Abstract:
:The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we have investigated the effects of UII and URP on cell proliferation and free cytosolic Ca2+ concentration ([Ca2+]i) in CHO-K1 cells stably expressing the porcine somatostatin receptor subtypes sst2 and sst5. Results show that both UII and URP induce stimulation of cell proliferation mediated by sst2 receptors and UII provokes inhibition of cell proliferation mediated by sst5 receptors. UII and URP also provoked an increase of [Ca2+]i in both sst2- and sst5-transfected cells. Together, our present data demonstrate that UII and URP directly activate sst2 and sst5 and thus mimic the effect of somatostatin on its cognate receptors.
journal_name
Peptidesjournal_title
Peptidesauthors
Malagon MM,Molina M,Gahete MD,Duran-Prado M,Martinez-Fuentes AJ,Alcain FJ,Tonon MC,Leprince J,Vaudry H,Castaño JP,Vazquez-Martinez Rdoi
10.1016/j.peptides.2007.12.015subject
Has Abstractpub_date
2008-05-01 00:00:00pages
711-20issue
5eissn
0196-9781issn
1873-5169pii
S0196-9781(08)00004-1journal_volume
29pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::The use of protein A- and IgG-conjugated colloidal gold staining methods for the immuno-localisation of peptide hormones and neurotransmitters at light- and electron microscope level are described and discussed. Bright-field and dark-ground illumination modes have been used to visualise the gold-labelled antigenic sit...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(82)90086-9
更新日期:1982-05-01 00:00:00
abstract::Rats were injected IP with a 0.1 mg/kg dose of MIF-I, naloxone, dynorphin, [D-Phe4]-Met-enkephalin, [D-Ala2, F5Phe4]-Met-enkephalin-NH2, or the diluent vehicle, placed in their home cages for ten minutes, and then given ad lib access to either 20% sucrose, 10% sucrose, water, 0.01% quinine, or 0.02% quinine in a repea...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(80)90014-5
更新日期:1980-01-01 00:00:00
abstract::The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(99)00122-9
更新日期:1999-01-01 00:00:00
abstract::The distribution of urotensin I (UI) and corticotropin-releasing factor (CRF) immunoreactive (IR) structures was studied in the central nervous system (CNS) of the white sucker using the peroxidase-antiperoxidase immunocytochemical procedure. The close sequence homology between both peptides resulted in a high degree ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(86)90065-3
更新日期:1986-01-01 00:00:00
abstract::Antimicrobial peptides produced by multicellular organisms protect against pathogenic microorganisms, whereas such peptides produced by bacteria provide an ecological advantage over competitors. Certain antimicrobial peptides of metazoan origin are also toxic to eukaryotic cells, with preference for a variety of cance...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.04.010
更新日期:2010-07-01 00:00:00
abstract::Angiotensin (Ang)--a peptide that is part of the renin-angiotensin system-induces vasoconstriction and a subsequent increase in blood pressure; Ang peptides, especially AngII, can also act as potent pro-inflammatory mediators. Platelet-activating factor (PAF) is a potent phospholipid mediator that is implicated in man...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2015.09.002
更新日期:2015-11-01 00:00:00
abstract::The study was undertaken to investigate the oxidation and reduction of cholecystokinin (CCK) both as pure standards and as endogenous porcine peptides. Furthermore an attempt was made to prevent oxidation of the endogenous porcine peptides in the extraction procedure. CCK-8 and CCK-33 standards were always oxidized in...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90069-5
更新日期:1985-01-01 00:00:00
abstract::We tested the effects of intra-lateral septal infusions of neuropeptide Y (NPY) combined with systemic injections of topiramate in the DRL-72s paradigm and the elevated plus-maze test in male Wistar rats. Intra-lateral septal infusions of desipramine (5.0 microg/microl; P<0.05) or intra-lateral septal infusions of NPY...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.03.012
更新日期:2010-06-01 00:00:00
abstract::Bradykinin-potentiating peptides (BPPs) are an important group of toxins present in Lachesis muta rhombeata venom. They act directly at renin-angiotensin-aldosterone system, through the inhibition of angiotensin-converting enzyme (ACE). This action may contribute to the hypotensive shock observed during the envenoming...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.015
更新日期:2018-04-01 00:00:00
abstract::The influence of peripheral somatostatin immunoneutralization on intravenous (i.v.) and intracerebroventricular (ICV) bombesin-induced inhibition of gastric acid secretion (GAS) was investigated with the somatostatin monoclonal antibody, CURE.S6, in rats. The somatostatin antibody, injected i.v. in conscious rats with...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(94)00152-v
更新日期:1995-01-01 00:00:00
abstract::We have developed a semi-intact preparation-consisting of an isolated oviduct with abdominal ganglia VII and VIII intact and attached-with which to characterize the effects on oviduct contraction, of peptides that are bath applied to CNS tissues. The work presented here offers a qualitative analysis of the central eff...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00173-0
更新日期:2002-11-01 00:00:00
abstract::An immunohistochemical mapping study in the brain and upper spinal cord of the turtle Testudo hermanni Gmelin revealed a wide distribution of somatostatin perikarya and fibres. Within the telencephalon, somatostatin perikarya are present in the anterior olfactory nucleus, in the medial, dorsomedial and dorsal cortex, ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(84)90268-7
更新日期:1984-01-01 00:00:00
abstract::This study aimed to examine the effects of CPB on salusin-α, salusin-β and apelin-36 bioactive peptides in people who are planned to undergo coronary artery bypass graft (CABG) operation due to coronary artery disease and to explore whether these peptides are produced in human aortic, saphenous and arterial tissues. T...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.027
