Immunoreactive peptides related to dynorphin B (= rimorphin) in the rat brain.

Abstract:

:We have developed a radioimmunoassay for synthetic dynorphin B, a novel opioid tridecapeptide, which shares a common precursor molecule with dynorphin1-17 (= dynorphin A) and the neo-endorphins. The levels of immunoreactivity towards this peptide in rat brain and pituitary show a pattern quantitatively and qualitatively similar to those found for dynorphin A and alpha-neo-endorphin in earlier studies. The antiserum used was highly specific with only dynorphin-32 and dynorphin B-29, both of which contain the dynorphin B sequence, showing substantial cross-reactivity. Gel filtration of whole rat brain extracts in combination with HPLC analysis provide strong evidence for the existence of these latter two peptides in rat brain.

journal_name

Peptides

journal_title

Peptides

authors

Zhu YX,Höllt V,Loh H

doi

10.1016/0196-9781(83)90083-9

subject

Has Abstract

pub_date

1983-11-01 00:00:00

pages

871-4

issue

6

eissn

0196-9781

issn

1873-5169

pii

0196-9781(83)90083-9

journal_volume

4

pub_type

杂志文章

相关文献

PEPTIDES文献大全
  • Oxyntomodulin and its C-terminal octapeptide inhibit liquid meal-stimulated acid secretion.

    abstract::Oxyntomodulin (OXM), a 37-amino acid glucagon-containing peptide produced mainly in intestine and endocrine pancreas, is present in rat plasma and inhibits pentagastrin-stimulated gastric acid secretion in both the anesthetized and the conscious rat. In order to investigate the modifications in acid and water secretio...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(86)90196-8

    authors: Jarrousse C,Niel H,Audousset-Puech MP,Martinez J,Bataille D

    更新日期:1986-01-01 00:00:00

  • Functional relations of crab molt-inhibiting hormone and neurohypophysial peptides.

    abstract::Biological and immunological relationships between molt-inhibiting hormone (MIH) activity in eyestalk ganglia extracts of the crab, Cancer antennarius Stimpson, and peptides of the vasopressin-oxytocin family were assessed. Lysine vasopressin (LVP), arginine vasopressin (AVP), vasotocin (VT), and oxytocin (OT) mimicke...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(85)90166-4

    authors: Mattson MP,Spaziani E

    更新日期:1985-07-01 00:00:00

  • Postoperative plasma copeptin levels independently predict delirium and cognitive dysfunction after coronary artery bypass graft surgery.

    abstract::Copeptin can reflect individual's stress state and are correlated with poor outcome of critical illness. The occurrence of postoperative delirium (POD) and cognitive dysfunction (POCD) is associated with worse outcome after coronary artery bypass graft (CABG) surgery. The present study aimed to investigate the ability...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2014.06.016

    authors: Dong S,Li CL,Liang WD,Chen MH,Bi YT,Li XW

    更新日期:2014-09-01 00:00:00

  • Immunohistochemical mapping of galanin-like immunoreactivity in the brain of the dogfish Scyliorhinus canicula.

    abstract::The distribution of galanin-like immunoreactivity in the brain of the dogfish Scyliorhinus canicula was investigated using the indirect immunofluorescence technique. In the telencephalon, positive cells and fibers were located in the mid-caudal part of the area superficialis basalis, the n. septi caudoventralis and in...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(91)90025-k

    authors: Vallarino M,Feuilloley M,Vandesande F,Vaudry H

    更新日期:1991-03-01 00:00:00

  • Isolation of Leu-Pro-Pro-Gly-Pro-Leu-Pro-Arg-Pro-NH2 (Antho-RPamide), an N-terminally protected, biologically active neuropeptide from sea anemones.

    abstract::Using a radioimmunoassay against the C-terminal sequence Arg-Pro-NH2 (RPamide), we have isolated the peptide Leu-Pro-Pro-Gly-Pro-Leu-Pro-Arg-Pro-NH2 (Antho-RPamide) from an extract of the sea anemone Anthopleura elegantissima. Antho-RPamide is located in neurons of sea anemones. Application of low concentrations of An...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(92)90040-a

    authors: Carstensen K,Rinehart KL,McFarlane ID,Grimmelikhuijzen CJ

    更新日期:1992-09-01 00:00:00

  • Chromatographic identification of Met- and Leu-enkephalin in the human fetal spinal cord.

