Neuropeptide Y reduces ovarian blood flow in the rabbit.

abstract：:Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...

journal_title：Peptides

authors： Neyama H,Hamada Y,Tsukahara R,Narita M,Tsukamoto K,Ueda H

更新日期：2018-09-01 00:00:00

abstract：:We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...

journal_title：Peptides

authors： Zhao Y,Wang MY,Hao K,Chen XQ,Du JZ

更新日期：2013-06-01 00:00:00

abstract：:D-Amino acid substitutions in the anti-inflammatory/antipyretic Ac-alpha-MSH(11-13)-NH2 tripeptide of Ac-alpha-MSH(1-13)-NH2 were made and the altered peptides were injected in mice treated with picryl chloride. Ear swelling, measured 3 and 6 h after application of the irritant, was reduced by IP injections of Ac-alph...

journal_title：Peptides

authors： Hiltz ME,Catania A,Lipton JM

更新日期：1991-07-01 00:00:00

abstract：:To determine the functional role for and the pharmacological specificity of developing gastrointestinal CCK receptors, in vitro pyloric contractility and autoradiographic CCK receptor binding were examined in pups aged 1-20 days. CCK contracted the gastroduodenal junction at all ages, while nonsulfated CCK-8 (d-CCK) w...

journal_title：Peptides

authors： Schwartz GJ,Moran TH,McHugh PR

更新日期：1990-11-01 00:00:00

abstract：:The levels of rat plasma beta-endorphin-like immunoreactivity following a 30 min exposure to (1) an unfamiliar operant chamber, (2) an unfamiliar operant chamber providing a VI-5 second schedule of 3 mA, 1 sec footshocks, or (3) a familiar chamber providing no shocks, but previously paired with unavoidable shocks were...

journal_title：Peptides

authors： Scallet AC

更新日期：1982-03-01 00:00:00

abstract：:The binding of monoiodo 125I-Trp11-neurotensin to purified rat gastric fundus smooth muscle plasma membranes was characterized. Specific binding of ligand in subcellular fractions from rat fundus smooth muscle showed a distribution that paralleled that of several plasma membrane marker enzymes. 125I-Trp11-neurotensin ...

journal_title：Peptides

authors： Kitabgi P,Kwan CY,Fox JE,Vincent JP

更新日期：1984-09-01 00:00:00

abstract：:We are interested in the presence and function in insects of neuropeptides related to the vertebrate tachykinins. Hence, we have used antisera raised against the tachykinins substance P and kassinin, and against the insect neuropeptide leucokinin I, for localization studies and immunochemical analysis of related pepti...

journal_title：Peptides

authors： Lundquist CT,Brodin E,Muren JE,Nässel DR

更新日期：1993-07-01 00:00:00

abstract：:Sex pheromone biosynthesis in many moth species is controlled by a cerebral neuropeptide, termed pheromone biosynthesis activating neuropeptide (PBAN). PBAN is a 33 amino acid C-terminally amidated neuropeptide that is produced by neuroendocrine cells of the subesophageal ganglion (SEG). Studies of the regulation of s...

journal_title：Peptides

authors： Altstein M

更新日期：2004-09-01 00:00:00

abstract：:Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity...

journal_title：Peptides

authors： Hylden JL,Wilcox GL

更新日期：1983-07-01 00:00:00

abstract：:The binding and internalization of a cytotoxic analogue of luteinizing hormone-releasing hormone (LH-RH), T-98 (agonist [D-Lys6]LH-RH linked to glutaryl-2-(hydroxymethyl)anthraquinone), by rat anterior pituitary cells was investigated. Analogue T-98 was bound to pituitary membrane binding sites for LH-RH with a high a...

journal_title：Peptides

authors： Szöke B,Horváth J,Halmos G,Rékási Z,Groot K,Nagy A,Schally AV

更新日期：1994-01-01 00:00:00

abstract：:It is well known that glucoprivation induces the release of counterregulatory hormones such as glucagon, and that the response is attenuated when the stimuli are repeated. Glucoprivation also activates orexigenic neurons and induces hyperphagic responses, although it remains unclear whether these responses are attenua...

