Abstract:
:High performance-gel permeation chromatography (HP-GPC) evaluation of human plasma and serum incubated at 37 degrees C up to 24 h after the addition of long-acting natriuretic peptide (LANP) revealed a 25% decrease in LANP's peak at 2 h followed by an increase in plasma without EDTA at 8 h (p < 0.001). Vessel dilator's HP-GPC peak did not decrease until after 8 h of incubation. These findings help explain the prolonged half-lives and 6-24 higher plasma concentrations of vessel dilator and LANP compared to atrial natriuretic factor and kaliuretic peptide, which are completely degraded in plasma within 2 h.
journal_name
Peptidesjournal_title
Peptidesauthors
Overton RM,Vesely DLdoi
10.1016/s0196-9781(96)00185-4subject
Has Abstractpub_date
1996-01-01 00:00:00pages
1155-62issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(96)00185-4journal_volume
17pub_type
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