    abstract::Using the indirect immunofluorescence method, enkephalin-like immunoreactivity was visualized on human fetus spinal cord sections (gestational age from 17 to 25 weeks). Immunolabeled varicose fibers and terminal-like structures were seen through the whole length fetal spinal cord principally in the dorsal gray, in the...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(88)90018-6

    authors: Rougeot C,Charnay Y,Dray F,Dubois PM

    更新日期:1988-01-01 00:00:00

  • Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls.

    abstract::To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...

    journal_title:Peptides

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0196-9781(95)00024-e

    authors: Hartmann A,Dietl T,Krumrey K,Vogl L,Dirlich G,Holsboer F,Heuser-Link M

    更新日期:1995-01-01 00:00:00

  • The first identified neuropeptide in the insect order Megaloptera: a novel member of the adipokinetic hormone family in the alderfly Sialis lutaria.

    abstract::This is the first report on the structural identity of a neuropeptide of the insect order Megaloptera. A peptide was isolated and sequenced from the retrocerebral corpora cardiaca glands of the alderfly, Sialis lutaria. The sequence of the peptide was deduced from the multiple MS(N) electrospray mass data as that of a...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2008.07.022

    authors: Gäde G,Simek P,Marco HG

    更新日期:2009-03-01 00:00:00

  • Pharmacological evidence for neurokinin receptors in murine neuroblastoma C1300 cells.

    abstract::We found that neurokinin A (NKA) and neurokinin B (NKB) induce an increase in the concentration of intracellular free Ca2+ ([Ca2+]i) in murine neuroblastoma C1300 cells (EC50: NKA 87 +/- 13 nM, NKB 97 +/- 15 nM). Substance P (SP) also caused a transient Ca2+ increase, although the potency of SP was much less than that...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(94)00166-9

    authors: Fukuhara S,Mukai H,Munekata E

    更新日期:1995-01-01 00:00:00

  • Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance.

    abstract::Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2010.07.012

    authors: Nichols R,Demers LA,Larsen BM,Robinson D,Converso K,Russell MW,Westfall MV

    更新日期:2010-11-01 00:00:00

  • RNAIII inhibiting peptide (RIP) inhibits agr-regulated toxin production.

    abstract::Staphylococcal enterotoxins (SEs) are emetic toxins that cause food poisoning. SEs also function as powerful pyrogenic toxin superantigens that stimulate non-specific T-cell proliferation. Together with the hemolysins, SEs have been largely implicated as virulence factors in multiple infection models. Recent biochemic...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/s0196-9781(01)00497-1

    authors: Vieira-da-Motta O,Ribeiro PD,Dias da Silva W,Medina-Acosta E

    更新日期:2001-10-01 00:00:00

  • Correlation between the expression of the histone H4 mRNA variant H4-v.1 and the levels of histone H4-(86-100) and H4-(89-102) (OGP) in various rat tissues and alveolar macrophages.

    abstract::We studied the expression of the osteogenic and antinociceptive C-terminal histone H4-related peptide fragments, H4-(89-102) (OGP) and H4-(86-100), respectively, within various rat tissues and isolated alveolar macrophages (AM) by radioimmunoassay (RIA). OGP was located mainly within the bone marrow, spleen, thymus, a...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2005.03.013

    authors: Poirier R,Lemaire I,Dumont M,Leduc N,Le HT,Lemaire S

    更新日期:2005-08-01 00:00:00

  • The effects of cysteamine and capsaicin on somatostatin and substance P in medullary nuclei.

    abstract::Administration of the thiol reagent, cysteamine, reduced the somatostatin content (70-80%) in each of the discrete medullary nuclei assayed without altering the substance P content of the same nuclei. In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(83)90016-5

    authors: Helke CJ,Selsky JH

    更新日期:1983-09-01 00:00:00

  • Parasitic peptides! The structure and function of neuropeptides in parasitic worms.

    abstract::Parasitic worms come from two very different phyla-Platyhelminthes (flatworms) and Nematoda (roundworms). Although both phyla possess nervous systems with highly developed peptidergic components, there are key differences in the structure and action of native neuropeptides in the two groups. For example, the most abun...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/s0196-9781(99)00093-5

    authors: Day TA,Maule AG

    更新日期:1999-01-01 00:00:00

  • Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats.

    abstract::Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2015.09.002

    authors: Sato A,Yokoyama I,Ebina K

    更新日期:2015-11-01 00:00:00

  • Purification, partial characterization and molecular cloning of the novel antiviral protein RC28.

