Abstract:
:There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U-shaped dose response. To determine whether the anxiolytic effect of motilin was mediated via motilin receptors in the brain, the effect of GM-109, a novel motilin receptor antagonist, was investigated. GM-109 showed a significant and dose-dependent antagonism on the motilin-induced anxiolytic effect. GM-109 administered alone had no effect on anxiety. These results suggest that motilin receptors are present in the brain and may have a role in anxiety and emotion.
journal_name
Peptidesjournal_title
Peptidesauthors
Momose K,Inui A,Asakawa A,Ueno N,Nakajima M,Kasuga Mdoi
10.1016/s0196-9781(98)00131-4subject
Has Abstractpub_date
1998-01-01 00:00:00pages
1739-42issue
10eissn
0196-9781issn
1873-5169pii
S0196-9781(98)00131-4journal_volume
19pub_type
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