Abstract:
:We sought to establish Endothelin (ET-3) role in the central regulation of bile secretion in the rat. The intracerebroventricular (icv) injection of ET-3 evoked a cholestatic or a choleretic effect depending on the administered dose. Lower doses increased bile flow and bicarbonate excretion, whereas higher doses decreased bile flow and bile acid output. ET-3 effects were dependent on brain nitric oxide and independent of the autonomic nervous system or hemodynamic variations. A selective ETB antagonist abolished the cholestatic effect, whereas the choleretic effect was totally inhibited by either ETA or ETB selective blockade. These results show that ET-3 applied to the brain modified through a nitric oxide pathway distinct bile flow fractions depending on the administered dose and give further insights into the complexity of brain-liver interaction.
journal_name
Peptidesjournal_title
Peptidesauthors
Rodríguez MR,Sabbatini ME,Santella G,Dabas P,Villagra A,Vatta MS,Bianciotti LGdoi
10.1016/j.peptides.2005.02.003subject
Has Abstractpub_date
2005-07-01 00:00:00pages
1219-27issue
7eissn
0196-9781issn
1873-5169pii
S0196-9781(05)00039-2journal_volume
26pub_type
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