Abstract:
:Neurotensin has been demonstrated to be analgesic in rodents. This study used intrathecal injection of neurotensin in unanesthetized mice to evaluate the effect of the peptide at the spinal level on unconditioned behavior. Intrathecal administration of neurotensin produced dose-related inhibition of locomotor activity and of the response elicited by subcutaneous hypertonic saline. The effects of the peptide in the tail flick assay were variable and it produced no inhibition of the behavioral response to intrathecal substance P. The results indicate that neurotensin antinociception at the spinal level does not result from locomotor impairment, may be somewhat selective for chemically induced pain, and may be mediated by a presynaptic action on primary afferent fibers.
journal_name
Peptidesjournal_title
Peptidesauthors
Hylden JL,Wilcox GLdoi
10.1016/0196-9781(83)90057-8subject
Has Abstractpub_date
1983-07-01 00:00:00pages
517-20issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(83)90057-8journal_volume
4pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The effect of melanin-concentrating hormone (MCH) on the release of alpha-melanocyte stimulating hormone (alpha-MSH) from the tilapia pituitary gland was studied in vitro. In a superfusion set up, 10 nM to 1 microM synthetic salmon MCH caused a concentration-dependent inhibition of alpha-MSH release from tilapia neuro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00063-p
更新日期:1995-01-01 00:00:00
abstract::VIP and secretin control the secretory function of the normal pancreas. We analysed their regulatory functions in a human pancreatic cancer cell line: Capan-1. Saturation binding experiments with 125I-VIP showed the existence of one class of binding sites of very high affinity: KD 6.4 +/- 3.0 X 10(-11) M and a low Bma...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90200-7
更新日期:1986-01-01 00:00:00
abstract::Phe-Leu-Phe-Gln-Pro-Gln-Arg-Phe-NH2 (NPFF), an endogenous mammalian antiopioid peptide, has been shown by other laboratories to attenuate the acute antinociceptive effects of morphine, the development of morphine tolerance, and naloxone-induced withdrawal in morphine-dependent rats. The present study determined the ef...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90187-l
更新日期:1993-11-01 00:00:00
abstract::Chronic administration of neuroleptics has been shown to affect the endogenous levels, mRNA, posttranslational processing, and metabolism of neuropeptides in specific regions of rat brain. Neutral endopeptidase 24.11 (NEP) is known to metabolize a variety of neuropeptide substrates, including the enkephalins and neuro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(93)90080-z
更新日期:1993-09-01 00:00:00
abstract::Marine snails of the genus Conus (∼500 species) are tropical predators that produce venoms for capturing prey, defense and competitive interactions. These venoms contain 50-200 different peptides ("conotoxins") that generally comprise 7-40 amino acid residues (including 0-5 disulfide bridges), and that frequently cont...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2014.01.018
更新日期:2014-03-01 00:00:00
abstract::The present study purifies two T. serrulatus non-disulfide-bridged peptides (NDBPs), named venom peptides 7.2 (RLRSKG) and 8 (KIWRS) and details their synthesis and biological activity, comparing to the synthetic venom peptide 7.1 (RLRSKGKK), previously identified. The synthetic replicate peptides were subjected to a ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.05.008
更新日期:2016-08-01 00:00:00
abstract::Urotensin-II (U-II), a ligand for the G-protein-coupled receptor UT, has been characterized as the most potent mammalian vasoconstrictor identified to date. Although circulating levels of U-II are altered in lower species (e.g., fish) upon exposure to hypo-osmotic stress, little is known about the actions of this cycl...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2005.10.004
更新日期:2006-06-01 00:00:00
abstract::Adrenomedullin (AM) is highly expressed in various cancer cell lines, suggesting a possible association with cancer growth. In the present study, we examined the expression and/or concentration of AM, its related peptide, adrenomedullin2/intermedin (AM2/IMD) and their receptors in human colorectal cancer and the surro...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.07.012
更新日期:2011-09-01 00:00:00
abstract::Bombesin is a tetradecapeptide heterogenously distributed in the mammalian brain. Bombesin (45 micrograms) given intracisternally (IC) to unanesthetized rats increased the accumulation of dihydroxyphenylalanine (DOPA) in striatum, olfactory tubercles and hypothalamus after DOPA-decarboxylase inhibition, thus indicatin...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90081-0
更新日期:1984-05-01 00:00:00
abstract::Rats with dorsomedial hypothalamic lesions (DMN-L) or sham operations were injected IP with saline or the satiety peptide cholecystokinin (CCK) at 3.0 and 6.0 micrograms/kg at the onset of the dark phase. Food consumption was then measured 15, 30 and 60 min later. Compared to saline baseline intake, CCK suppressed fee...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90085-8
更新日期:1984-05-01 00:00:00
abstract::Angiotensin II (Ang II) is an oligopeptide of the renin-angiotensin system, and Ang II-induced vascular smooth muscle cell (VSMC) proliferation is an important pathophysiological process involved in atherosclerosis; however, the underlying mechanism remains unclear. Orai1 and Stim1 are the main components of store-ope...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170386
更新日期:2020-11-01 00:00:00
abstract::Radioautographic determinations of 125I-[Tyr0,D-Trp8]somatostatin-14 (125I-SRIF) binding sites were performed on frozen serial sections of the locus coeruleus (LC) of control rats and of rats subjected to either bilateral microinjections of 6 hydroxydopamine (6-OHDA) into the LC or unilateral microinjection into the a...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90104-d
更新日期:1990-01-01 00:00:00
abstract::Hypocretin-1 (hcrt-1) and hypocretin-2 (hcrt-2) are two recently discovered hypothalamic neuropeptides. In the present study, using double immunofluorescent techniques, the co-localization of hcrt-1 and hcrt-2 was examined in neuronal soma and fibers/terminals located, respectively, in the cat hypothalamus and brainst...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00084-0
更新日期:2002-08-01 00:00:00
abstract::An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90268-7
更新日期:1984-01-01 00:00:00
abstract::In order to study a possible direct action of LH-RH analogs on the pituitary lactotrophs, we investigated the effect of long-term in vivo pretreatment with D-Trp-6-LH-RH on in vitro secretion of PRL and luteinizing hormone (LH) by the pituitary glands from male and female rats. In vivo pretreatment with D-Trp-6-LH-RH ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90333-x
更新日期:1985-09-01 00:00:00
abstract::By immunohistochemistry it was found that PHI- and VIP-like immunoreactivity (-IR) occurred in the same autonomic neurons in the upper respiratory tract, tongue and salivary glands with associated ganglia in rat, guinea-pig, cat, pig and man. VIP- and PHI-like immunoreactivity was also found in similar locations in th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90090-1
更新日期:1984-05-01 00:00:00
abstract::To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and...
