Effect of Met-enkephalin and opioid antagonists on rat macrophages.

abstract：:A functional study has been performed to characterise the Y receptors responsible for NPY, PYY and PP-stimulated responses in mouse colonic mucosal preparations. Electrogenic ion secretion was stimulated with VIP following which NPY, PYY and PP analogues were, to varying degrees, inhibitory. PYY(3-36), hPP, Gln(23)hPP...

journal_title：Peptides

authors： Cox HM,Pollock EL,Tough IR,Herzog H

更新日期：2001-03-01 00:00:00

abstract：:Using Surface Plasmon Resonance (SPR) we investigated the interaction of seven neuropeptides with different characteristics and beta-amyloid (Abeta42) peptide, with membranes containing gangliosides. A wide range of affinities characterized the bindings (K(D) = 10(-3)- 10(-7) M), following the scheme: for GM1, Abeta42...

journal_title：Peptides

authors： Valdes-Gonzalez T,Inagawa J,Ido T

更新日期：2001-07-01 00:00:00

abstract：:The family of natriuretic peptides (NPs) discovered in mammalian tissues including cardiac atrium and brain consists of three members, namely, atrial, B- and C-type natriuretic peptides (ANP, BNP, CNP). Since the discovery, basic and clinical studies have been vigorously performed to explore the biological functions a...

journal_title：Peptides

authors： Kato J

更新日期：2020-10-01 00:00:00

abstract：:The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and functio...

journal_title：Peptides

authors： Omar B,Ahlkvist L,Yamada Y,Seino Y,Ahrén B

更新日期：2016-05-01 00:00:00

abstract：:Atrial natriuretic peptide (ANP) and endothelin (ET) are endogenous vasoactive factors that exert potent diuretic and natriuretic actions. We have previously shown that ANP and ET-3 act through an NO pathway to inhibit the sodium-glucose cotransporter (SGLT) in the intestine [Gonzalez Bosc LV, Elustondo PA, Ortiz MC, ...

journal_title：Peptides

authors： Majowicz MP,Gonzalez Bosc LV,Albertoni Borghese MF,Delgado MF,Ortiz MC,Sterin Speziale N,Vidal NA

更新日期：2003-12-01 00:00:00

abstract：:Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...

journal_title：Peptides

authors： Jia F,Zhang Y,Wang J,Peng J,Zhao P,Zhang L,Yao H,Ni J,Wang K

更新日期：2019-02-01 00:00:00

abstract：:The immunoregulatory role of methionine-enkephalin (Met-enk) is well studied in mammals, but has not been explored in ectotherms despite the fact that this peptide is highly conserved in vertebrates. The present study demonstrates the diverse effects of Met-enk depending on its concentration and specific function of s...

journal_title：Peptides

authors： Singh R,Rai U

更新日期：2009-06-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) is a hypothalamic peptide that plays a critical role in the regulation of food intake and energy metabolism. In this study, we investigated the potential role of dense hippocampal MCH innervation in the spatially oriented food-seeking component of feeding behavior. Rats were trained...

journal_title：Peptides

authors： Sita LV,Diniz GB,Canteras NS,Xavier GF,Bittencourt JC

更新日期：2016-02-01 00:00:00

abstract：:Plasmodium falciparum malaria parasite invasion of erythrocytes is an essential step in host infection and the proteins involved in such invasion are the main target in developing an antimalarial vaccine. Secretory organelle-derived proteins (micronemal AMA1 protein and the RON2, 4, and 5 rhoptry neck proteins) have b...

journal_title：Peptides

authors： Curtidor H,Patiño LC,Arévalo-Pinzón G,Vanegas M,Patarroyo ME,Patarroyo MA

更新日期：2014-03-01 00:00:00

abstract：:We tested the endogenous tripeptide TRH (thyrotropin releasing hormone) ability to bind to MC (melanocortin) receptor subtypes. We discovered that TRH binds to the human MCI receptor expressed in COS cells and to murine B16 melanoma cells with 5790+/-1010 nM and 6370+/-1260 nM Ki's, respectively. TRH did not bind to t...

