Abstract:
:We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitatively similar to those found for dynorphin A and alpha-neo-endorphin in earlier studies. The antiserum used was highly specific with only dynorphin-32 and dynorphin B-29, both of which contain the dynorphin B sequence, showing substantial cross-reactivity. Gel filtration of whole rat brain extracts in combination with HPLC analysis provide strong evidence for the existence of these latter two peptides in rat brain.
journal_name
Peptidesjournal_title
Peptidesauthors
Zhu YX,Höllt V,Loh Hdoi
10.1016/0196-9781(83)90083-9subject
Has Abstractpub_date
1983-11-01 00:00:00pages
871-4issue
6eissn
0196-9781issn
1873-5169pii
0196-9781(83)90083-9journal_volume
4pub_type
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