Isolation and characterization of a diuretic peptide common to the house fly and stable fly.


:An identical CRF-related diuretic peptide (Musca-DP) was isolated and characterized from whole-body extracts of the house fly, Musca domestica, and stable fly, Stomoxys calcitrans. The peptide stimulates cyclic AMP production in Manduca sexta Malpighian tubules and increases the rate of fluid secretion by isolated Musca domestica tubules. The 44-residue peptide, with a mol.wt. of 5180, is amidated, and has the primary structure: NKPSLSIVNPLDVLRQRLLLEIARRQMKENTRQVELNRAILKNV-NH2. Musca-DP has a high percentage of sequence identity with other characterized CRF-related insect diuretic peptides.






Clottens FL,Holman GM,Coast GM,Totty NF,Hayes TK,Kay I,Mallet AI,Wright MS,Chung JS,Truong O




Has Abstract,Author List Incomplete


1994-01-01 00:00:00
















  • Effect of eel calcitonin glycosylation on incorporation and channel formation in planar phospholipid membranes.

    abstract::Previous studies have shown that different calcitonins interact with planar lipid membranes to form ion channels. In this study, glycosylation of eel calcitonin (eCt) at different positions (Ct3-GlcNAc, Ct14-GlcNAc, Ct20-GlcNAc, Ct26-GlcNAc) is shown to preserve molecular structure and slightly change the energy of in...


    pub_type: 杂志文章


    authors: Meleleo D,Micelli S,Toma K,Haneda K,Gallucci E

    更新日期:2006-04-01 00:00:00

  • Inhibition of malaria parasite Plasmodium falciparum development by crotamine, a cell penetrating peptide from the snake venom.

    abstract::We show here that crotamine, a polypeptide from the South American rattlesnake venom with cell penetrating and selective anti-fungal and anti-tumoral properties, presents a potent anti-plasmodial activity in culture. Crotamine inhibits the development of the Plasmodium falciparum parasites in a dose-dependent manner [...


    pub_type: 杂志文章


    authors: El Chamy Maluf S,Dal Mas C,Oliveira EB,Melo PM,Carmona AK,Gazarini ML,Hayashi MA

    更新日期:2016-04-01 00:00:00

  • Exposure to chronic isolation modulates receptors mRNAs for oxytocin and vasopressin in the hypothalamus and heart.

    abstract::The goal of our study was to explore the effect of social isolation stress of varying durations on the plasma oxytocin (OT), messenger ribonucleic acid (mRNA) for oxytocin receptor (OTR), plasma arginine vasopressin (AVP) and mRNA for V1a receptor of AVP (V1aR) expression in the hypothalamus and heart of socially mono...


    pub_type: 杂志文章


    authors: Pournajafi-Nazarloo H,Kenkel W,Mohsenpour SR,Sanzenbacher L,Saadat H,Partoo L,Yee J,Azizi F,Carter CS

    更新日期:2013-05-01 00:00:00

  • Neuroendocrine implications for the association between cocaine- and amphetamine regulated transcript (CART) and hypophysiotropic thyrotropin-releasing hormone (TRH).

    abstract::Cocaine- and amphetamine regulated transcript (CART) is a recently discovered anorexigenic peptide, widely expressed in the central nervous system. Included among presumed hypothalamic mediated functions of CART are inhibition of food intake, stimulation of energy expenditure and regulation of hypothalamic-pituitary a...


    pub_type: 杂志文章,评审


    authors: Fekete C,Lechan RM

    更新日期:2006-08-01 00:00:00

  • Structure of equine corticotropin releasing factor.

    abstract::A 41 amino acid peptide, probably identical in structure to human corticotropin releasing factor, was isolated from 70 equine hypothalami by methanol extraction, immunoaffinity chromatography and single step of reverse phase HPLC. The amino acid sequence was determined by gas phase sequence analysis. Probable carboxyl...


    pub_type: 杂志文章


    authors: Livesey JH,Carne A,Irvine CH,Ellis J,Evans MJ,Smith R,Donald RA

    更新日期:1991-11-01 00:00:00

  • Arginine vasopressin in hypothalamic paraventricular nucleus is transferred to the caudate nucleus to participate in pain modulation.