更新日期:2012-10-01 00:00:00
abstract::The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90117-9
更新日期:1988-07-01 00:00:00
abstract::Recently we have demonstrated that replacing His(6) by constrained amino acids(2) in the well-known antagonist SHU-9119 resulted in potent and selective antagonist ligands especially at the hMC3R and hMC5 receptors. With the aim to further explore position 6 in the sequence of SHU-9119 and MT-II, we have designed, syn...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.02.012
更新日期:2007-06-01 00:00:00
abstract::This study evaluated the physiological importance of Angiotensin-(1-7) receptor Mas on reflex control of circulation. Experiments were performed in male Mas-knockout (Mas-KO) and Wild Type (WT) conscious mice (12-20 wk of age). Baroreceptor reflex was evaluated by the bradycardic response induced by phenylephrine (0.2...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.06.030
更新日期:2010-10-01 00:00:00
abstract::The conformation of insulin in the crystalline state has been known for more than 30 years but there remains uncertainty regarding the biologically active conformation and the structural features that constitute the receptor-binding domain. The primary structure of insulin has been determined for at least 100 vertebra...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(01)00423-5
更新日期:2001-07-01 00:00:00
abstract::During a stress response, various neuropeptides are secreted in a spatiotemporally coordinated way in the brain. For a precise understanding of peptide functions in a stress response, it is important to investigate when and where they are released, how they diffuse, and how they are broken down in the brain. In the pa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2020.170456
更新日期:2020-11-24 00:00:00
abstract::We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.05.003
更新日期:2017-07-01 00:00:00
abstract::Insect flight requires rapid mobilization of energy reserves during flight, which is mediated and regulated by hormonal control via adipokinetic hormones. The structure of the G-protein receptors to which these hormones bind, are crucial in understanding many of the physiological processes in which they play a central...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.08.017
更新日期:2011-03-01 00:00:00
abstract::Hypothalamic orexin neurons project to many brain areas, including hindbrain structures such as the nucleus of the solitary tract (NTS) and area postrema (AP), where orexin 1 receptors (OX1Rs) are expressed. Hindbrain administration of orexin-A increases feeding and meal size, and blockade of hindbrain OX1Rs with the ...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2020.170351
更新日期:2020-11-01 00:00:00
abstract::We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90081-f
更新日期:1990-03-01 00:00:00
abstract::This work showed the effect of pheromone plantaricin A (PlnA) on the proliferation and migration of the human keratinocytes NCTC 2544. PlnA was chemically synthesized and used as pure peptide or biologically synthesized during co-cultivation of Lactobacillus plantarum DC400 and Lactobacillus sanfranciscensis DPPMA174....
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2011.07.004
更新日期:2011-09-01 00:00:00
abstract::The conformational properties of the competitive angiotensin II antagonist sarmesin [Sar-Arg-Val-Tyr(Me)-His-Pro-Phe] and its heptapeptide analogue [des1]sarmesin in dimethylsulphoxide-d6 were investigated by nuclear Overhauser effect (NOE) enhancement studies. Assignment of all backbone and side-chain protons was pos...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90094-l
更新日期:1990-03-01 00:00:00
abstract::The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2004.02.019
更新日期:2004-04-01 00:00:00
abstract::The double-stranded RNA dependent protein kinase (PKR) is a negative regulator of cell proliferation and thus itself a target for modulation. We show that a cell-permeable peptide (PRI), containing a conserved double-stranded RNA binding motif found in PKR, inhibits activation of the kinase and activity to phosphoryla...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(00)00297-7
更新日期:2000-10-01 00:00:00
abstract::The influence of central vs. peripheral administration of specific type A and type B CCK receptor antagonists (L364,718 and L365,260, respectively) on colonic motor hyperactivity induced by feeding and CCK8 was investigated in dogs with strain-gauge transducers implanted on the proximal and transverse colon. Intraveno...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90095-7
更新日期:1991-05-01 00:00:00
abstract::Milk is one of the main source of biologically-active peptides that may function as regulatory substances called food hormones. After passing the gut-blood barrier, the μ-opioid receptor agonist and antagonist peptides may become the new factors influencing various functions of the human organism. The aim of the condu...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.12.003
更新日期:2011-04-01 00:00:00
abstract::We investigated the effect of surgical castration of male rats on the binding of [Tyr(125I)10]VIP to receptors on the anterior pituitary gland, superior mesenteric artery, brain, liver, and prostate gland. In anterior pituitary membranes the maximum number of VIP binding sites was increased whereas binding affinity wa...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90146-v
更新日期:1990-11-01 00:00:00
abstract::This report summarizes recent work on the chemistry and structure-activity relationships of crustacean chromatophorotropic pigment-dispersing hormones (PDHs) and the identification of structurally related peptides from insects. So far, the primary structures of crustacean alpha-PDH and beta-PDH and of a pigment-disper...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/0196-9781(88)90239-2
更新日期:1988-01-01 00:00:00