    abstract::An antiviral protein, RC28, with anti-herpesvirus activity was purified from a PBS extract of Rozites caperata (Cortinarious caperata) by acetone precipitation followed by gel filtration and ion exchange chromatography. The molecular weight of this protein was 28.251kDa as measured by MALDI-TOF mass spectrography. Our...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2008.11.016

    authors: Gong M,Piraino F,Yan N,Zhang J,Xia M,Ma J,Cheng J,Liu X

    更新日期:2009-04-01 00:00:00

  • Kidney angiotensin II receptors and converting enzyme in neonatal and adult Wistar-Kyoto and spontaneously hypertensive rats.

    abstract::The aim of the present study was to correlate the development of the renin angiotensin system (RAS) in the kidney of the rat with the development of genetic hypertension. Immature (1-week-old) and adult (12-week-old) normotensive Wistar-Kyoto (WKY) and spontaneously hypertensive kidney rats (SHR) were used for quantif...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(94)00150-5

    authors: Correa FM,Viswanathan M,Ciuffo GM,Tsutsumi K,Saavedra JM

    更新日期:1995-01-01 00:00:00

  • Inhibition of rat uterine contractions by rat and human CGRP.

    abstract::Effects of rat and human calcitonin gene-related peptide (r alpha CGRP and h beta CGRP, respectively) upon uterine contractile force were investigated using uterine horns from nonpregnant rats, r alpha CGRP and h beta CGRP were equipotent (pD2 = 8.85-9.09) in inhibiting spontaneous and electrically evoked uterine cont...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(90)90006-q

    authors: Pennefather JN,Reynoldson NA,Handberg GM

    更新日期:1990-09-01 00:00:00

  • Cardiorenovascular effects of urotensin II and the relevance of the UT receptor.

    abstract::Urotensin II (U-II) is a vasoactive peptide with many potent effects in the cardiorenovascular system. U-II activates a G-protein-coupled receptor termed UT. UT and U-II are highly expressed in the cardiovascular and renal system. Patients with various cardiovascular diseases show high U-II plasma levels. It was demon...

    journal_title:Peptides

    pub_type: 杂志文章,评审

    doi:10.1016/j.peptides.2007.08.029

    authors: Tölle M,van der Giet M

    更新日期:2008-05-01 00:00:00

  • The effect of neuropeptide Y on brown-like adipocyte's differentiation and activation.

    abstract::Despite its wide distribution in the central nervous system, the presence of Neuropeptide Y (NPY) in peripheral tissues has been detected. White adipose tissue (WAT) is a new site of NPY synthesis and secretion. The development of brown-like adipocytes in WAT is controlled by hypothalamic NPY neurons through interacti...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2014.10.018

    authors: Wan Y,Xue R,Wang Y,Zhang Q,Huang S,Wu W,Ye H,Zhang Z,Li Y

    更新日期:2015-01-01 00:00:00

  • Phoenixin-14 injected intracerebroventricularly but not intraperitoneally stimulates food intake in rats.

    abstract::Phoenixin, a recently discovered 20-amino acid peptide was implicated in reproduction. However, the expression in food intake-regulatory nuclei such as the paraventricular nucleus, the arcuate nucleus and the nucleus of the solitary tract suggests an implication of phoenixin in food intake regulation. Therefore, we in...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2017.08.004

    authors: Schalla M,Prinz P,Friedrich T,Scharner S,Kobelt P,Goebel-Stengel M,Rose M,Stengel A

    更新日期:2017-10-01 00:00:00

  • Analogs of RGDVY and GRGD peptides inhibit Mycobacterium kansasii phagocytosis.

    abstract::Continuing our research on Mycobacteria kansasii phagocytosis inhibition, we have examined in that context three series of peptides derived from the RGDVY and GRGD sequences. It was found that the levels of the inhibitory activity depend on the amino acid composition as well as on the particular peptide sequence. Dist...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2003.07.002

    authors: Siemion IZ,Gawlowska M,Krajewski K,Strug I,Wieczorek Z

    更新日期:2003-08-01 00:00:00

  • Changes in urine levels of substance P, vasoactive intestinal peptide and calcitonin-gene-related peptide in patients with urinary tract infections.