    abstract::Arginine vasopressin (AVP), which is synthesized and secreted in the hypothalamic paraventricular nucleus (PVN), is the most important bioactive substance in the pain modulation. Our pervious study had shown that AVP plays an important role in pain modulation in caudate nucleus (CdN). The experiment was designed to in...


    pub_type: 杂志文章


    authors: Yang J,Li P,Zhang XY,Zhang J,Hao F,Pan YJ,Lu GZ,Lu L,Wang DX,Wang G,Yan FL

    更新日期:2011-01-01 00:00:00

  • Potentiation of the hypotensive effect of bradykinin by angiotensin-(1-7)-related peptides.

    abstract::In this study, we evaluated the bradykinin potentiating activity and ACE inhibitory activity of several Ang-(1-7)-related peptides: Ang-(2-7), Ang-(3-7), Ang-(4-7), Ang-(1-6), Ang-(1-5) and the selective antagonist of Ang-(1-7): D-[Ala7]Ang-(1-7) (A-779). In vivo experiments were performed in freely moving Wistar rats...


    pub_type: 杂志文章


    authors: Paula RD,Lima CV,Britto RR,Campagnole-Santos MJ,Khosla MC,Santos RA

    更新日期:1999-01-01 00:00:00

  • Inhibition of human neutrophil functions by sulfated and nonsulfated cholecystokinin octapeptides.

    abstract::The effects of CCK-8s and desulfated CCK-8 at concentrations ranging from 10(-14) to 10(-6) M were studied in vitro on several functions of human peripheral neutrophils: adherence to substrate, mobility (spontaneous and directed by a chemical gradient or chemotaxis), ingestion of inert particles (latex beads) or cells...


    pub_type: 杂志文章


    authors: Carrasco M,Del Rio M,Hernanz A,De la Fuente M

    更新日期:1997-01-01 00:00:00

  • Multiple Y receptors mediate pancreatic polypeptide responses in mouse colon mucosa.

    abstract::A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP...


    pub_type: 杂志文章


    authors: Cox HM,Pollock EL,Tough IR,Herzog H

    更新日期:2001-03-01 00:00:00

  • Effects of Pro-Leu-Gly-NH2 and cyclo (Leu-Gly) on the binding of 3H-quinuclidinyl benzilate to striatal cholinergic muscarinic receptors.

    abstract::The effects of Pro-Leu-Gly-NH2 (melanotropin release inhibiting factor, MIF) and its analog, cyclo (Leu-Gly) on the mouse and rat striatal cholinergic muscarinic receptors labeled with 3H-quinuclidinyl benzilate (QNB) were investigated. 3H-QNB bound to the rat striatal muscarinic receptors at a single high affinity si...


    pub_type: 杂志文章


    authors: Das S,Matwyshyn GA,Bhargava HN

    更新日期:1986-01-01 00:00:00

  • Distribution of two distinct messenger ribonucleic acids encoding gastrin-releasing peptide in rat brain.

    abstract::There are two distinct mRNAs that encode the precursor to gastrin-releasing peptide (GRP) in rat brain. These two messages arise from separate transcription initiation sites located approximately 400 base pairs apart, which are presumably regulated by separate promoters. In the present study, we mapped the distributio...


    pub_type: 杂志文章


    authors: Zoeller RT,Lebacq-Verheyden AM,Battey JF

    更新日期:1989-03-01 00:00:00

  • Neuromedins: novel smooth-muscle stimulating peptides identified in porcine spinal cord.

    abstract::Two novel peptides, neuromedin U-8 and U-25, eliciting a potent uterus stimulating activity, have been purified and identified in porcine spinal cord. Sequence analyses and syntheses revealed that neuromedin U-8 is a novel octapeptide with a C-terminal amide structure, while U-25 contains the U-8 sequence at its C-ter...


    pub_type: 杂志文章


    authors: Minamino N,Sudoh T,Kangawa K,Matsuo H

    更新日期:1985-01-01 00:00:00

  • Leptin receptor expressing neurons express phosphodiesterase-3B (PDE3B) and leptin induces STAT3 activation in PDE3B neurons in the mouse hypothalamus.

    abstract::Leptin signaling in the hypothalamus is critical for normal food intake and body weight regulation. Cumulative evidence suggests that besides the signal transducer and activator of transcription-3 (STAT3) pathway, several non-STAT3 pathways including the phosphodiesterase-3B (PDE3B) pathway mediate leptin signaling in...


