Abstract:
:The relaxant effect of a novel VIP analog, [Arg15,20,21Leu17]-VIP-Gly-Lys-Arg-NH2 was compared with that of the original VIP in the same guinea pig trachea precontracted by carbachol in vitro. The VIP analog caused significantly and concentration-dependent relaxation similarly to the original VIP. In contrast to the original VIP, the VIP analog demonstrated a slow onset and offset of action, with more than 90% of its maximum relaxation remaining 6 h after administration. Peptidase inhibition by captopril and phosphoramidon increased the relaxant effect and duration of action for original VIP but not for the VIP analog.
journal_name
Peptidesjournal_title
Peptidesauthors
Yoshihara S,Lindén A,Kashimoto K,Watanabe Sdoi
10.1016/s0196-9781(97)00457-9subject
Has Abstractpub_date
1998-01-01 00:00:00pages
593-7issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(97)00457-9journal_volume
19pub_type
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