journal_title：Peptides

authors： Schiöth HB,Prusis P,Muceniece R,Mutulis F,Mutule I,Wikberg JE

更新日期：1999-01-01 00:00:00

abstract：:While the circadian rhythm of pituitary adrenocorticotropin (ACTH) secretion has been well characterized, the ultradian rhythm has been less thoroughly investigated. To study the episodic nature of ACTH secretion, unrestrained, unanesthetized rats were bled continuously through indwelling jugular venous cannulae and b...

journal_title：Peptides

authors： Carnes M,Brownfield MS,Kalin NH,Lent S,Barksdale CM

更新日期：1986-03-01 00:00:00

abstract：:The location of the cells giving rise to the tachykinergic innervation of the rat arcuate nucleus was studied by combining immunohistochemistry and retrograde axonal transport of a protein-gold complex (WGA-ApoHRP-gold). Small volumes (20 nl) of this marker were injected into the arcuate nucleus of the rat. Twenty-fou...

journal_title：Peptides

authors： Magoul R,Onteniente B,Benjelloun W,Tramu G

更新日期：1993-03-01 00:00:00

abstract：:In present study, we aimed to identify angiotensin I-converting enzyme (ACE)-inhibitory peptides from a salt-free soy sauce (SFS), a newly developed antihypertensive seasoning obtained by Aspergillus oryzae fermentation of soybean in the absence of salt, which can be transported through caco-2 cell monolayers. Through...

journal_title：Peptides

authors： Zhu XL,Watanabe K,Shiraishi K,Ueki T,Noda Y,Matsui T,Matsumoto K

更新日期：2008-03-01 00:00:00

abstract：:Subpopulations of dopamine (DA) neurons in the ventral mesencephalon have been reported to contain cholecystokinin (CCK) and neurotensin (NT), giving rise to DA, DA/NT, NT/CCK and DA/CCK/NT projections. More precisely, colocalized DA/CCK neurons project mainly to the caudal part of the medial nucleus accumbens, wherea...

journal_title：Peptides

authors： Heidbreder C,Gewiss M,De Mot B,Mertens I,De Witte P

更新日期：1992-05-01 00:00:00

abstract：:Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date. Although circulating levels of U-II are altered in lower species (e.g., fish) upon exposure to hypo-osmotic stress, little is known about the actions of this cycl...

journal_title：Peptides

authors： Disa J,Floyd LE,Edwards RM,Douglas SA,Aiyar NV

更新日期：2006-06-01 00:00:00

abstract：:CRF injected into the third cerebral ventricle (0.5-2.5 micrograms) caused dose-related reductions in fever induced in rabbits by IV administration of leukocytic pyrogen. Control injections of CRF when the same animals were afebrile did not alter normal body temperature. Intravenous injections of 5 and 20 micrograms C...

journal_title：Peptides

authors： Bernardini GL,Richards DB,Lipton JM

更新日期：1984-01-01 00:00:00

abstract：:Peptidomic analysis of norepinephrine-stimulated skin secretions of the South-East Asian frog Hylarana erythraea (formerly Rana erythraea partim) has led to the identification of multiple peptides with antimicrobial activity. Structural characterization of the peptides demonstrated that they belong to the brevinin-1 (...

journal_title：Peptides

authors： Al-Ghaferi N,Kolodziejek J,Nowotny N,Coquet L,Jouenne T,Leprince J,Vaudry H,King JD,Conlon JM

更新日期：2010-04-01 00:00:00

abstract：:The neuropeptide oxytocin (OXT) contributes to the regulation of diverse cognitive and physiological functions including nociception. Indeed, OXT has been reported to be analgesic when administered directly into the brain, the spinal cord, or systemically. Although many authors have reported the analgesic effects of O...

journal_title：Peptides

authors： Russo R,D'Agostino G,Mattace Raso G,Avagliano C,Cristiano C,Meli R,Calignano A

更新日期：2012-11-01 00:00:00

abstract：:The involvement of spinal opioid receptors and spinal monoaminergic systems, in the antinociceptive effect of intrathecal (IT) salmon calcitonin, has been evaluated by means of the hot plate test, in the rat. Intrathecal pretreatment with 40 micrograms MR 1452 and 40 micrograms ICI 154,129, purported selective antagon...

