Abstract：
:Dendroaspis natriuretic peptide (DNP) is one of four members of the natriuretic peptide family sharing functional and structural properties. The purpose of the present study was to elucidate the physiological role of DNP on renal functions and its cellular mechanism in the rabbit kidney. DNP (5 μg/kg/min) infused intravenously increased urine volume and urinary excretion of electrolytes. These renal actions induced by DNP were more pronounced than those caused by atrial natriuretic peptide (ANP). We compared profiles of (125)I-ANP and (125)I-DNP by reverse-phase HPLC during incubation in rabbit plasma at 37°C for 1, 2, and 4h. While (125)I-ANP was quickly degraded within 1h, (125)I-DNP was still stable in plasma for 4h. DNP induced the greatest cyclic guanosine monophosphate (cGMP) production in the glomeruli in a dose-dependent manner, when compared to other renal structures including cortical tubules, outer medullary tubules, and inner medullary tubules. Affinity cross-linking analysis revealed NPR-A is selective receptor for DNP in glomeruli. Forskolin, a stimulator of adenylyl cyclase, significantly decreased cGMP production in the renal glomeruli but not in the renal medulla. In summary, DNP is a more effective activator of renal functions than ANP, possibly because of the degradation resistance of DNP against the endogenous peptidases in plasma or tissues. These findings suggest that DNP plays a pivotal role as a renal regulating peptide via specific natriuretic peptide receptors with a guanylyl cyclase domain.
journal_name
Peptidesjournal_title
Peptidesauthors
Kim SM,Kim SY,Kim SH,Cho KW,Kim SZdoi
10.1016/j.peptides.2011.12.006subject
Has Abstractpub_date
2012-01-01 00:00:00pages
59-66issue
1eissn
0196-9781issn
1873-5169pii
S0196-9781(11)00517-1journal_volume
33pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:This paper reviews aspects of our research, focusing on the role of the melanocortin system in the central regulation of feeding and energy balance, which was begun in 1997. It describes data from successive physiological studies, concerning the identity of the appetite-regulating melanocortin receptor, melanocortin-4...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2005.01.030
更新日期：2006-02-01 00:00:00
abstract：:Phalloidin staining F-actin was used to image muscle fiber arrangements present in the reproductive system of the adult female Rhodnius prolixus. A mesh of muscle fibers encircles the ovaries whereas a criss-cross pattern of finer muscle fibers covers each ovariole. Two layers of muscle fibers (arranged longitudinally...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.04.003
更新日期：2014-03-01 00:00:00
abstract：:Recent refinements in methodology now permit the study of endogenous peptide hormones in their individual target cells. The investigations reported here deal with the question of whether endogenous ACTH can be detected in its target cells in the highly active adrenal gland of the normally lactating rat. This question ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(80)90062-5
更新日期：1980-10-01 00:00:00
abstract：:The binding activity of several galanin fragments and analogs was measured on specific receptors present in rat brain and the rat pancreatic beta cell line Rin m 5F. In both tissues it was observed that: 1) galanin(3-29), galanin(10-29) and [Ile2]-galanin were ineffective for inhibiting [125I] galanin binding and 2) a...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90109-5
更新日期：1989-07-01 00:00:00
abstract：:The detection of the prodynorphin gene in anuran amphibians and lungfishes may indicate that this gene arose as a result of the duplication of the proenkephalin gene early during the divergence of the Sarcopterygii, or that this gene may predate the divergence of the ray-finned fish and the lobe-finned fish. The cloni...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.09.007
更新日期：2006-04-01 00:00:00
abstract：:The elevated T-maze was combined with a free exploration protocol, which, in contrast to the conventional procedure, dispenses with handling of the animals during the experimental sessions. This allows measurement of fear indexes derived from the elevated plus-maze as well as assessment of acquisition of open arm avoi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00421-1
更新日期：2001-07-01 00:00:00
