Abstract:
:Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gastrointestinal transit were investigated. The results indicated that intracerebroventricular (i.c.v.) administration of neuronostatin (1, 5, 10 or 20nmol/mouse) delayed gastric emptying and gastrointestinal transit in a dose-related manner in mice. The effects were significantly reversed by melanocortin 3/4 receptor antagonist SHU9119 or classical opioid receptor antagonist naloxone, suggesting that the central melanocortin system and opioid system may be involved in the gastrointestinal effects elicited by i.c.v. administration of neuronostatin. In addition, we found that C-terminal amidation modification of neuronostatin is essential to exert its gastrointestinal effects. These results indicated that neuronostatin may play an important role in regulating gastrointestinal function.
journal_name
Peptidesjournal_title
Peptidesauthors
Su SF,Yang AM,Yang SB,Wang NB,Lu SS,Wang HH,Chen Qdoi
10.1016/j.peptides.2012.03.013subject
Has Abstractpub_date
2012-05-01 00:00:00pages
31-5issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(12)00131-3journal_volume
35pub_type
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