8 (MERGL) in lysed-P2 membranes, membranes incubated 60 min at 25 degrees C in 50 mM TRIS-HCl at pH 7.4, and membranes preincubated 60 min at 25 degrees C in TR...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90039-8
更新日期:1987-07-01 00:00:00
abstract::Three neurotensin (NT) receptors have been cloned to date, two of which, NTS1 and NTS2, belong to the family of seven transmembrane domain receptors coupled to G proteins (GPCRs). NTS1 and NTS2 may activate multiple signal transduction pathways, involving several G proteins. However, whereas NT acts as an agonist towa...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.04.027
更新日期:2006-10-01 00:00:00
abstract::The immunoregulatory role of methionine-enkephalin (Met-enk) is well studied in mammals, but has not been explored in ectotherms despite the fact that this peptide is highly conserved in vertebrates. The present study demonstrates the diverse effects of Met-enk depending on its concentration and specific function of s...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2009.02.016
更新日期:2009-06-01 00:00:00
abstract::D-Amino acid substitutions in the anti-inflammatory/antipyretic Ac-alpha-MSH(11-13)-NH2 tripeptide of Ac-alpha-MSH(1-13)-NH2 were made and the altered peptides were injected in mice treated with picryl chloride. Ear swelling, measured 3 and 6 h after application of the irritant, was reduced by IP injections of Ac-alph...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90131-8
更新日期:1991-07-01 00:00:00
abstract::In non-pregnant goats, ovariectomy on day 12 of oestrous cycle resulted in parallel decrease of oxytocin and progesterone jugular concentration. Similarly, luteolysis, indicated by decreasing progesterone concentration, was accompanied by simultaneous release of oxytocin and oxytocin-associated neurophysins (mean of n...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90063-5
更新日期:1987-09-01 00:00:00
abstract::There is a well-documented association between cyclic changes to food intake and the changing ovarian hormone levels of the reproductive cycle in female mammals. Limited research on appetite-controlling gastrointestinal peptides has taken place in females, simply because regular reproductive changes in steroid hormone...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.02.010
更新日期:2017-04-01 00:00:00
abstract::Urocortin is a newly identified member of the CRF neuropeptide family. Urocortin has been found to bind with high affinity to CRF receptors. The present study investigated urocortin and CRF receptor expression in human colonic mucosa. Non-pathologic sections of adult colorectal tissues were obtained from patients with...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00335-1
更新日期:2000-12-01 00:00:00
abstract::LL-37 is the single cathelicidin host defense peptide in humans with direct antimicrobial and immunomodulatory activities. Specific regulation of LL-37 synthesis has emerged as a novel non-antibiotic approach to disease control and prevention. Short-chain fatty acids, and butyrate in particular, were found recently to...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.10.008
更新日期:2013-12-01 00:00:00
abstract::The melanocortin system plays an important role in energy homeostasis as well as skin pigmentation, steroidogenesis and exocrine gland function. In this study, we examined eight Ac-His-Phe-Arg-Trp-NH(2) tetrapeptides that were modified at the Phe position and pharmacologically characterized their activities at the hum...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.04.012
更新日期:2006-11-01 00:00:00
abstract::Three novel antimicrobial peptides designated ToAMP1, ToAMP2 and ToAMP3 were purified from Taraxacum officinale flowers. Their amino acid sequences were determined. The peptides are cationic and cysteine-rich and consist of 38, 44 and 42 amino acid residues for ToAMP1, ToAMP2 and ToAMP3, respectively. Importantly, acc...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.05.009
更新日期:2012-08-01 00:00:00
abstract::The relationship between gallbladder (GB) bile concentration and motility was studied in conscious dogs. The 12-h GB bile concentrations between meals could be divided into three periods: diluting, minimum, and concentrating periods. During the diluting period, inhibition of GB contractions by a CCKA receptor antagoni...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00247-1
更新日期:1997-01-01 00:00:00
abstract::Studies involving altered energy balance states in rodents have demonstrated that hypothalamic neuropeptide Y (NPY) activity is strongly activated in states of negative energy balance, such as periods of dietary restriction or starvation. However, in cancer cachexia, when there is a significant reduction in body weigh...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00183-7
