The trefoil peptides spasmolytic polypeptide and intestinal trefoil factor are major secretory products of the rat gut.

abstract：:In the present study, the C-terminus of endomorphin (Tyr(1)-Pro(2)-Trp/Phe(3)-Phe(4)-NH(2), EMs) analogs [Xaa(4)-R]EMs, modified by substitution of a non-aromatic residue for Phe(4) and ending up with -NH-benzyl, were designed to generate an atypical conformationally constrained peptide set. We investigated the effect...

journal_title：Peptides

authors： Yu Y,Shao X,Wang CL,Liu HM,Cui Y,Fan YZ,Liu J,Wang R

更新日期：2007-04-01 00:00:00

abstract：:The effects of third ventricular (IVT) injection of 25 micrograms of bradykinin (BK) upon plasma levels of LH, FSH, TSH, GH and prolactin were investigated in conscious ovariectomized female rats bearing indwelling jugular cannulae. Some animals were pretreated with bradykinin potentiating factor (BPF). Intravenous ad...

journal_title：Peptides

authors： Steele MK,Negro-Vilar A,McCann SM

更新日期：1980-10-01 00:00:00

abstract：:Gastrin/CCK peptides in extracts from bovine and porcine pituitary have been characterized by Sephadex gel filtration, reverse phase liquid chromatography and a CCK radioimmunoassay (RIA) which detects both CCK and gastrin [4]. Porcine pituitary extracts contain a small amount of two peptides with chromatographic beha...

journal_title：Peptides

authors： Beinfeld MC

更新日期：1982-05-01 00:00:00

abstract：:The oligopeptide transporter (PepT1) is located on the brush-border membrane of the intestinal epithelium which has been regarded as a mediator of protein absorption. Here, we cloned and characterized PepT1 genes from diploid (red crucian carp), triploid and tetraploid fish. Then, the PepT1 expression pattern in diffe...

journal_title：Peptides

authors： Liu Z,Zhou Y,Liu S,Zhao Q,Feng J,Lu S,Xiong G,Xie D,Zhang J,Liu Y

更新日期：2014-02-01 00:00:00

abstract：:It is known that painful tissue injury evokes an increase in dynorphin in spinal neurons. It is not known, however, whether dynorphinergic systems respond similarly to the pain that accompanies peripheral neuropathy. Radioimmunoassays and immunocytochemistry were used to evaluate changes in dynorphin A(1-8) in the spi...

journal_title：Peptides

authors： Kajander KC,Sahara Y,Iadarola MJ,Bennett GJ

更新日期：1990-07-01 00:00:00

abstract：:Given the importance of G-protein coupled receptors in the regulation of many physiological functions, deciphering the relationships between genotype and phenotype in past and present hominin GPCRs is of main interest to understand the evolutionary process that contributed to the present-day variability in human trait...

journal_title：Peptides

authors： Mata X,Renaud G,Mollereau C

更新日期：2019-12-01 00:00:00

abstract：:Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...

journal_title：Peptides

authors： Peigneur S,Van Der Haegen A,Möller C,Waelkens E,Diego-García E,Marí F,Naudé R,Tytgat J

更新日期：2013-03-01 00:00:00

abstract：:The temporins are a family of hydrophobic, C-terminally alpha-amidated antimicrobial peptides that are synthesized in the skins of a wide range of species of frogs belonging to the genus Rana. In the present study, we investigated using RT-PCR the expression of preprotemporin mRNAs in extradermal tissues of Tago's bro...

journal_title：Peptides

authors： Iwamuro S,Nakamura M,Ohnuma A,Conlon JM

更新日期：2006-09-01 00:00:00

abstract：:To identify male-specific genes that could be involved in male development, we screened a subtracted male reproductive tract library and isolated a novel gene named Mar-Mrr (M. rosenbergii male reproduction-related gene). The Mar-Mrr cDNA sequence consists of 683 nucleotides with a 333 nucleotide open reading frame, e...

journal_title：Peptides

authors： Cao JX,Yin GL,Yang WJ

更新日期：2006-04-01 00:00:00

abstract：:Many animal studies show an enhancing effect of vasopressin (VP) on memory, but not all human studies could confirm this finding. This study examined the influence of post-learning administration of VP (40 IU, intranasally) on the consolidation of declarative memories in healthy humans during different intervals of sl...