    pub_type: 杂志文章


    authors: Sahu M,Sahu A

    更新日期:2015-11-01 00:00:00

  • Selective inhibition of the binding of 3H-(3-MeHis2) thyrotropin releasing hormone to rat amygdala membranes by some naturally occurring cannabinoids.

    abstract::The effect of naturally occurring cannabinoids, delta 9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the brain receptors for thyrotropin releasing hormone (TRH) was investigated. TRH receptors were labeled with 3H-(3-MeHis2)TRH (3H-MeTRH). 3H-MeTRH bound specifically to rat brain membranes at...


    pub_type: 杂志文章


    authors: Bhargava HN,Gulati A

    更新日期:1988-07-01 00:00:00

  • Bioactivities and secondary structure of mast cell degranulating (MCD) peptide analogs.

    abstract::Three analogs of Mast Cell Degranulating (MCD) peptide with C-terminal and one analog with N- and C-terminal deletions were synthesized and assayed for histamine-releasing activity in mast cells. Des(20-22)-MCD and des(21)-MCD markedly decreased this activity. In des(16-17,21)-MCD this activity was completely abolishe...


    pub_type: 杂志文章


    authors: Buku A,Maulik G,Hook WA

    更新日期:1998-01-01 00:00:00

  • Antimicrobial peptide KSL-W promotes gingival fibroblast healing properties in vitro.

    abstract::We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...


    pub_type: 杂志文章


    authors: Park HJ,Salem M,Semlali A,Leung KP,Rouabhia M

    更新日期:2017-07-01 00:00:00

  • Purification, partial characterization and molecular cloning of the novel antiviral protein RC28.

    abstract::An antiviral protein, RC28, with anti-herpesvirus activity was purified from a PBS extract of Rozites caperata (Cortinarious caperata) by acetone precipitation followed by gel filtration and ion exchange chromatography. The molecular weight of this protein was 28.251kDa as measured by MALDI-TOF mass spectrography. Our...


    pub_type: 杂志文章


    authors: Gong M,Piraino F,Yan N,Zhang J,Xia M,Ma J,Cheng J,Liu X

    更新日期:2009-04-01 00:00:00

  • Plantaricin A, a peptide pheromone produced by Lactobacillus plantarum, permeabilizes the cell membrane of both normal and cancerous lymphocytes and neuronal cells.

    abstract::Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...


    pub_type: 杂志文章


    authors: Sand SL,Oppegård C,Ohara S,Iijima T,Naderi S,Blomhoff HK,Nissen-Meyer J,Sand O

    更新日期:2010-07-01 00:00:00

  • Trp-Arg-Xaa tripeptides act as uncompetitive-type inhibitors of human dipeptidyl peptidase IV.

    abstract::Human dipeptidyl peptidase IV (hDPPIV, alternative name: CD26) inhibitors provide an effective strategy for the treatment of type 2 diabetes. Recently, our research group discovered a non substrate-mimic inhibitory dipeptide, Trp-Arg, by the systematic analysis of a dipeptide library. In the present study, a tripeptid...


    pub_type: 杂志文章


    authors: Lan VT,Ito K,Ito S,Kawarasaki Y

    更新日期:2014-04-01 00:00:00

  • Glucagon-like peptide-1 protects mesenteric endothelium from injury during inflammation.

    abstract::Glucagon-like peptide-1 (GLP-1) is a proglucagon-derived hormone with cellular protective actions. We hypothesized that GLP-1 would protect the endothelium from injury during inflammation. Our aims were to determine the: (1) effect of GLP-1 on basal microvascular permeability, (2) effect of GLP-1 on increased microvas...


    pub_type: 杂志文章


    authors: Dozier KC,Cureton EL,Kwan RO,Curran B,Sadjadi J,Victorino GP

    更新日期:2009-09-01 00:00:00

  • Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice.

    abstract::Obstructive jaundice (OJ) increases the risk of liver injury and sepsis, leading to increased mortality. Cholestatic liver injury is associated with a downregulation of hepcidin expression levels. In fact, hepcidin has an important antimicrobial effect, especially against Escherichia coli. It is unknown whether supple...


