Abstract:
:The aim of this study was to compare the actions of CCK neuropeptides within the nucleus accumbens (N.Acc) of alcohol preferring (Fawn-Hooded, FH) and alcohol nonpreferring (Wistar-Kyoto, WKY) rats. CCK-8S (30-300 nM) facilitated the K(+) stimulated release of [(3)H]dopamine (DA) from N.Acc prisms in both rat strains, whereas CCK-4 (30 nM-1 microM) caused a significant decrease of evoked [(3)H]DA in the FH rat only. A scattered distribution of CCK-A and -B receptor immunopositive varicose fibers were visualized throughout the N.Acc of both rat strains along with a topographic distribution of CCK receptor positive cells throughout the ventral mesencephalon.
journal_name
Peptidesjournal_title
Peptidesauthors
Lodge DJ,Short JL,Mercer LD,Beart PM,Lawrence AJdoi
10.1016/s0196-9781(00)00159-5subject
Has Abstractpub_date
2000-03-01 00:00:00pages
379-86issue
3eissn
0196-9781issn
1873-5169pii
S0196-9781(00)00159-5journal_volume
21pub_type
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