Abstract:
:Rhoptries are specialized secretory organelles found in all members of the genus Plasmodium whose proteins have been considered as promising vaccine candidates due to their involvement in cell invasion and the formation of the parasitophorous vacuole (PV). The Plasmodium falciparum Pf34 protein was recently identified as a rhoptry-neck protein located in detergent-resistant microdomains (DRMs) that is expressed in mature intraerythrocytic parasite stages, but its biological function is still unknown. Receptor-ligand assays carried out in this study found that peptides 36,051 ((101)DKKFSESLKAHMDHLKILNN(120)Y), 36,053 ((141)KKYIIKEIQNNKYLNKEKKS(160)), 36,055 ((181)WLESVNNIEEKSNILKNIKS(200)Y) and 36,056 ((201)QLLNNIASLNHTLSEEIKNI(220)Y), located in the central portion of Pf34, were found to establish protease-sensitive interactions of high affinity and specificity with receptors on the surface of red blood cell (RBCs). In vitro assays showed that Pf34 high activity binding peptides (HABPs) inhibit invasion of RBCs by P. falciparum merozoites, therefore suggesting that Pf34 could act as an adhesin during invasion and supporting the inclusion of Pf34 HABPs in further studies to develop antimalarial control methods.
journal_name
Peptidesjournal_title
Peptidesauthors
Arévalo-Pinzón G,Curtidor H,Vanegas M,Vizcaíno C,Patarroyo MA,Patarroyo MEdoi
10.1016/j.peptides.2010.07.009subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1987-94issue
11eissn
0196-9781issn
1873-5169pii
S0196-9781(10)00304-9journal_volume
31pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Mate attraction in Aplysia involves the long-distance water-borne protein pheromones attractin, enticin, and temptin which are released during egg-laying. Other water-borne pheromones are predicted to act in concert with attractin, enticin, and temptin, but their identities were unknown. We recently identified a highl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.10.024
更新日期:2005-03-01 00:00:00
abstract::Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion. The development of brown-like adipocytes in WAT is controlled by hypothalamic NPY neurons through interacti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.10.018
更新日期:2015-01-01 00:00:00
abstract::The typical cardiovascular response to polymicrobial sepsis is characterized by an early, hyperdynamic phase followed by a late, hypodynamic phase. Although the factors and/or mediators responsible for producing the transition from the hyperdynamic to the hypodynamic stage are not fully understood, recent studies have...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00534-4
更新日期:2001-11-01 00:00:00
abstract::We investigated the plasma concentration of ghrelin peptide during pregnancy and lactation in rats. Plasma ghrelin levels on days 10 and 15 of pregnancy were significantly lower than those of the non-pregnant rats. Thereafter, the plasma ghrelin levels on day 20 of pregnancy sharply increased to levels comparable with...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.01.011
更新日期:2004-02-01 00:00:00
abstract::Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00497-1
更新日期:2001-10-01 00:00:00
abstract::Short cell penetrating peptides (CPP) are widely used in vitro to transduce agents into cells. But their systemic effect has not been yet studied in detail. We studied the systemic effect of the cell penetrating peptides, penetratin, transportan and pro-rich, on rat hemodynamic functions. Intra-arterial monitoring of ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.09.017
更新日期:2011-12-01 00:00:00
abstract::We applied computational biology to identify the linear amino acid sequence recognized by a mouse monoclonal antibody raised against the full length HPV16 E7 oncoprotein. Computer-assisted search for the epitopic peptide used two parameters: the capability of E7 peptides to bind to MHC class II molecules, and the simi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00539-3
更新日期:2001-12-01 00:00:00
abstract::VIP and related fragments were prepared by the solid-phase method. The peptides were assembled on a benzhydrylamine resin and couplings of the Boc-amino acids were carried out by the symmetrical anhydride method. Cleavage was achieved by treatment with liquid HF and purification was accomplished by successive steps of...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90202-x
更新日期:1984-03-01 00:00:00
abstract::Kiss1 mRNA and its corresponding peptide products, kisspeptins, are expressed in two restricted brain areas of rodents, the anteroventral periventricular nucleus (AVPV) and the arcuate nucleus (ARC). The concentration of mature kisspeptins may not directly correlate with Kiss1 mRNA levels, because mRNA translation and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.04.013
更新日期:2013-07-01 00:00:00
abstract::Neurotensin and somatostatin have both been shown to inhibit gastric acid secretion, but no interaction between these peptides has been demonstrated. To determine whether somatostatin might be a mediator of neurotensin's effect on pentagastrin-stimulated gastric acid secretion, we performed the following three experim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90025-x
更新日期:1992-11-01 00:00:00
abstract::Neural membrane fractions, prepared from brain-subesophageal ganglion complexes of the adult lepidopteran Lymantria dispar, contain at least two peptidases capable of metabolizing locust adipokinetic hormone-I in vitro. The initial fragments, pGlu1-Leu2-Asn3 and Phe4-Thr5-Pro6-Asn7-Trp8-Gly9-Thr10, result from the act...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02098-5
更新日期:1996-01-01 00:00:00
abstract::The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cel...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.024
更新日期:2012-12-01 00:00:00
abstract::TRH and PS-24 (a TRH peptidase resistant analogue) induce different effects on body temperature and motor activity in rats kept at 4 degrees C. PS-24 induced hypothermia, but TRH did not. PS-24 induced hypermotility, while TRH induced slight hypomotility. The thermal effect of TRH in hypophysectomized rats was similar...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(81)80024-1
更新日期:1981-07-01 00:00:00