journal_title：Peptides

authors： Gais S,Sommer M,Fischer S,Perras B,Born J

更新日期：2002-03-01 00:00:00

abstract：:High performance-gel permeation chromatography (HP-GPC) evaluation of human plasma and serum incubated at 37 degrees C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p < 0.001). Vessel dilator'...

journal_title：Peptides

authors： Overton RM,Vesely DL

更新日期：1996-01-01 00:00:00

abstract：:Nonmammalian peptides of the tachykinin, bombesin and opioid families, injected into the brain ventricles, potently and specifically affect drinking behaviour of rats and pigeons. These peptides, or at least their counterparts, have been found in the brain of mammals and birds. It has been hypothesized that these endo...

journal_title：Peptides

authors： de Caro G,Massi M

更新日期：1985-01-01 00:00:00

abstract：:Dermorphins are potent opiate-like peptides isolated from the skin of some species of frogs. They are characterized by the presence of a D-amino acid residue, which is crucial for bioactivity. A number of analogues were prepared in order to evaluate the structure-activity relationships. The syntheses were accomplished...

journal_title：Peptides

authors： de Castiglione R,Faoro F,Perseo G,Piani S,Santangelo F,Melchiorri P,Falconieri Erspamer G,Erspamer V,Guglietta A

更新日期：1981-10-01 00:00:00

abstract：:Peptides have the potential to be potent pharmaceutical agents for the treatment of many central nervous system derived maladies. Unfortunately peptides are generally water-soluble compounds that will not enter the central nervous system, via passive diffusion, due to the existence of the blood-brain barrier. Peptides...

journal_title：Peptides

authors： Witt KA,Gillespie TJ,Huber JD,Egleton RD,Davis TP

更新日期：2001-12-01 00:00:00

abstract：:Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...

journal_title：Peptides

authors： Hegbrant J,Thysell H,Ekman R

更新日期：1995-01-01 00:00:00

abstract：:The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantif...

journal_title：Peptides

authors： Correa FM,Viswanathan M,Ciuffo GM,Tsutsumi K,Saavedra JM

更新日期：1995-01-01 00:00:00

abstract：:The effects of adrenomedullin (ADM) on C6 glioma cells were investigated. [125I]ADM bound with high affinity (Kd = 24 nM) to a single class of sites (Bmax = 36,000/cell) in C6 cells. Specific [125I]ADM binding was inhibited with high affinity by ADM (IC50 value of 10 nM) but not ADM(22-52) or pro-adrenomedullin N-term...

journal_title：Peptides

authors： Moody TW,Miller MJ,Mártinez A,Unsworth E,Cuttitta F

更新日期：1997-01-01 00:00:00

abstract：:As part of a continuing search for potential anticancer drug candidates from antimicrobial peptides of marine organisms, tilapia (Oreochromis mossambicus) hepcidin TH2-3 was evaluated in several tumor cell lines. The results indicated that TH2-3, a synthetic 20-mer antimicrobial peptide, specifically inhibited human f...

journal_title：Peptides

authors： Chen JY,Lin WJ,Lin TL

更新日期：2009-09-01 00:00:00

abstract：:A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...

journal_title：Peptides

authors： Livesey JH,Carne A,Irvine CH,Ellis J,Evans MJ,Smith R,Donald RA

更新日期：1991-11-01 00:00:00

abstract：:The chronic hyperglycemia measured alongside diabetes development is associated with significant long-term damage and failure of various organs. In the present study it was shown that hyperglycemia induced early and long term increases in nitric oxide (NO) levels, kallikrein activity and vascular capillary permeabilit...

journal_title：Peptides

authors： Catanzaro O,Labal E,Andornino A,Capponi JA,Di Martino I,Sirois P

更新日期：2012-04-01 00:00:00

abstract：:Cholecystokinin induces a reduction in exploratory behaviors which could reflect an underlying behavioral state of either satiety or malaise. To investigate these alternative hypotheses, the effects of CCK were compared to the effects of (a) consumption of an extra quantity of palatable food, of (b) bombesin at doses ...