更新日期:2000-01-01 00:00:00
abstract::VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90200-7
更新日期:1986-01-01 00:00:00
abstract::Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.032
更新日期:2013-03-01 00:00:00
abstract::We recently reported the direct inhibitory effect of adrenomedullin on caecal circular smooth muscle cells via cAMP system. This study was designed to determine whether the structurally related peptides to adrenomedullin (i.e.; calcitonin gene-related peptide (CGRP), calcitonin, and amylin) can inhibit the cholecystok...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00416-8
更新日期:2001-06-01 00:00:00
abstract::Pharmacological experiments suggest that satiation associated with intestinal infusion of several nutrients is mediated by CCK-A receptors. Otsuka Long-Evans Tokushima Fatty, (OLETF), rats do not express CCK-A receptors and are insensitive to the satiation-producing effects of exogenous CCK. To further evaluate the ro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00461-2
更新日期:2001-08-01 00:00:00
abstract::We tested the effects of intra-lateral septal infusions of neuropeptide Y (NPY) combined with systemic injections of topiramate in the DRL-72s paradigm and the elevated plus-maze test in male Wistar rats. Intra-lateral septal infusions of desipramine (5.0 microg/microl; P<0.05) or intra-lateral septal infusions of NPY...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.03.012
更新日期:2010-06-01 00:00:00
abstract::Many animal studies show an enhancing effect of vasopressin (VP) on memory, but not all human studies could confirm this finding. This study examined the influence of post-learning administration of VP (40 IU, intranasally) on the consolidation of declarative memories in healthy humans during different intervals of sl...
journal_title:Peptides
pub_type: 临床试验,杂志文章
doi:10.1016/s0196-9781(01)00625-8
更新日期:2002-03-01 00:00:00
abstract::Lysine-8-vasopressin (LVP) was injected into the lateral ventricle (ICV) or into the cisterna magna (c.m.) of ether-anesthetized rats. ICV injection of LVP decreased the blood pressure (BP), whereas c.m. administration increased it. The opposite effects of ICV versus c.m. administration of the peptide might be related...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90021-5
更新日期:1986-05-01 00:00:00
abstract::We found that neurokinin A (NKA) and neurokinin B (NKB) induce an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) in murine neuroblastoma C1300 cells (EC50: NKA 87 +/- 13 nM, NKB 97 +/- 15 nM). Substance P (SP) also caused a transient Ca2+ increase, although the potency of SP was much less than that...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00166-9
更新日期:1995-01-01 00:00:00
abstract::An outbreak caused by 2019 novel coronavirus (2019-nCoV) was first identified in Wuhan City, Hubei Province, China. The new virus was later named SARS-CoV-2. The virus has affected tens of thousands of patients in the world. The infection of SARS-CoV-2 causes severe pneumonia and even death. It is urgently needed to f...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170328
更新日期:2020-08-01 00:00:00
abstract::In addition to wasp kinins, the wasp venom contains a series of hydrophobic peptides, mastoparans and chemotactic peptides as major peptidergic components. The first major component in the venom is mastoparam. The peptides in the mastoparan family are tetradecapeptide amides which cause degranulation of the mast cells...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90409-7
更新日期:1985-01-01 00:00:00
abstract::Recent studies have provided evidence for the dense localization of atrial natriuretic factor (ANF) in the anteroventral third ventricle (AV3V) region of the rat brain. This area is currently thought to be involved in the regulation of blood pressure and fluid and electrolyte balance. To investigate whether ANF may pl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90425-5
更新日期:1985-11-01 00:00:00
abstract::Antibiotic therapy for methicillin-resistant Staphylococcus aureus (MRSA) infections is becoming more difficult in hospitals and communities because of strong biofilm-forming properties and multidrug resistance. Biofilm-associated MRSA is not affected by therapeutically achievable concentrations of antibiotics. Theref...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.08.008
更新日期:2013-11-01 00:00:00
abstract::Rhoptries are specialized secretory organelles found in all members of the genus Plasmodium whose proteins have been considered as promising vaccine candidates due to their involvement in cell invasion and the formation of the parasitophorous vacuole (PV). The Plasmodium falciparum Pf34 protein was recently identified...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.07.009
更新日期:2010-11-01 00:00:00