Abstract：
:The distribution of neurokinin B (NKB) was determined by immunocytochemistry with antisera directed toward its amino terminus. Immunoreactive perikarya were detected in the main and accessory olfactory bulbs, cortical regions, the olfactory tubercle, the bed nucleus of the stria terminalis, the diagonal band of Broca, the nucleus accumbens, the septum, the neostriatum, several hypothalamic nuclei, the superior colliculus, the central gray, the substantia nigra, the medullary reticular formation, and the external cuneate nucleus. The distribution of NKB-containing perikarya revealed by immunocytochemistry was similar to the distribution of protachykinin B-containing cells previously visualized by in situ hybridization. Immunoreactive nerve fibers and terminals were detected in all major subdivisions of the brain. The levels of NKB measured by radioimmunoassay were highest in the hypothalamus. The distribution of NKB in the rat brain was similar to the distribution of substance P; however, there were several regions where the two distributions were clearly different.
journal_name
Peptidesjournal_title
Peptidesauthors
Merchenthaler I,Maderdrut JL,O'Harte F,Conlon JMdoi
10.1016/0196-9781(92)90192-6subject
Has Abstractpub_date
1992-07-01 00:00:00pages
815-29issue
4eissn
0196-9781issn
1873-5169pii
0196-9781(92)90192-6journal_volume
13pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Vasoactive intestinal peptide (VIP) is a potent anti-inflammatory agent. In addition to the deactivation of macrophages, dendritic cells, and microglia, VIP shifts the Th1/Th2 balance, promoting the preferential differentiation and survival of Th2 cells, to the detriment of the proinflammatory Th1 effectors. Several m...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.03.015
更新日期：2007-09-01 00:00:00
abstract：:The objective of this study was to investigate absorption enhancing approaches for systemic delivery of methionine enkephalin via the nose. Absorption promotion of methionine enkephalin in the presence of protease inhibitors (bestatin, puromycin) and absorption enhancers (glycocholate, dimethyl-beta-cyclodextrin) were...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.02.019
更新日期：2004-04-01 00:00:00
abstract：:WH1fungin, a surfactin cyclopeptide from Bacillus amyloliquefaciens WH1, is firstly reported as a novel immunoadjuvant, which can markedly enhance the immune response when given in mixture with antigens. After intramuscular or subcutaneous immunization, WH1fungin can help to induce both of durable humoral and cellular...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.08.021
更新日期：2012-11-01 00:00:00
abstract：:Dendroaspis natriuretic peptide (DNP) is one of four members of the natriuretic peptide family sharing functional and structural properties. The purpose of the present study was to elucidate the physiological role of DNP on renal functions and its cellular mechanism in the rabbit kidney. DNP (5 μg/kg/min) infused intr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.12.006
更新日期：2012-01-01 00:00:00
abstract：:Antimicrobial peptides (AMP) have been widely described in several organisms from different kingdoms. We recently designed and evaluated a synthetic version of an AMP isolated and characterized from Argopecten purpuratus hemocytes. This study describes the generation of a chimaeric gene encoding for Ap-S, the use of t...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.07.007
更新日期：2011-09-01 00:00:00
abstract：:This report reviews the hypothesis that peptides play a role in appetite modulation, stressing that the available evidence is predominantly pharmacological and thus caution needs to be taken in assigning physiological significance at this time. Two peptide systems have been postulated--a peripheral satiety system, typ...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/0196-9781(85)90153-6
更新日期：1985-01-01 00:00:00
abstract：:Self-administration of ethanol and food share many common features and Richter hypothesized that an increase in ethanol consumption would decrease feeding to balance the excess calories contained in the ethanol. Previously, we have shown that individual alcohol consumption correlates with neurotransmitter gene express...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.09.011
更新日期：2007-12-01 00:00:00
