The cationic tetradecapeptide mastoparan as a privileged structure for drug discovery: Enhanced antimicrobial properties of mitoparan analogues modified at position-14.

abstract：:A series of Locusta adipokinetic hormone I (AKH-I), < QLNFTPNWGTa, analogues, were synthesized with modifications at the C-terminal threonine residue using a combination of solid- and liquid-phase methodology and evaluated in Locusta migratoria, in a lipid mobilization assay in vivo and an acetate uptake assay in vitr...

journal_title：Peptides

authors： Lee MJ,Goldsworthy GJ,Poulos CP,Velentza A

更新日期：1996-01-01 00:00:00

abstract：:Male Holtzman albino and Long-Evans hooded rats were administered one microgram of arginine vasopressin (AVP) or a placebo each day after the acquisition trials of a visual white-black discrimination. Animals were then trained in the reversal of the discrimination. Performance was assessed by the number of trials to c...

journal_title：Peptides

authors： Tinius TP,Beckwith BE,Oltmanns D

更新日期：1989-01-01 00:00:00

abstract：:Host-defense peptides secreted by epithelial cells exhibit cytotoxic and immunoregulatory effects in order to protect the organism against invading microorganisms. Antimicrobial peptides derived from frog skin display both immunostimulatory and immunosuppressive actions as demonstrated by in vitro cytokine production ...

journal_title：Peptides

authors： Pantic JM,Radosavljevic GD,Jovanovic IP,Arsenijevic NN,Conlon JM,Lukic ML

更新日期：2015-09-01 00:00:00

abstract：:Angiotensin IV (Ang IV) is formed by aminopeptidase N from Ang III by removing the first N-terminal amino acid. Previously, we reported that Ang III has some cardioprotective effects against global ischemia in Langendorff heart. However, it is not clear whether Ang IV has cardioprotective effects. The aim of the prese...

journal_title：Peptides

authors： Park BM,Cha SA,Lee SH,Kim SH

更新日期：2016-05-01 00:00:00

abstract：:Bradykinin (BK) has been proposed as the principal mediator of hypersensitivity reactions (HSR) in patients dialyzed using negatively charged membranes and concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors. We investigated the metabolism of exogenous BK added to the sera of 13 patients dialyzed...

journal_title：Peptides

authors： Blais C Jr,Marc-Aurèle J,Simmons WH,Loute G,Thibault P,Skidgel RA,Adam A

更新日期：1999-01-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a potent orexigenic and sleep-promoting neuropeptide in mammals produced predominately by hypothalamic neurons which project to a wide variety of brain areas. Several MCH producing neurons contain MCH as the only neuropeptide, while others comprise cocaine- and amphetamine regula...

journal_title：Peptides

authors： Jancsik V,Bene R,Sótonyi P,Zachar G

更新日期：2018-01-01 00:00:00

abstract：:The distributions of neuropeptides in paraffin-embedded tissue sections (PETS) of the eyestalk, brain, and thoracic ganglia of the shrimp Penaeus monodon were visualized by imaging mass spectrometry (IMS). Peptide signals were obtained from PETS without affecting morphological features. Twenty-nine neuropeptides compr...

journal_title：Peptides

authors： Chansela P,Goto-Inoue N,Zaima N,Sroyraya M,Sobhon P,Setou M

更新日期：2012-03-01 00:00:00

abstract：:Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...

journal_title：Peptides

authors： Muraki K,Mitra SP,Dobner PR,Carraway RE

更新日期：1993-11-01 00:00:00

abstract：:The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...

journal_title：Peptides

authors： Pournajafi-Nazarloo H,Kenkel W,Mohsenpour SR,Sanzenbacher L,Saadat H,Partoo L,Yee J,Azizi F,Carter CS

更新日期：2013-05-01 00:00:00

abstract：:Cholecystokinin induces a reduction in exploratory behaviors which could reflect an underlying behavioral state of either satiety or malaise. To investigate these alternative hypotheses, the effects of CCK were compared to the effects of (a) consumption of an extra quantity of palatable food, of (b) bombesin at doses ...

journal_title：Peptides

authors： Crawley JN

更新日期：1983-07-01 00:00:00

abstract：:As part of a continuing search for potential anticancer drug candidates from antimicrobial peptides of marine organisms, tilapia (Oreochromis mossambicus) hepcidin TH2-3 was evaluated in several tumor cell lines. The results indicated that TH2-3, a synthetic 20-mer antimicrobial peptide, specifically inhibited human f...