abstract：:The aim was to study the effects of C-type natriuretic peptide (CNP) on mean arterial pressure (MAP) and the cardiovascular nitric oxide (NO) system in spontaneously hypertensive rats (SHR), and to investigate the signaling pathways involved in this interaction. SHR and WKY rats were infused with saline or CNP. MAP an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.03.030
更新日期：2010-07-01 00:00:00
abstract：:Of twelve dipeptides tested, only the Trp containing peptides Val-Trp and its reverse peptide Trp-Val showed a xanthine oxidase (XO) inhibitory activity. Studies with Val and Trp revealed that XO inhibition was mainly attributed to the Trp residue. No significant difference (P ≥ 0.05) was found for the XO inhibitory p...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.07.030
更新日期：2012-10-01 00:00:00
abstract：:This study was designed to investigate the effects of synthetic mouse pancreatic polypeptide (mPP) on feeding and anxiety in mice. The intracerebroventricular (i.c.v.) injection of mPP (0.003-3 nmol) dose-dependently increased food intake. A significant increase was observed 20 min after i.c.v. injection and continued...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00155-2
更新日期：1999-12-01 00:00:00
abstract：:Imidazole-related dipeptides, such as carnosine and anserine, occur widely in skeletal muscles of jawed vertebrates. All of the known enzymes that catalyze the hydrolysis of these dipeptides belong to the M20A metallopeptidase subfamily; two secretory enzymes, serum carnosinase (EC 3.4.13.20) and anserinase (EC 3.4.13...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.01.008
更新日期：2011-04-01 00:00:00
abstract：:A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90230-m
更新日期：1991-11-01 00:00:00
abstract：:Kyotorphin is a unique biologically active neuropeptide (l-tyrosine-l-arginine), which is reported to have opioid-like analgesic actions through a release of Met-enkephalin from the brain slices. N-methyl-l-tyrosine-l-arginine (NMYR), an enzymatically stable mimetic of kyotorphin, successfully caused potent analgesic ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.06.010
更新日期：2018-09-01 00:00:00
abstract：:A neuropeptide F (NPF) was isolated from the fruit fly, Drosophila mellanogaster, based on a radioimmunoassay for a gut peptide from the corn earworm, Helicoverpa zea. A partial sequence was obtained from the fly peptide, and a genomic sequence coding for NPF was cloned after inverse polymerase chain reaction and show...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00097-2
更新日期：1999-01-01 00:00:00
abstract：:We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitative...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(83)90083-9
更新日期：1983-11-01 00:00:00
abstract：:Immunocytochemistry using an antiserum to the C-terminal octapeptide of synenkephalin, proenkephalin(63-70), was performed throughout the rat brain and revealed numerous immunopositive fibers and some cell bodies. The morphology and distribution of synenkephalin immunoreactivity was extremely similar to that of a comm...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90018-1
更新日期：1989-11-01 00:00:00
abstract：:I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00182-4
更新日期：1997-01-01 00:00:00
abstract：:In a previous study, we found that calcitonin gene-related peptide (CGRP) could be induced by proinflammatory factor IL-1beta in A549 human type II alveolar (AEII) epithelial cells. We investigated the mechanism of IL-1beta-induced CGRP secretion and found that the PKC-p38 MAPK-NF-kappaB pathway was involved. In the p...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.03.021
更新日期：2007-06-01 00:00:00
abstract：:The oligopeptide transporter (PepT1) is located on the brush-border membrane of the intestinal epithelium which has been regarded as a mediator of protein absorption. Here, we cloned and characterized PepT1 genes from diploid (red crucian carp), triploid and tetraploid fish. Then, the PepT1 expression pattern in diffe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.12.017
更新日期：2014-02-01 00:00:00
abstract：:The multifunctional arthropod 'insect kinins' share the evolutionarily conserved C-terminal pentapeptide motif Phe-X1-X2-Trp-Gly-NH2, where X1=His, Asn, Ser, or Tyr and X2=Ser, Pro, or Ala. Eight different analogs of the insect kinin C-terminal pentapeptide active core in which the critical residues Phe 1, Pro3 and Tr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.07.034