    pub_type: 杂志文章


    authors: Huang YH,Yang YL,Tiao MM,Kuo HC,Huang LT,Chuang JH

    更新日期:2012-06-01 00:00:00

  • Phosphoproteomic analysis of the effect of cyclo-[His-Pro] dipeptide on PC12 cells.

    abstract::The effects of dipeptide cyclo-[His-Pro] (CHP), known to participate in the appetite behavior and food intake control, have been investigated using PC12 cells in culture as model system. We found that only in the presence of experimental conditions that cause cellular stress the cyclic dipeptide affect cellular prolif...


    pub_type: 杂志文章


    authors: Minelli A,Bellezza I,Grottelli S,Pinnen F,Brunetti L,Vacca M

    更新日期:2006-01-01 00:00:00

  • Pigment-dispersing hormones: a novel family of neuropeptides from arthropods.

    abstract::This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...


    pub_type: 杂志文章,评审


    authors: Rao KR,Riehm JP

    更新日期:1988-01-01 00:00:00

  • Somatostatin in the brain of the turtle Testudo hermanni Gmelin. An immunohistochemical mapping study.

    abstract::An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...


    pub_type: 杂志文章


    authors: Weindl A,Triepel J,Kuchling G

    更新日期:1984-01-01 00:00:00

  • The ghrelin paradox in the control of equine chondrocyte function: The good and the bad.

    abstract::Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...


    pub_type: 杂志文章


    authors: Ceriotti S,Consiglio AL,Casati L,Cremonesi F,Sibilia V,Ferrucci F

    更新日期:2018-05-01 00:00:00

  • Molecular cloning, over expression, and activity studies of a peptidic HIV-1 protease inhibitor: designed synthetic gene to functional recombinant peptide.

    abstract::The aspartic protease inhibitor (ATBI) purified from a Bacillus sp. is a potent inhibitor of several proteases including recombinant HIV-1 protease, pepsin, and fungal aspartic protease. In this study, we report the cloning, and over expression of a synthetic gene coding for ATBI in Escherichia coli and establish a pu...


    pub_type: 杂志文章


    authors: Vathipadiekal V,Umasankar PK,Patole MS,Rao M

    更新日期:2010-01-01 00:00:00

  • The effect of bombesin-related peptides on the phagocytic function of mouse phagocytes in vitro.

    abstract::Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic functio...


    pub_type: 杂志文章


    authors: Jin GF,Guo YS,Smith ER,Houston CW

    更新日期:1990-03-01 00:00:00

  • Marked ion dependence of 125I-angiotensin I binding to atypical sites on Mycoplasma hyorhinis.

    abstract::125I-Ang I binding to atypical sites on Mycoplasma hyorhinis-contaminated IEC-18 cell membranes increased with increasing pH and [NaCl] (ED50 at 500 mM; maximal 13-fold increase at 2 M NaCl). Alkali metal chlorides and sodium halides increased binding with rank orders of Na+ < K+ < Rb+ < Cs+ = Li+ and F- < Cl- < Br < ...


    pub_type: 杂志文章


    authors: Smith RD

    更新日期:1999-01-01 00:00:00

  • Impaired angiogenesis in neuropeptide Y (NPY)-Y2 receptor knockout mice.

    abstract::Which of Y1-Y5 receptors (Rs) mediate NPY's angiogenic activity was studied using Y2R-null mice and R-specific antagonists. In Y2R-null mice, NPY-induced aortic sprouting and in vivo Matrigel capillary formation were decreased by 50%; Y1R-antagonist blocked the remaining response. NPY-induced sprouting was equally inh...


    pub_type: 杂志文章


    authors: Lee EW,Grant DS,Movafagh S,Zukowska Z

    更新日期:2003-01-01 00:00:00

  • Demonstration of substance P in aortic nerve afferent fibers by combined use of fluorescent retrograde neuronal labeling and immunocytochemistry.

    abstract::Combined use of the intraaxonal retrograde transport of the fluorescent marker 'true blue' with substance P (SP) immunocytochemistry has been used to trace the nodose ganglion projections of SP-containing neurons of the aortic depressor nerve. It has been found that (1) SP immunoreactive (SP-I) cell bodies are clearly...


    pub_type: 杂志文章


    authors: Helke CJ,Goldman W,Jacobowitz DM

    更新日期:1980-01-01 00:00:00