journal_title：Peptides

authors： Candeletti S,Romualdi P,Spadaro C,Spampinato S,Ferri S

更新日期：1985-01-01 00:00:00

abstract：:Host-defense peptides secreted by epithelial cells exhibit cytotoxic and immunoregulatory effects in order to protect the organism against invading microorganisms. Antimicrobial peptides derived from frog skin display both immunostimulatory and immunosuppressive actions as demonstrated by in vitro cytokine production ...

journal_title：Peptides

authors： Pantic JM,Radosavljevic GD,Jovanovic IP,Arsenijevic NN,Conlon JM,Lukic ML

更新日期：2015-09-01 00:00:00

abstract：:Peptides spanning the range of human parathyroid hormone-related protein (PTHrP) have been shown to bind heat shock protein-70 expressed on the surface of cancer cells with cytoprotective consequences in vitro. The present study focused on identification of intracellular proteins that interact with the carboxy-termina...

journal_title：Peptides

authors： Grzesiak JJ,Burton DW,Deftos LJ,Bouvet M

更新日期：2006-07-01 00:00:00

abstract：:We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...

journal_title：Peptides

authors： Park HJ,Salem M,Semlali A,Leung KP,Rouabhia M

更新日期：2017-07-01 00:00:00

abstract：:Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. ...

journal_title：Peptides

authors： Bernardes CP,Santos NAG,Sisti FM,Ferreira RS,Santos-Filho NA,Cintra ACO,Cilli EM,Sampaio SV,Santos AC

更新日期：2018-06-01 00:00:00

abstract：:Ghrelin is a 28 amino acid peptide, primarily produced by the oxyntic mucosa X/A like neuroendocrine cells in the stomach. It is also found in the small intestine, hypothalamus, pituitary gland, pancreas, heart, adipose tissue, and immune system. In gastrointestinal neuroendocrine tumors (NETs) ghrelin release has bee...

journal_title：Peptides

authors： Vu JP,Wang HS,Germano PM,Pisegna JR

更新日期：2011-11-01 00:00:00

abstract：:Acute and chronic effects of gamma-butyrolactone-gamma-carbonyl-histidyl-prolinamide (DN-1417) were investigated on motor activity, dopamine (DA) metabolites and DA receptors in various brain regions of rats. The motor activity, as measured with Automex recorder, was enhanced after a single injection with DN-1417 (20 ...

journal_title：Peptides

authors： Nakahara T,Matsumoto T,Hirano M,Uchimura H,Yokoo H,Nakamura K,Ishibashi K,Hirano H

更新日期：1985-11-01 00:00:00

abstract：:Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), an endogenous mammalian antiopioid peptide, has been shown by other laboratories to attenuate the acute antinociceptive effects of morphine, the development of morphine tolerance, and naloxone-induced withdrawal in morphine-dependent rats. The present study determined the ef...

journal_title：Peptides

authors： Rothman RB,Brady LS,Xu H,Long JB

更新日期：1993-11-01 00:00:00

abstract：:Degradation of Boc CCK7 (Boc Tyr1 (SO3H)-Met2-Gly3-Trp4-Met5-Asp6-Phe7-NH2), a fully active analog of CCK8, by purified rabbit kidney neutral metalloendopeptidase (enkephalinase) was studied as a basis for the rational design of potent peptidases-resistant analogs of cholecystokinin. Characterization of the metabolite...

journal_title：Peptides

authors： Durieux C,Charpentier B,Fellion E,Gacel G,Pelaprat D,Roques BP

更新日期：1985-05-01 00:00:00

abstract：:VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...

journal_title：Peptides

authors： Ruellan C,Scemama JL,Clerc P,Fagot-Revurat P,Clemente F,Ribet A

更新日期：1986-01-01 00:00:00

abstract：:The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...

journal_title：Peptides

authors： Varndell IM,Tapia FJ,Probert L,Buchan AM,Gu J,De Mey J,Bloom SR,Polak JM

更新日期：1982-05-01 00:00:00

abstract：:The specific binding of 125I-labeled vasoactive intestinal peptide (VIP) to brain membranes from the forebrain and hindbrain regions of 2 to 37-day postnatal rats was measured. In both regions of the brain, VIP binding was low but detectable two days after birth and rose markedly between postnatal days 7 and 17. This ...

journal_title：Peptides

authors： Roth BL,Beinfeld MC

更新日期：1985-01-01 00:00:00