更新日期：2008-02-01 00:00:00
abstract：:Nesfatin-1 is well established to reduce food intake upon brain injection in rats, while in mice its anorexigenic action and brain expression are largely unexplored. We characterized the influence of intracerebroventricular (icv) and peripheral (intraperitoneal, ip, subcutaneous, sc) injection of nesfatin-1 on dark ph...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.09.027
更新日期：2011-01-01 00:00:00
abstract：:Skh-AMP1 (GRTSKQELCTWERGSVRQADKTIAG) is an antifungal peptide isolated from Satureja khuzistanica which has been shown to have strong antifungal activity against Aspergillus and Candida species, but no obvious hemolytic effects or cell cytotoxicity in vitro. In the present study, Skh-AMP1 was synthesized, and its mode...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2019.170195
更新日期：2020-01-01 00:00:00
abstract：:Brain-derived neurotrophic factor-like neuropeptide is produced in the brain of the silk moth, Bombyx mori. Immunocytochemical studies of brain and retrocerebral complex of larvae, prepupae, pupae and adults showed that four pairs of median neurosecretory cells and six pairs of lateral neurosecretory cells which had d...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.07.005
更新日期：2004-11-01 00:00:00
abstract：:The renin-angiotensin system (RAS) is now recognized as an important modulator of body metabolic processes. The discovery of angiotensin-converting enzyme 2 (ACE2) has renewed interest in the potential therapeutic role of RAS modulation. Recent studies have pointed out the importance of the local balance between ACE/A...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2014.10.005
更新日期：2014-12-01 00:00:00
abstract：:Paramyosin of the pig-human parasite Taenia solium (TPmy) is a α-helical protein located on the worm surface that is suggested to fulfill an immunomodulatory role protecting the parasite against host immune system. Besides, in challenging experiments the protein shows a vaccine potential. These observations imply that...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.10.003
更新日期：2012-03-01 00:00:00
abstract：:Motilin-immunopositive cells (Mo cells) are known to be present in the upper small intestine of various species, including man. However, whether Mo cells are present in the rabbit gastrointestinal tract remained to be elucidated. Therefore, this study was designed to investigate the distribution of Mo cells in the rab...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(95)00046-m
更新日期：1995-01-01 00:00:00
abstract：:Urotensin II (UII) induces the development of cardiac remodeling and atherosclerosis by promoting hypertrophy of cardiomyocytes and mitogenesis of fibroblasts and vascular smooth muscle cells. But its effect on cardiac side population cells (CSPs), one of somatic stem cells, is unclear. The present study examined the ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.01.024
更新日期：2011-05-01 00:00:00
abstract：:Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90005-3
更新日期：1989-11-01 00:00:00
abstract：:In the present study, the newly synthesized TRH analog (L-pGlu-(2-propyl)-L-His-l-ProNH(2); NP-647) was evaluated for its effects in in vitro (oxygen glucose deprivation (OGD)-, glutamate- and H(2)O(2)-induced injury in PC-12 cells) and in vivo (transient global ischemia) models of cerebral ischemic injury. PC-12 cell...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.04.006
更新日期：2011-06-01 00:00:00
abstract：:Ghrelin, a novel gut hormone, has been shown to exert protective effects on cardiac dysfunction and remodeling. However, the underlying mechanisms of its protective effects remain unclear. Here, we investigated the effects of ghrelin on cardiac hypertrophy and explored the mechanisms involved. Ghrelin (30 μg.kg-1. day...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2020.170446
更新日期：2020-11-13 00:00:00
abstract：:An identical CRF-related diuretic peptide (Musca-DP) was isolated and characterized from whole-body extracts of the house fly, Musca domestica, and stable fly, Stomoxys calcitrans. The peptide stimulates cyclic AMP production in Manduca sexta Malpighian tubules and increases the rate of fluid secretion by isolated Mus...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(94)90059-0
更新日期：1994-01-01 00:00:00