journal_title：Peptides

authors： Chen JY,Lin WJ,Lin TL

更新日期：2009-09-01 00:00:00

abstract：:Using autoradiographic method and 125I-Tyro rat CGRP as a ligand, receptor binding sites were demonstrated in the rat central nervous system. Saturation studies and Scatchard analysis of CGRP-binding to slide mounted tissue sections containing primarily cerebellum showed a single class of receptors with a dissociation...

journal_title：Peptides

authors： Skofitsch G,Jacobowitz DM

更新日期：1985-09-01 00:00:00

abstract：:There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U...

journal_title：Peptides

authors： Momose K,Inui A,Asakawa A,Ueno N,Nakajima M,Kasuga M

更新日期：1998-01-01 00:00:00

abstract：:WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...

journal_title：Peptides

authors： Gao Z,Wang S,Qi G,Pan H,Zhang L,Zhou X,Liu J,Zhao X,Wu J

更新日期：2012-11-01 00:00:00

abstract：:We studied the ability of NPFF, a FMRFamide-like peptide with certain antiopiate properties, to affect the inhibitory effect of morphine on the electrically induced contraction of guinea pig ileum. Neuropeptide FF had no effect when administered alone but reduced morphine inhibition in a noncompetitive manner. Neurope...

journal_title：Peptides

authors： Demichel P,Rodriguez JC,Roquebert J,Simonnet G

更新日期：1993-09-01 00:00:00

abstract：:Neuronostatin is a 13-amino acid amidated peptide widely distributed in various organs including gastrointestinal tract. However, the effect of neuronostatin on gastrointestinal motility has not been well characterized. In the present work, effects of central administration of neuronostatin on gastric emptying and gas...

journal_title：Peptides

authors： Su SF,Yang AM,Yang SB,Wang NB,Lu SS,Wang HH,Chen Q

更新日期：2012-05-01 00:00:00

abstract：:Previous studies have shown that different calcitonins interact with planar lipid membranes to form ion channels. In this study, glycosylation of eel calcitonin (eCt) at different positions (Ct3-GlcNAc, Ct14-GlcNAc, Ct20-GlcNAc, Ct26-GlcNAc) is shown to preserve molecular structure and slightly change the energy of in...

journal_title：Peptides

authors： Meleleo D,Micelli S,Toma K,Haneda K,Gallucci E

更新日期：2006-04-01 00:00:00

abstract：:Bradykinin-potentiating peptides from Bothrops jararaca (Bj) discovered in the early 1960s, were the first natural inhibitors of the angiotensin-converting enzyme (ACE). These peptides belong to a large family of snake venom proline-rich oligopeptides (PROs). One of these peptides, Bj-PRO-9a, was essential for definin...

journal_title：Peptides

authors： Morais KL,Ianzer D,Miranda JR,Melo RL,Guerreiro JR,Santos RA,Ulrich H,Lameu C

更新日期：2013-10-01 00:00:00

abstract：:The in vitro interaction between five polycationic peptides, buforin II, cecropin P1, indolicidin, magainin II, and ranalexin, and several clinically used antimicrobial agents was evaluated against several clinical isolates of Gram-positive and Gram-negative aerobic bacteria, using the microbroth dilution method. The ...

journal_title：Peptides

authors： Giacometti A,Cirioni O,Del Prete MS,Paggi AM,D'Errico MM,Scalise G

更新日期：2000-08-01 00:00:00

abstract：:Increased plasma levels of neuropeptide Y (NPY)-like immunoreactivity (p-NPY-LI) have been described in hemodialysis (HD) patients. In this investigation the effect of a standard HD on p-NPY-LI, analyzed by radioimmunoassay and reverse-phase high performance liquid chromatography (HPLC), was studied. During dialysis p...

journal_title：Peptides

authors： Hegbrant J,Thysell H,Ekman R

更新日期：1995-01-01 00:00:00

abstract：:We produced and characterized three anti-C-flanking peptides of neuropeptide Y (CPON) monoclonal antibodies. The Ka for these antibodies ranged from 0.4 to 0.8 x 10(8) l/mol with an IC50 for CPON(1-30) at about 20 nM as determined by ELISA. All these antibodies are IgG1 and recognize the 16-30 part of CPON. These anti...