journal_title：Peptides

authors： Ozawa Y,Arima H,Watanabe M,Shimizu H,Ito Y,Banno R,Sugimura Y,Ozaki N,Nagasaki H,Oiso Y

更新日期：2011-04-01 00:00:00

abstract：:Cardiac hypertrophy, an adaptive process to an increased hemodynamic overload, includes not only an increase in cell size but also qualitative changes in constituent proteins. Although swelling-activated chloride channels (I(Cl,swell)) chronically activate in hypertrophied atrial myocytes, the role of I(Cl,swell) in r...

journal_title：Peptides

authors： Bai GY,Yuan K,Park WH,Kim SZ,Kim SH

更新日期：2008-09-01 00:00:00

abstract：:Ceratotoxin A (CtxA), a 36-residue alpha-helical cationic peptide isolated from the medfly Ceratitis capitata, exhibits strong antibacterial activity. To determine its mode of action against bacteria, we investigated the behavior of ceratotoxin A by incorporating it into planar lipid bilayers. Macroscopic and single c...

journal_title：Peptides

authors： Saint N,Marri L,Marchini D,Molle G

更新日期：2003-11-01 00:00:00

abstract：:Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...

journal_title：Peptides

authors： Wewer Albrechtsen NJ

更新日期：2018-02-01 00:00:00

abstract：:Just as the blood-brain barrier (BBB) is not a static barrier, the adipocytes are not inert storage depots. Adipokines are peptides or polypeptides produced by white adipose tissue; they play important roles in normal physiology as well as in the metabolic syndrome. Adipokines secreted into the circulation can interac...

journal_title：Peptides

authors： Pan W,Kastin AJ

更新日期：2007-06-01 00:00:00

abstract：:Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), an endogenous mammalian antiopioid peptide, has been shown by other laboratories to attenuate the acute antinociceptive effects of morphine, the development of morphine tolerance, and naloxone-induced withdrawal in morphine-dependent rats. The present study determined the ef...

journal_title：Peptides

authors： Rothman RB,Brady LS,Xu H,Long JB

更新日期：1993-11-01 00:00:00

abstract：:VIP stimulates adenylate cyclase activity of male and female rat anterior pituitaries and human prolactinomas, while dopamine inhibits the enzyme activity of female rat pituitaries and prolactinomas. A dopamine inhibited cyclase can be detected also in male rats provided the enzyme activity is increased by VIP. The an...

journal_title：Peptides

authors： Oliva D,Vallar L,Giannattasio G,Spada A,Nicosia S

更新日期：1984-11-01 00:00:00

abstract：:Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...

journal_title：Peptides

authors： Verdon J,Berjeaud JM,Lacombe C,Héchard Y

更新日期：2008-06-01 00:00:00

abstract：:The distribution and chemical properties of compounds with tachykinin-like immunoreactivity (TK-LI) in the spinal cord and brain of lampreys (Lampetra fluviatilis and Ichthyomyzon unicuspis) were investigated by means of immunohistochemistry and various chromatographic methods combined with radioimmunoassay. The distr...

journal_title：Peptides

authors： Van Dongen PA,Theodorsson-Norheim E,Brodin E,Hökfelt T,Grillner S,Peters A,Cuello AC,Forssmann WG,Reinecke M,Singer EA

更新日期：1986-03-01 00:00:00

abstract：:The effects of CCK-8s and desulfated CCK-8 at concentrations ranging from 10(-14) to 10(-6) M were studied in vitro on several functions of human peripheral neutrophils: adherence to substrate, mobility (spontaneous and directed by a chemical gradient or chemotaxis), ingestion of inert particles (latex beads) or cells...

journal_title：Peptides

authors： Carrasco M,Del Rio M,Hernanz A,De la Fuente M

更新日期：1997-01-01 00:00:00

abstract：:Although enterostatin (VPDPR) inhibited morphine-induced analgesia, it had no affinity for mu-opioid receptors. VPDPR administration was reported to elevate serum corticosterone levels. We found that corticosterone exhibited a similar anti-analgesic effect selective for mu-opioid. Furthermore, the anti-analgesic effec...