abstract::Neuropeptide Y-containing nerve fibers have previously been demonstrated to innervate the mammalian ovary. These nerve fibers innervate primarily the vasculature. In this study we have developed a method for in vivo measurement of the ovary blood flow rate by means of the 133Xe method. Using this technique we measured...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90041-3
更新日期:1990-05-01 00:00:00
abstract::In these studies the pattern of feeding behavior during continuous intraventricular (IVT) infusion of NPY for 4 hr in the satiated female rat was monitored. Whereas saline infusion was ineffective, each of the three doses of NPY (117, 470 or 1175 pmol/hr) increased feeding during the entire 4 hr infusion and 2 hr post...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90112-x
更新日期:1988-07-01 00:00:00
abstract::Phoenixin, a recently discovered 20-amino acid peptide was implicated in reproduction. However, the expression in food intake-regulatory nuclei such as the paraventricular nucleus, the arcuate nucleus and the nucleus of the solitary tract suggests an implication of phoenixin in food intake regulation. Therefore, we in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.08.004
更新日期:2017-10-01 00:00:00
abstract::Antibodies directed against amyloid beta protein (AssP) have been suggested to be effective in the treatment of Alzheimer's disease (AD). Here, we used in vivo and in vitro models to test some of the mechanisms by which antibodies may produce their effects. We found that the blood-to-brain uptake of murine AssP1-42 wa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.09.016
更新日期:2005-02-01 00:00:00
abstract::A novel antimicrobial peptide named odorranain-NR was identified from skin secretions of the diskless odorous frog, Odorrana grahami. It is composed of 23 amino acids with an amino acid sequence of GLLSGILGAGKHIVCGLTGCAKA. Odorranain-NR was classified into a novel family of antimicrobial peptide although it shared sim...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.01.004
更新日期:2008-04-01 00:00:00
abstract::Interleukin-1 beta (IL-1β) significantly influences cognitive processes. Treatments which raise the level of IL-1β in the brain impair memory consolidation in contextual fear conditioning. However, the effect of IL-1β on memory reconsolidation has not yet been established. The melanocortin α-melanocyte-stimulating hor...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.07.018
更新日期:2010-11-01 00:00:00
abstract::The rat central and peripheral nervous system contains a widespread distribution of BPP-like immunoreactive neurons. Some of these neurons coexist with a catecholamine, probably mostly NE. This peptide appears to be releaseable by nerve stimulation. Catecholamine releasing agents such as reserpine do not appear to dep...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90128-0
更新日期:1982-05-01 00:00:00
abstract::The decapeptide from the frog Hyla caerulea, caerulein (caerulein diethylammonium hydrate, ceruletide, CER) is chemically closely related to the C-terminal octapeptide of cholecystokinin (CCK-8). Like CCK-8, CER and some of its analogues produce many behavioural effects in mammals: inhibition of intake of food and wat...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(85)90348-1
更新日期:1985-01-01 00:00:00
abstract::Effects of pentobarbital, chlordiazepoxide and ethanol were studied alone and in combination with thyrotropin-releasing hormone (TRH), IM, on punished behavior. Key-peck responses of pigeons were maintained by food presentation under a fixed-interval 3-min schedule in which every 30th response produced shock. Moderate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90026-3
更新日期:1984-07-01 00:00:00
abstract::This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Syst...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.02.019
更新日期:2013-06-01 00:00:00
abstract::Diapause pupae of the swallowtail butterfly Papilio xuthus L. exhibit diapause-green, orange and brownish-orange color polymorphism. Development of orange pupae involves a neuroendocrine factor inducing orange pupa (Orange-Pupa-Inducing Factor, OPIF), which is secreted from the head-thoracic region during late pharate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.06.025
更新日期:2006-03-01 00:00:00
abstract::Jingzhaotoxin-II (JZTX-II) is a 32-residue peptide from the Chinese tarantula Chilobrachys jingzhao venom, and preferentially inhibits the fast inactivation of the voltage-gated sodium channels (VGSCs) in rat cardiac myocytes. In the present study, we elucidated the action mechanism of JZTX-II inhibiting hNav1.5, a VG...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.03.012
更新日期:2015-06-01 00:00:00
abstract::We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decre...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.02.003
更新日期:2005-07-01 00:00:00
abstract::Growing evidence suggests that the neuropeptide Y (NPY) system plays an important role in the immune system. Yet, little is known about the expression of NPY and receptors in the immune system. Moreover, original contradicting results have confused the picture and hampered a clear understanding of its role in the immu...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2006.09.030
更新日期:2007-02-01 00:00:00
abstract::Calcitonin gene-related peptide (CGRP) immunoreactive material has been found in extracts of the intestine, however, the structure of intestinal CGRP is not known. Analytical reverse phase HPLC and ion-exchange FPLC revealed one predominant immunoreactive CGRP peak in rabbit intestinal extracts. This material was puri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90014-g
更新日期:1991-03-01 00:00:00
abstract::Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90008-x
更新日期:1980-01-01 00:00:00
abstract::On attempts to identify toxins showing original profile of activity among K+ channels, we purified Kbot1, a scorpion toxin that blocks Kv1 and SK potassium channels. With 28 amino-acid residues, Kbot1 is the shortest toxin sequenced in Buthus occitanus scorpion. It is linked by three disulfide bridges and its primary ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.02.017
更新日期:2004-04-01 00:00:00