Abstract:
:Milk is the best, complete food important for the development and nourishment of a neonate. Except for nutrients, milk contains biologically active opioid peptides derived from beta-casein, named beta-casomorphins (BCMs), which can exert effects in the gastrointestinal tract as well as in the whole body of neonates. The content of beta-casomorphins in human milk during maturation phases has not been studied so far. The aim of this study was to determine the content of beta-casomorphin-5 and -7 in human milk in different phases of lactation. A significantly higher concentration of both beta-casomorphins was found in colostrum than in mature milk. The concentration of beta-casomorphin in milk collected in the second month of lactation was similar to the level obtained in the fourth month of lactation. The content of beta-casomorphins in human milk was observed with the period of lactation. The level of opioid peptides may depend on the function of these peptides in neonate's body and may be associated with the maturation process.
journal_name
Peptidesjournal_title
Peptidesauthors
Jarmołowska B,Sidor K,Iwan M,Bielikowicz K,Kaczmarski M,Kostyra E,Kostyra Hdoi
10.1016/j.peptides.2007.08.002subject
Has Abstractpub_date
2007-10-01 00:00:00pages
1982-6issue
10eissn
0196-9781issn
1873-5169pii
S0196-9781(07)00279-3journal_volume
28pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::Lysine-8-vasopressin (LVP) was injected into the lateral ventricle (ICV) or into the cisterna magna (c.m.) of ether-anesthetized rats. ICV injection of LVP decreased the blood pressure (BP), whereas c.m. administration increased it. The opposite effects of ICV versus c.m. administration of the peptide might be related...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90021-5
更新日期:1986-05-01 00:00:00
abstract::The heptadecapeptide, orphanin FQ or nociceptin (Phe-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln), originally isolated from rat brain has been identified as an endogenous ligand for the orphan opioid-like receptor. Although orphanin FQ shares some sequence and structural homology with kappa-opioid pept...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00037-5
更新日期:1997-01-01 00:00:00
abstract::We performed the first comprehensive peptidomic analysis of neurohormones from hemipteran insects by analyzing the neuropeptides of two major neurohemal organs, namely the corpora cardiaca and abdominal perisympathetic organs. For the experiments we selected four related species of polyphagous stinkbugs (Pentatomidae)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.08.034
更新日期:2008-02-01 00:00:00
abstract::HP-1 is the most abundant human representative of a recently discovered class of neutrophil cystine- and arginine-rich peptides. These peptides have many potentially regulatory activities expressed at nanomolar concentrations. To establish the levels of HP-1 that can accumulate in human lung tumors and nondiseased lun...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90152-s
更新日期:1992-01-01 00:00:00
abstract::The effect of caseinomacropeptide (CMP) (the [106-169] fragment of kappa-casein produced during digestion of milk protein), was studied in anesthetized rats using bile diversion for a pure pancreatic juice collection system. Intraduodenal administration of CMP induced a dose-related specific stimulation of pancreatic ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00307-7
更新日期:2000-10-01 00:00:00
abstract::C-type natriuretic peptide (CNP) stimulates endochondrial ossification by activating the transmembrane guanylyl cyclase, natriuretic peptide receptor-B (NPR-B). Recently, a spontaneous autosomal recessive mutation that causes severe dwarfism in mice was identified. The mutant, called long bone abnormality (lbab), cont...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.04.020
更新日期:2008-09-01 00:00:00
abstract::Effects of Met-enkephalin (Met-ENK) and opioid antagonists on H2O2 release by peritoneal macrophages from DA and AO rats were investigated. Met-ENK increased and decreased H2O2 production by macrophages of DA and AO rats, respectively. These effects were antagonized by low, but not high, concentrations of naloxone and...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)02003-f
更新日期:1995-01-01 00:00:00
abstract::Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90113-7
更新日期:1989-07-01 00:00:00