    abstract::Urinary tract infections (UTI) are important health problems and predisposing causes of UTI are not entirely known. Neuro-immune interactions play an important role in human health and disease. Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as su...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2014.04.003

    authors: Altuntaş SÇ,Ipekçi T,Yakupoğlu G,Erin N

    更新日期:2014-06-01 00:00:00

  • Neuropeptide modulation of social and exploratory behaviors in laboratory rodents.

    abstract::Neuropeptide influences on exploratory and social behaviors were investigated, using a video-monitored computer-assisted automated animal behavior analysis system. Cholecystokinin decreased exploratory tendencies in the dose range 0.1-5.0 microgram/kg IP and 0.5-5.0 microgram/IVT, indicating a peripheral mechanism in ...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(81)90066-8

    authors: Crawley JN,Hays SE,O'Donohue TL,Paul SM,Goodwin FK

    更新日期:1981-01-01 00:00:00

  • Anti-inflammatory activity of alpha-MSH(11-13) analogs: influences of alteration in stereochemistry.

    abstract::D-Amino acid substitutions in the anti-inflammatory/antipyretic Ac-alpha-MSH(11-13)-NH2 tripeptide of Ac-alpha-MSH(1-13)-NH2 were made and the altered peptides were injected in mice treated with picryl chloride. Ear swelling, measured 3 and 6 h after application of the irritant, was reduced by IP injections of Ac-alph...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(91)90131-8

    authors: Hiltz ME,Catania A,Lipton JM

    更新日期:1991-07-01 00:00:00

  • Enhanced expression of neurotensin/neuromedin N mRNA and products of NT/NMN precursor processing in neonatal rats.

    abstract::Intestinal levels of immunoreactive neurotensin (iNT) and neuromedin N (iNMN), as well as mRNA for the NT/NMN precursor, were elevated during the suckling period in rats. While transient expression of NT/NMN was observed at 1-5 days of age in the proximal small intestine and colon, NT/NMN levels in the ileum increased...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(93)90161-9

    authors: Muraki K,Mitra SP,Dobner PR,Carraway RE

    更新日期:1993-11-01 00:00:00

  • Comparative in vitro effects of guinea pig VIP and common VIP on liver and lung membranes from guinea pig and rat and on human lymphoblastic SUP-T1 membranes.

    abstract::Guinea pig VIP differs from VIP of several mammals by its amino acids in positions 5, 9, 19 and 26. We tested a) its ability to occupy VIP receptors in liver and lung membranes of rat and guinea pig and in the human lymphoblastic SUP-T1 cell line and b) the ensuing adenylate cyclase stimulation. In liver and lung memb...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(91)90180-w

    authors: Cauvin A,Buscail L,Gourlet P,De Neef P,Robberecht P,Yanaihara N,Christophe J

    更新日期:1991-01-01 00:00:00

  • Screening of soy and milk protein hydrolysates for their ability to activate the CCK1 receptor.

    abstract::The cholecystokinin receptor-type 1 (CCK1R) is a G-protein coupled receptor localized in the animal gastrointestinal tract. Receptor activation by the natural peptide ligand CCK leads to a feeling of satiety. In this study, hydrolysates from soy and milk proteins were evaluated for their potential to activate the CCK1...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/j.peptides.2011.11.019

    authors: Staljanssens D,Van Camp J,Billiet A,De Meyer T,Al Shukor N,De Vos WH,Smagghe G

    更新日期:2012-03-01 00:00:00

  • Pharmacological characterization of angiotensin II binding sites in the canine pancreas.

    abstract::High affinity 125I-angiotensin II (Ang II) binding sites were characterized in the canine pancreas. Total binding increased with protein concentration and equilibrium was reached within 60-90 min at 22 degrees C. Specific binding was saturable and averaged 70% of total. Scatchard analysis of binding yielded a KD of 0....

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(92)90114-i

    authors: Chappell MC,Diz DI,Jacobsen DW

    更新日期:1992-03-01 00:00:00

  • Arginine vasotocin and renal function in the conscious dog.

    abstract::The effects of arginine vasotocin (AVT), 4-6 ng/kg, on renal function and plasma prolactin (PRL) were determined in conscious American foxhounds undergoing a water diuresis. Intravenous AVT produced an antidiuresis, kaliuresis and inconsistent natriuresis, independently of changes in GFR, blood pressure, heart rate an...

    journal_title:Peptides

    pub_type: 杂志文章

    doi:10.1016/0196-9781(82)90062-6

    authors: Gilmore JP,Wesley CR,Huffman L,Nemeh MN

    更新日期:1982-11-01 00:00:00