journal_title：Peptides

authors： Takenaka Y,Nakamura F,Usui H,Lipkowski AW,Toth G,Yoshikawa M

更新日期：2003-05-01 00:00:00

abstract：:The immunoregulatory role of methionine-enkephalin (Met-enk) is well studied in mammals, but has not been explored in ectotherms despite the fact that this peptide is highly conserved in vertebrates. The present study demonstrates the diverse effects of Met-enk depending on its concentration and specific function of s...

journal_title：Peptides

authors： Singh R,Rai U

更新日期：2009-06-01 00:00:00

abstract：:Human beta-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune system that serves as antimicrobial molecule. We determined the bactericidal activity of synthetic hBD-2 against nosocomial strains belonging to eight different bacterial species and exhibiting various antimicrobial resistance pheno...

journal_title：Peptides

authors： Routsias JG,Karagounis P,Parvulesku G,Legakis NJ,Tsakris A

更新日期：2010-09-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and endothelin (ET) are endogenous vasoactive factors that exert potent diuretic and natriuretic actions. We have previously shown that ANP and ET-3 act through an NO pathway to inhibit the sodium-glucose cotransporter (SGLT) in the intestine [Gonzalez Bosc LV, Elustondo PA, Ortiz MC, ...

journal_title：Peptides

authors： Majowicz MP,Gonzalez Bosc LV,Albertoni Borghese MF,Delgado MF,Ortiz MC,Sterin Speziale N,Vidal NA

更新日期：2003-12-01 00:00:00

abstract：:Cone snails have evolved an assortment of venom peptides as an evolutionary strategy for rapid prey immobilization and defence. Earlier studies estimated approximately 100 conopeptides per species. In this study we optimized liquid chromatography and electrospray ionization mass spectrometry for the detection of conop...

journal_title：Peptides

authors： Davis J,Jones A,Lewis RJ

更新日期：2009-07-01 00:00:00

abstract：:In the epileptic brain, hippocampal dentate granule cells become synaptically interconnected through the sprouting of mossy fibers. This new circuitry is expected to facilitate epileptiform discharge. Prolonged seizures induce the long-lasting neoexpression of neuropeptide Y (NPY) in mossy fibers. NPY is released spon...

journal_title：Peptides

authors： Nadler JV,Tu B,Timofeeva O,Jiao Y,Herzog H

更新日期：2007-02-01 00:00:00

abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...

journal_title：Peptides

authors： Sample CJ,Hudak KE,Barefoot BE,Koci MD,Wanyonyi MS,Abraham S,Staats HF,Ramsburg EA

更新日期：2013-10-01 00:00:00

abstract：:Adjacent tissue sections through the rat median eminence were examined for the distribution of gonadotropin-releasing hormone (GnRH) and catecholamines (CA). A simultaneous visualization technique was employed for this correlative neuroanatomical analysis. At rostral and mid-central levels of the median eminence the m...

journal_title：Peptides

authors： McNeill TH,Scott DE,Sladek JR Jr

更新日期：1980-04-01 00:00:00

abstract：:Caudodorsal cell hormone-I (CDCH-I), a 36 amino acid peptide synthesized by the caudodorsal cells (CDCs), is one of the major neuropeptides present in the cerebral ganglia of the freshwater snail, Lymnaea stagnalis. This peptide induces ovulation and egg-mass formation, and, in addition, acts on neuronal circuits invo...

journal_title：Peptides

authors： Li KW,Geraerts WP,Joosse J

更新日期：1992-03-01 00:00:00

abstract：:The relaxant effect of a novel VIP analog, [Arg15,20,21Leu17]-VIP-Gly-Lys-Arg-NH2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analog caused significantly and concentration-dependent relaxation similarly to the original VIP. In contrast to the o...

journal_title：Peptides

authors： Yoshihara S,Lindén A,Kashimoto K,Watanabe S

更新日期：1998-01-01 00:00:00