journal_title:Peptides
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0196-9781(95)00024-e
更新日期:1995-01-01 00:00:00
abstract::The opioid peptides, [3H]DAGO and [3H]DPDPE, bound to rat and guinea pig brain homogenates with a high, nanomolar affinity and to a high density of mu and delta receptors, respectively. [3H]DAGO binding to mu receptors was competitively inhibited by unlabelled opioids with the following rank order of potency: DAGO gre...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90135-6
更新日期:1989-05-01 00:00:00
abstract::Animal behavioral and neurochemical studies implicate dopaminergic systems in the neurological sequelae induced by estrogen. In the present study, we demonstrated for the first time that MIF-1, a neuropeptide unrelated to classical dopamine agonists, when given prior to, concurrently with, and after 17 beta-estradiol,...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90127-6
更新日期:1987-11-01 00:00:00
abstract::Naltrexone, an opiate antagonist, was administered to young obese (ob/ob) and lean mice for five weeks. Animals had continuous access to food and received 10 mg/kg SC twice daily with equivalent volumes of saline given to controls. The effects on body weight, and pituitary and plasma levels of beta-endorphin-like mate...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90008-x
更新日期:1980-01-01 00:00:00
abstract::We have examined the distributions of ACTH, CCK and enkephalin immunoreactive nerves in the rat central nervous system and compared the pattern obtained with that of opiate receptors. In addition, a radioreceptor assay has been employed for studying the possible functional interactions between these peptides and opiat...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(81)90050-4
更新日期:1981-01-01 00:00:00
abstract::Binding of [125I]PACAP-38 to rat liver membranes was investigated. It was rapid at 37 degrees C, reversible, and saturable, and it was time, concentration, and temperature dependent. Scatchard plots showed that [125I]PACAP-38 bound to single noninteracting site(s), and [125I]VIP bound to high- and low-affinity binding...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)90206-2
更新日期:1994-01-01 00:00:00
abstract::Obestatin is purported to be a peptide hormone encoded in preproghrelin. We studied the metabolic effects of continuous infusion of obestatin via subcutaneously implanted osmotic mini-pumps. Administration of up to 500nmol/kg body weight/day obestatin did not change 24h cumulative food intake or body weight in rats. S...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.03.023
更新日期:2008-08-01 00:00:00
abstract::Endothelial neutral endopeptidase (EC 3.4.24.11, NEP) contributes to the inactivation of vasoactive and inflammatory peptides such as f-Met-Leu-Phe, substance P, atrial natriuretic peptide, and bradykinin. The aim of the present study was to investigate the cellular regulation of NEP expression in human endothelial ce...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(95)00077-w
更新日期:1995-01-01 00:00:00
abstract::We have previously reported that hypoxia activates corticotrophin-releasing hormone (CRH) and the expression of its type-1 receptor (CRHR1) and induces disorders of the brain-endocrine-immune network. p53 is activated by hypoxia and involved in tumorigenesis and apoptosis. Whether CRHR1 regulates p53 transactivation t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.023
更新日期:2013-06-01 00:00:00
abstract::Atrial dipeptidyl carboxyhydrolase readily converts one atrial natriuretic peptide, atriopeptin II (Ser103-Arg125 peptide), to another, atriopeptin I (Ser103-Ser123 peptide), by selective removal of the C-terminal dipeptide, Phe-Arg. The atrial peptides possess natriuretic, diuretic, smooth muscle relaxant, and cardio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(89)90077-6
更新日期:1989-01-01 00:00:00
abstract::Intracerebroventricular (ICV) and subcutaneous (SC) injections of sauvagine powerfully inhibited gastric acid secretion stimulated by gastric distension and by 2-deoxy-D-glucose, but not by histamine in pylorus-ligated rats. Naloxone failed to antagonize the antisecretory effects of SC and ICV sauvagine. Intravenous i...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90131-3
更新日期:1988-07-01 00:00:00
abstract::The neuroendocrine and behavioral effects of Tyr-D-Ala-Gly-Phe-D-Nle-Arg-Phe (DADN), a more stable derivative of the endogenous opiate Met-enkephalin related peptide Met(5)-enkephalin-Arg(6)-Phe(7) were investigated in mice. The behavioral experiments consisted of monitoring the horizontal (square crossing) and vertic...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.05.029
更新日期:2011-08-01 00:00:00
abstract::We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90081-f
更新日期:1990-03-01 00:00:00
abstract::The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and functio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2016.03.012
更新日期:2016-05-01 00:00:00