journal_title：Peptides

authors： Crawley JN

更新日期：1983-07-01 00:00:00

abstract：:Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...

journal_title：Peptides

authors： Dong S,Li CL,Liang WD,Chen MH,Bi YT,Li XW

更新日期：2014-09-01 00:00:00

abstract：:The anorectic effect of IP injection of amylin (1 microgram/kg) was abolished by simultaneous IP injection of the amylin receptor antagonist calcitonin gene-related peptide-(8-37) [CGRP(8-37), 10 micrograms/kg]. The IP injection of pancreatic glucagon (400 micrograms/kg) at dark onset also reduced food intake in 24-h ...

journal_title：Peptides

authors： Lutz TA,Del Prete E,Szabady MM,Scharrer E

更新日期：1996-01-01 00:00:00

abstract：:As we commemorate the 25th anniversary of the journal Peptides, it is timely to review the functional significance of the bombesin (BB)-like peptides and receptors in the CNS. Over two decades ago we published an article in the journal Peptides demonstrating that BB-like peptides are present in high densities in certa...

journal_title：Peptides

authors： Moody TW,Merali Z

更新日期：2004-03-01 00:00:00

abstract：:Deltorphin, a heptapeptide that selectively binds to delta receptors, was intracerebroventricularly administered to mice belonging to the strains C57BL/6 and DBA/2 immediately after training in a one-trial inhibitory avoidance task. The retention performance of both strains was improved by the peptide administration, ...

journal_title：Peptides

authors： Pavone F,Populin R,Castellano C,Kreil G,Melchiorri P

更新日期：1990-05-01 00:00:00

abstract：:Salusins originally identified using bioinformatics analyses have been shown to act on the cardiovascular and endocrine systems. Although the hypotensive activity of salusin-alpha is limited, it exerts a significant anti-atherosclerotic effect via suppression of foam cell formation in human monocyte-derived macrophage...

journal_title：Peptides

authors： Sato K,Koyama T,Shichiri M

更新日期：2008-12-01 00:00:00

abstract：:To study the effects of inducing stereo-chemical modifications in the structure of dermorphin (DM) so as to improve its mu-opioid receptor affinity and its resistance to C-terminal enzymatic degradation, in the Institute of Molecular Genetics of Moscow, we synthesized a new DM analogue ([DPro(6)]DM) and analyzed the c...

journal_title：Peptides

authors： Broccardo M,Usenko AB,Uranova MG,Guzevatykh LS,Kamensky AA,Andreeva LA,Alfeeva LY,Myasoedov NF,Giannini E,Improta G,Emel'yanova TG

更新日期：2003-03-01 00:00:00

abstract：:Generally, biomacromolecules, such as DNA, RNA, and proteins, cannot freely permeate into cells from outside the membrane. Protein transduction domains (PTDs) are peptides containing a large number of basic amino acids that can deliver macromolecules into living cells. Arginine-rich intracellular delivery (AID) peptid...

journal_title：Peptides

authors： Hu JW,Liu BR,Wu CY,Lu SW,Lee HJ

更新日期：2009-09-01 00:00:00

abstract：:We investigated the plasma concentration of ghrelin peptide during pregnancy and lactation in rats. Plasma ghrelin levels on days 10 and 15 of pregnancy were significantly lower than those of the non-pregnant rats. Thereafter, the plasma ghrelin levels on day 20 of pregnancy sharply increased to levels comparable with...

journal_title：Peptides

authors： Shibata K,Hosoda H,Kojima M,Kangawa K,Makino Y,Makino I,Kawarabayashi T,Futagami K,Gomita Y

更新日期：2004-02-01 00:00:00

abstract：:Pretreatment with opioid antagonists enhances acquisition of Pavlovian fear conditioning. The present experiments attempted to characterize the type of opioid receptor responsible for this effect using a procedure that assessed the fear of rats to a chamber previously associated with electric shock (1 mA, 0.75 s). Fre...

journal_title：Peptides

authors： Fanselow MS,Kim JJ,Young SL,Calcagnetti DJ,DeCola JP,Helmstetter FJ,Landeira-Fernandez J

更新日期：1991-09-01 00:00:00