Abstract:
:Previous studies have shown that the nervous system and other tissues of molluscs contain a number of peptides that potently excite molluscan hearts. Two such peptides, termed small cardioactive peptides A and B (SCPA and SCPB) are present in large quantities in the nervous system of Aplysia. These peptides are widely distributed within the CNS and peripheral tissues and have been found to be potent modulators of synaptic transmission in Aplysia. SCPB has previously been purified from nervous tissue and sequenced. In this paper, we report the purification of SCPA and propose its sequence. This sequence was confirmed by comparing the chromatographic properties of native SCPA (labelled in organ culture) with a synthetic peptide that has the proposed sequence. A significant proportion of the sequence of the two SCPs is conserved, indicating that they are members of the same peptide class, a finding that is consistent with the recent observation that the two peptide sequences are present in a single precursor.
journal_name
Peptidesjournal_title
Peptidesauthors
Lloyd PE,Kupfermann I,Weiss KRdoi
10.1016/0196-9781(87)90184-7subject
Has Abstractpub_date
1987-01-01 00:00:00pages
179-84issue
1eissn
0196-9781issn
1873-5169pii
0196-9781(87)90184-7journal_volume
8pub_type
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