Abstract:
:We have studied the in vitro effect of VIP and histamine on ultrastructure of the parietal cells in isolated guinea pig fundic glands. The morphological changes induced by histamine in the parietal cells can be compared to those observed after histamine stimulation in vivo or in vitro on gastric mucosa preparations. In contrast, VIP incubation did not produce the ultrastructural changes related to gastric acid secretion, in resting parietal cells. Pretreatment of the glands by VIP resulted in a remarkable suppression of the histamine effect, since the parietal cells assumed an almost resting state. The data (1) indicate that the parietal cells in isolated gastric glands of the guinea pig retain in vitro the capacity to undergo the ultrastructural changes that are related to acid secretion in vivo after histamine or cAMP and (2) suggest that VIP is an inhibitor of histamine-induced gastric acid secretion in the guinea pig. It is proposed that VIP could act directly on the parietal cell via cAMP-phosphodiesterase activation, or indirectly via gastric somatostatin and/or prostaglandin secretions, inhibiting the H2 receptor-cAMP system of the parietal cell.
journal_name
Peptidesjournal_title
Peptidesauthors
Anteunis A,Gespach C,Astesano A,Emami S,Robineaux R,Rosselin Gdoi
10.1016/0196-9781(84)90219-5subject
Has Abstractpub_date
1984-03-01 00:00:00pages
277-83issue
2eissn
0196-9781issn
1873-5169pii
0196-9781(84)90219-5journal_volume
5pub_type
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