Abstract：
:Three novel antimicrobial peptides designated ToAMP1, ToAMP2 and ToAMP3 were purified from Taraxacum officinale flowers. Their amino acid sequences were determined. The peptides are cationic and cysteine-rich and consist of 38, 44 and 42 amino acid residues for ToAMP1, ToAMP2 and ToAMP3, respectively. Importantly, according to cysteine motifs, the peptides are representatives of two novel previously unknown families of plant antimicrobial peptides. ToAMP1 and ToAMP2 share high sequence identity and belong to 6-Cys-containing antimicrobial peptides, while ToAMP3 is a member of a distinct 8-Cys family. The peptides were shown to display high antimicrobial activity both against fungal and bacterial pathogens, and therefore represent new promising molecules for biotechnological and medicinal applications.
journal_name
Peptidesjournal_title
Peptidesauthors
Astafieva AA,Rogozhin EA,Odintsova TI,Khadeeva NV,Grishin EV,Egorov TsAdoi
10.1016/j.peptides.2012.05.009subject
Has Abstractpub_date
2012-08-01 00:00:00pages
266-71issue
2eissn
0196-9781issn
1873-5169pii
S0196-9781(12)00230-6journal_volume
36pub_type
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