abstract:BACKGROUND:Visfatin is a novel adipokine and proinflammatory cytokine which is implicated in breast cancer progression. The exact proliferative and anti-apoptotic mechanisms of visfatin are still under debate. In this study, the effect of extracellular visfatin on proliferation and apoptosis of breast cancer cells were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.04.007
更新日期:2017-06-01 00:00:00
abstract::Legionella pneumophila, the causative agent of Legionnaires' disease, is a waterborne bacteria. It can multiply in man-made water systems and infect people who inhale contaminated droplets. We have previously reported a Staphylococcus warneri strain that display an anti-Legionella activity. In this work, we characteri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.01.017
更新日期:2008-06-01 00:00:00
abstract::The functional help provided by four cross-linked synthetic peptides from HIV-1 Gag structural proteins was investigated in the mouse model. These peptides, selected upon non-self-criteria, are not predicted as T epitopes by classical prediction methods such as the Rothbard consensus or the amphipathy rule. Priming mi...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90055-8
更新日期:1994-01-01 00:00:00
abstract::Endothelial neutral endopeptidase (EC 3.4.24.11, NEP) contributes to the inactivation of vasoactive and inflammatory peptides such as f-Met-Leu-Phe, substance P, atrial natriuretic peptide, and bradykinin. The aim of the present study was to investigate the cellular regulation of NEP expression in human endothelial ce...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00077-w
更新日期:1995-01-01 00:00:00
abstract::We tested the effects of intra-lateral septal infusions of neuropeptide Y (NPY) combined with systemic injections of topiramate in the DRL-72s paradigm and the elevated plus-maze test in male Wistar rats. Intra-lateral septal infusions of desipramine (5.0 microg/microl; P<0.05) or intra-lateral septal infusions of NPY...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.03.012
更新日期:2010-06-01 00:00:00
abstract::Neural input to distinct and separate populations of CRF-immunoreactive (ir) neurons in rat forebrain was investigated. The relationship of opiocortin and/or catecholamine fibers to different groups of CRF-containing neurons was elucidated using single and dual labeling immunocytochemical procedures. Antibodies to CRF...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90005-3
更新日期:1989-11-01 00:00:00
abstract::Opioid receptor binding properties of [3H]Tyr-D-Ala-Phe-Phe-NH2 (TAPP) were characterized in rat brain and Chinese hamster ovary (CHO) cells expressing the rat mu-receptor. In rat brain, [3H]TAPP labeled a single class of opioid sites with a dissociation constant (Kd) of 0.31 nM and maximal number of binding sites (Bm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00023-0
更新日期:1998-01-01 00:00:00
abstract::STKR is a neurokinin receptor derived from the stable fly, Stomoxys calcitrans. Insect tachykinin-related peptides, also referred to as "insectatachykinins", produce dose-dependent calcium and cyclic AMP responses in cultured Drosophila melanogaster Schneider 2 (S2) cells that were stably transfected with the cloned S...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.015
更新日期:2005-01-01 00:00:00
abstract::Human beta-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune system that serves as antimicrobial molecule. We determined the bactericidal activity of synthetic hBD-2 against nosocomial strains belonging to eight different bacterial species and exhibiting various antimicrobial resistance pheno...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.06.010
更新日期:2010-09-01 00:00:00
abstract::The distribution of the VIP containing structures was studied in the gut and in the paravertebral sympathetic ganglia of the quail and chick embryos by immunocytochemistry. In the gut, development of peptidergic nerves followed a craniocaudal gradient. Immunoreactive fibres were first visible in the oesophagus at day ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90206-7
更新日期:1984-03-01 00:00:00
abstract::The last decades have seen no significant progress in extending the survival of lung cancer patients and there is an urgent need to improve current therapies. The substance P (SP)/neurokinin-1 receptor (NK-1R) system plays an important role in the development of cancer: SP and NK-1R antagonists respectively induce cel...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.09.024
更新日期:2012-12-01 00:00:00