journal_title：Peptides

authors： Grouzmann E,Alvarez-Bolado G,Meyer C,Osterheld MC,Burnier M,Brunner HR,Waeber B

更新日期：1994-01-01 00:00:00

abstract：:Plant defensins are a prominent family of cationic peptides in the plant kingdom. They are structurally and functionally related to defensins that have been previously characterized in mammals and insects. They present molecular masses between 5 and 7kDa and possess a pattern of eight conserved Cys residues. The three...

journal_title：Peptides

authors： Carvalho Ade O,Gomes VM

更新日期：2009-05-01 00:00:00

abstract：:Lipocalin-2 (LCN-2), a peptide with diverse expression pattern, has been identified as a biomarker of various diseases as well as a factor contributing to inflammatory responses associated with excess adiposity and ensuing metabolic disorders. Although the inter-relationship between LCN-2 and excess adiposity is incre...

journal_title：Peptides

authors： Singh RG,Nguyen NN,Cervantes A,Kim JU,Stuart CE,Petrov MS

更新日期：2019-09-01 00:00:00

abstract：:Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...

journal_title：Peptides

authors： Ceriotti S,Consiglio AL,Casati L,Cremonesi F,Sibilia V,Ferrucci F

更新日期：2018-05-01 00:00:00

abstract：:Apamin is a neurotoxic octadecapeptide from bee venom, which has been shown to inhibit the non-adrenergic, non-cholinergic inhibitory innervation of the smooth muscle of the gut. Since vasoactive intestinal polypeptide (VIP) has been proposed as a possible inhibitory neurotransmitter, the effect of apamin on the recep...

journal_title：Peptides

authors： Fahrenkrug J,Gammeltoft S,Staun-Olsen P,Ottesen B,Sjöquist A

更新日期：1983-03-01 00:00:00

abstract：:Peptides are important regulators of growth and cellular functions not only in normal tissue but also in tumors. So they are becoming radioligands of increasing interest in nuclear oncology for targeted tumor diagnosis and therapy. So development of new peptide radiopharmaceuticals is becoming one of the most importan...

journal_title：Peptides

authors： Chandra S,De K,Ganguly S,Sarkar B,Misra M

更新日期：2009-12-01 00:00:00

abstract：:Adjacent tissue sections through the rat median eminence were examined for the distribution of gonadotropin-releasing hormone (GnRH) and catecholamines (CA). A simultaneous visualization technique was employed for this correlative neuroanatomical analysis. At rostral and mid-central levels of the median eminence the m...

journal_title：Peptides

authors： McNeill TH,Scott DE,Sladek JR Jr

更新日期：1980-04-01 00:00:00

abstract：:CRF system, structural conservation, has an association with feeding regulation in mammals. However, mammals and fish have different physiological mechanisms, the potential role of CRF system for feeding regulation in teleost fish are most unknown. To better explore possible feeding mechanisms of CRF system in Acipens...

journal_title：Peptides

authors： Qi J,Xu S,Wang M,Chen H,Tang N,Wang B,Li Y,Zhang X,Chen D,Zhou B,Zhao L,Wang Y,Li Z

更新日期：2020-06-01 00:00:00

abstract：:By immunohistochemistry it was found that PHI- and VIP-like immunoreactivity (-IR) occurred in the same autonomic neurons in the upper respiratory tract, tongue and salivary glands with associated ganglia in rat, guinea-pig, cat, pig and man. VIP- and PHI-like immunoreactivity was also found in similar locations in th...

journal_title：Peptides

authors： Lundberg JM,Fahrenkrug J,Hökfelt T,Martling CR,Larsson O,Tatemoto K,Anggård A

更新日期：1984-05-01 00:00:00

abstract：:Vascular permeability and endothelial cell damage has been shown to occur in rats subjected to trauma with hemorrhagic-shock. Although the factors responsible for the endothelial cell injury are unknown, it has been hypothesized that toxic factors produced in response to hemorrhagic-shock originate in the gut and are ...

journal_title：Peptides

authors： Kaiser VL,Sifri ZC,Senthil M,Dikdan GS,Lu Q,Xu DZ,Deitch EA

更新日期：2005-12-01 00:00:00