Abstract：
:The 41-residue corticotropin releasing factor (CRF) was synthesized by the solid phase method. The synthetic CRF and arginine vasopressin (AVP) were examined for ACTH releasing activity and effects on the release of 5 other pituitary hormones in vivo and in vitro. Injection of the CRF into pharmacologically blocked rats increased plasma corticosterone levels in a dose-related manner. The minimum effective dose was 1.6 x 10(-12) mol/100 g body weight. CRF also significantly stimulated release of ACTH-like immunoreactivity in a dose-related manner from rat pituitary quarters beginning at a concentration of 10(-9) M. AVP, a peptide known to have CRF activity, exhibited slightly lower corticotropin releasing activity than the CRF at equimolar dose levels. Secretion of other pituitary hormones was not appreciably altered by either the CRF or AVP.
journal_name
Peptidesjournal_title
Peptidesauthors
Turkelson CM,Arimura A,Culler MD,Fishback JB,Groot K,Kanda M,Luciano M,Thomas CR,Chang D,Chang JK,Shimizu Mdoi
10.1016/s0196-9781(81)80099-xsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
425-9issue
4eissn
0196-9781issn
1873-5169pii
S0196-9781(81)80099-Xjournal_volume
2pub_type
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