abstract：:Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.10.018
更新日期：2007-02-01 00:00:00
abstract：:Double-labeling immunofluorescence of guinea pig tracheobronchial lymph nodes revealed complete coincidence of SP and CGRP immunoreactivities in perivascular nerves and axons of the medullary lymphatic tissue. Additional dynorphin A or cholecystokinin immunoreactivity was seen only in some of the medullary fibers. Ult...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(90)90103-c
更新日期：1990-01-01 00:00:00
abstract：:Neurotensin-like immunoreactive neuronal perikarya, fibers and terminals in in the rat hypothalamus were investigated by light and electron microscopic immunocytochemistry. Distributional density and pattern of these elements were clarified. Fine structure of immunoreactive neuronal perikarya with respect to developme...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(84)90270-5
更新日期：1984-01-01 00:00:00
abstract：:The gastrin-releasing peptide receptor (GRPR) has been implicated in the modulation of emotionally-motivated memory. In the present study, we investigated the role of the GRPR on non-emotional, non-associative memory, and anxiety. Adult male Wistar rats were given a systemic injection of the GRPR antagonist [D-Tpi6, L...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.06.006
更新日期：2005-12-01 00:00:00
abstract：:A novel protein expressed by entero-endocrine cells of the mouse stomach was named prepromotilin Related Peptide (ppMTLRP) since it shares sequence similarities with the prepromotilin (Tomasetto et al.). The mouse ppMTLRP was found identical to the rat precursor of ghrelin (ppghrelin), an endogenous ligand specific fo...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00557-5
更新日期：2001-12-01 00:00:00
abstract：:Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced fro...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2012.09.032
更新日期：2013-03-01 00:00:00
abstract：:Opioid receptor analyses of deltorphin A (H-Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2) analogues indicated the following: (a) increased negativity differentially affected affinities (Ki) and selectivity (Ki mu/Ki delta); (b) shifted sequence heptapeptides, [Asp5,Leu6,Met-NH2(7)] and [Asp4,His5,Leu6,Met-NH2(7)], reversed selec...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90006-3
更新日期：1993-01-01 00:00:00
abstract：:There is growing evidence of the antimicrobial properties of histones and histone-derived peptides; however, most of them are specific to lysine (Lys)-rich histones (H1, H2A, and H2B). In the present study, we focused on arginine (Arg)-rich histones (H3 and H4) and investigated their antimicrobial properties in compar...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.09.005
更新日期：2011-10-01 00:00:00
abstract：:This study determined the long-term influence of prenatal nicotine exposure (PN) on blood pressure and vascular functions in the aged offspring rats. PN did not affect body weight and plasma adrenocorticotropic hormone level; however, it significantly reduced plasma angiotensin I and angiotensin II in both sexes. Syst...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.02.019
更新日期：2013-06-01 00:00:00
abstract：:Caudodorsal cell hormone-I (CDCH-I), a 36 amino acid peptide synthesized by the caudodorsal cells (CDCs), is one of the major neuropeptides present in the cerebral ganglia of the freshwater snail, Lymnaea stagnalis. This peptide induces ovulation and egg-mass formation, and, in addition, acts on neuronal circuits invo...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90099-o
更新日期：1992-03-01 00:00:00
abstract：:The immunoregulatory role of methionine-enkephalin (Met-enk) is well studied in mammals, but has not been explored in ectotherms despite the fact that this peptide is highly conserved in vertebrates. The present study demonstrates the diverse effects of Met-enk depending on its concentration and specific function of s...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.02.016
更新日期：2009-06-01 00:00:00
abstract：:This work showed the effect of pheromone plantaricin A (PlnA) on the proliferation and migration of the human keratinocytes NCTC 2544. PlnA was chemically synthesized and used as pure peptide or biologically synthesized during co-cultivation of Lactobacillus plantarum DC400 and Lactobacillus sanfranciscensis DPPMA174....