abstract::Histidyl-proline diketopiperazine (cyclo(His-Pro), a metabolite of the neuropeptide thyrotropin releasing hormone, has been shown to possess intrinsic biological activities. The binding of this peptide to various tissue particulate preparations was investigated. While the peptide showed no apparent binding to particul...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(83)90172-9
更新日期:1983-01-01 00:00:00
abstract::Peptides of the short neuropeptide F (sNPF) family have been shown to modulate feeding behavior in a wide variety of insect species. While these peptides stimulate feeding and food-searching behavior in Drosophila melanogaster and Apis mellifera, an opposite effect has recently been demonstrated in the desert locust, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.09.018
更新日期:2014-03-01 00:00:00
abstract::The present study involves the isolation and characterization of secretin-like immunoreactivity from the brains of pigs, rats and dogs. Secretin-like immunoreactivity was extracted with 0.1 N HCl and subjected to SP-Sephadex ion exchange chromatography and gel filtration on a Sephadex G-50 superfine column. The averag...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90039-7
更新日期:1985-03-01 00:00:00
abstract::To determine if insulin-like growth factor (IGF)-1 and -2, FSH, or leptin alter IGF-binding protein (IGFBP)-2, -3, -4, and -5 mRNA levels in bovine granulosa and (or) theca cells, granulosa and theca cells were collected from bovine ovarian follicles, plated for 48 h in 10% FCS and then treated for 24 h in serum-free ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.07.008
更新日期:2004-12-01 00:00:00
abstract::ACTH/MSH(4-10) (10 micrograms/kg/b.i.d.; IP), administered to pregnant Sprague-Dawley rats during gestational days (GD) 3 to 12, significantly increased the metabolic activity of extensor digitorum longus (EDL) muscle at postnatal day 14. ACTH/MSH peptide, administered from day of birth to postnatal day 13, had no eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90128-r
更新日期:1990-01-01 00:00:00
abstract::Marine snails of the genus Conus (∼500 species) are tropical predators that produce venoms for capturing prey, defense and competitive interactions. These venoms contain 50-200 different peptides ("conotoxins") that generally comprise 7-40 amino acid residues (including 0-5 disulfide bridges), and that frequently cont...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.01.018
更新日期:2014-03-01 00:00:00
abstract::The interindividual variability of the hydrolysis of leucine enkephalin, and of the formation of its hydrolysis by-products has been studied in human plasma. In agreement with known data, the data obtained indicate that Leu-enkephalin is degraded by several enzymes, belonging to three classes: aminopeptidases, dipepti...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00129-0
更新日期:1997-01-01 00:00:00
abstract::This review describes the role of modulation of intracellular adhesion molecule-1 (ICAM-1)/leukocyte function-associated antigen-1 (LFA-1) interaction in controlling autoimmune diseases or inducing immunotolerance. ICAM-1/LFA-1 interaction is essential for T-cell activation as well as for migration of T-cells to targe...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(03)00083-4
更新日期:2003-03-01 00:00:00
abstract::Using the indirect immunofluorescence method, enkephalin-like immunoreactivity was visualized on human fetus spinal cord sections (gestational age from 17 to 25 weeks). Immunolabeled varicose fibers and terminal-like structures were seen through the whole length fetal spinal cord principally in the dorsal gray, in the...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90018-6
更新日期:1988-01-01 00:00:00
abstract::In recent years our knowledge of the nervous control of the cerebral circulation has increased. The use of denervations and retrograde tracing in combination with immunohistochemical techniques has demonstrated that cerebral vessels are supplied with sympathetic, parasympathetic, and sensory nerve fibers and possibly ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00408-9
更新日期:2001-06-01 00:00:00
abstract::Substance P (SP) is known to be involved in processes related to learning and memory, fear, anxiety and stress. SP and NK1 receptors are localized in the hippocampus, a brain structure involved in learning and memory as well as emotional processes. As there is evidence for differential functions of the ventral (VH) an...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.02.014
更新日期:2008-07-01 00:00:00