Abstract：
:Many mammalian brain-gut peptides are known to be represented in invertebrate nervous systems; we have now examined the possibility that an invertebrate neuropeptide occurs in vertebrates. Antisera were raised in rabbits to the molluscan neuropeptide. Phe-Met-Arg-Phe-NH2 (FMRFamide). The antiserum used for radioimmunoassay and immunocytochemistry is highly specific for the C-terminus of the tetrapeptide. In radioimmunoassays of tissue extracts of brain, gut and pancreas of various vertebrates (chicken, frog, dog, rat) concentrations of immunoreactive material up to about 200 pmol/g have been recorded. The immunoreactive material in chicken pancreas behaves on gel filtration and ion exchange chromatography as a molecule that is larger and less basic peptide that FMRFamide. Immunocytochemical studies have demonstrated an endocrine cell origin for FMRFamide-like material in chicken pancreas, and in dog ileum. In brain, FMRFamide can be localised to nerve cell bodies (frog) and nerve fibres (frog and rat). Synthetic FMRFamide has been shown to have excitatory actions on brain stem neurons in the rat. It is suggested that neurons in the rat central nervous system have receptors for FMRFamide that normally bind endogenous material with FMRFamide immunoreactivity.
journal_name
Peptidesjournal_title
Peptidesauthors
Dockray GJ,Vaillant C,Williams RG,Gayton RJ,Osborne NNdoi
10.1016/0196-9781(81)90005-xsubject
Has Abstractpub_date
1981-01-01 00:00:00pages
25-30eissn
0196-9781issn
1873-5169pii
0196-9781(81)90005-Xjournal_volume
2 Suppl 2pub_type
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