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.07.004
更新日期：2011-09-01 00:00:00
abstract：:An antifungal protein was isolated from the mushroom Tricholoma giganteum var. golden blessings. The protocol included ion exchange chromatography on DEAE-cellulose, affinity chromatography on Affi-gel blue gel, ion exchange chromatography on CM-cellulose, and gel filtration by fast protein liquid chromatography on Su...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2004.11.009
更新日期：2005-04-01 00:00:00
abstract：:Native peptides can be regarded as surrogate markers for protease activity in biological samples. Analysis of peptides by peptidomics allows to monitor protease activity in vivo and to describe the influence of protease inhibition. To elucidate the potential of peptides as markers for in vivo protease inhibition we an...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.08.016
更新日期：2008-12-01 00:00:00
abstract：:We employed a proteomic approach to search for peptides that have a physiological role in labor. Cervicovaginal secretions were collected at term from women in labor and women at term not in labor. Samples were spotted onto weak cation exchange chips (WCX-2) and analyzed using Surface-Enhanced Laser Desorption Ionizat...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.03.015
更新日期：2006-07-01 00:00:00
abstract：:The release of peptides immunoreactive for a synthetic peptide (V-9-M) contained in the amino-terminal of pro-CCK was examined. The potassium-evoked release of V-9-M immunoreactive peptides from rat cerebral cortical slices in vitro was calcium dependent. Cholecystokinin-secreting rat medullary thyroid carcinoma cells...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90011-q
更新日期：1992-11-01 00:00:00
abstract：:Increasing evidence suggests a role for ghrelin in the control of articular inflammatory diseases like osteoarthritis (OA). In the present study we examined the ability of ghrelin to counteract LPS-induced necrosis and apoptosis of chondrocytes and the involvement of GH secretagogue receptor (GHS-R)1a in the protectiv...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.03.003
更新日期：2018-05-01 00:00:00
abstract：:Imidazole-related dipeptides, such as carnosine and anserine, occur widely in skeletal muscles of jawed vertebrates. All of the known enzymes that catalyze the hydrolysis of these dipeptides belong to the M20A metallopeptidase subfamily; two secretory enzymes, serum carnosinase (EC 3.4.13.20) and anserinase (EC 3.4.13...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.01.008
更新日期：2011-04-01 00:00:00
abstract：:Antimicrobial peptides (AMPs) are believed to be a promising class of antimicrobial agents against bacteria and fungi. To promote the clinical use of AMPs, their antimicrobial activity and susceptibility to protease degradation should be further improved. The antimicrobial peptide Jelleine-I was originally isolated fr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.11.006
更新日期：2019-02-01 00:00:00
abstract：:Antisauvagine-30 (aSVG) is the only high-affinity antagonist for the corticotropin-releasing factor (CRF) type 2 (CRF(2)) receptor. A structure-activity relationship study was performed to pinpoint residues conferring aSVG's selectivity. The aSVG-analogues being N-terminally extended by one or two residues or containi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(02)00139-0
更新日期：2002-10-01 00:00:00
abstract：:Previous physiological studies have suggested central roles of brain natriuretic peptide (BNP). However, little information is available about the localization of BNP in the brain. In this study, we determined cDNA sequence encoding the entire coding region of prepro-BNP of Japanese and cynomologus monkeys, and then e...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.01.001
更新日期：2006-07-01 00:00:00
abstract：:We are interested in the presence and function in insects of neuropeptides related to the vertebrate tachykinins. Hence, we have used antisera raised against the tachykinins substance P and kassinin, and against the insect neuropeptide leucokinin I, for localization studies and immunochemical analysis of related pepti...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(93)90094-w
更新日期：1993-07-01 00:00:00
abstract：:The definitive function of pancreatic polypeptide in mammalian physiology remains unknown. The identification of specific PP target tissues should be helpful to further investigations into the possible regulatory actions of this peptide. An in vivo radioreceptor assay was used in the rat to locate potential binding si...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00372-0
更新日期：1998-01-01 00:00:00
