Substance P-immunoreactive nerve fibers in tracheobronchial lymph nodes of the guinea pig: origin, ultrastructure and coexistence with other peptides.

abstract：:Cholecystokinin (CCK) and met-enkephalin (MEK) related peptides have been shown to alter feeding behavior subsequent to their injection into the peripheral circulation or directly into the brains of several species. To evaluate the potential role of endogenous brain pools of these peptides in feeding, groups of sheep ...

journal_title：Peptides

authors： Scallet AC,Della-Fera MA,Baile CA

更新日期：1985-09-01 00:00:00

abstract：:Several considerations led us to directly measure, using radioimmunoassay, the levels of dynorphin-A(1-8), cholecystokinin-8, and Met5-enkephalin-Arg6-Gly7-Leu8 (MERGL) in lysed-P2 membranes, membranes incubated 60 min at 25 degrees C in 50 mM TRIS-HCl at pH 7.4, and membranes preincubated 60 min at 25 degrees C in TR...

journal_title：Peptides

authors： Rothman RB,Danks JA,Iadarola MJ

更新日期：1987-07-01 00:00:00

abstract：:Rhoptries are specialized secretory organelles found in all members of the genus Plasmodium whose proteins have been considered as promising vaccine candidates due to their involvement in cell invasion and the formation of the parasitophorous vacuole (PV). The Plasmodium falciparum Pf34 protein was recently identified...

journal_title：Peptides

authors： Arévalo-Pinzón G,Curtidor H,Vanegas M,Vizcaíno C,Patarroyo MA,Patarroyo ME

更新日期：2010-11-01 00:00:00

abstract：:We evaluated behavior and cognitive performance in a line of transgenic mice that overexpress the rat gene for vasopressin. Open field testing revealed greatest habituation in homozygous mice. Passive avoidance performance indicated equal learning and memory ability of transgenic compared to normal mice. Drinking beha...

journal_title：Peptides

authors： Miller M,Haroutunian V,Wiltshire-Clement M

更新日期：1995-01-01 00:00:00

abstract：:Recent pharmacological data strongly support the hypothesis of delta receptor subtypes as mediators of both supraspinal and spinal antinociception (delta 1 and delta 2 receptors). In vitro ligand binding data, which are fully supportive of the in vivo data, are still lacking. A previous study indicated that [3H][D-Ala...

journal_title：Peptides

authors： Xu H,Partilla JS,de Costa BR,Rice KC,Rothman RB

更新日期：1992-11-01 00:00:00

abstract：:Glucagon is a peptide hormone secreted from the pancreatic alpha cells in response to hypoglycemia but in some patients with type 2 diabetes a paradoxical hypersecretion results from the intake of glucose. In rodent, antagonizing the actions of glucagon have been shown to be effective for lowering blood glucose levels...

journal_title：Peptides

authors： Wewer Albrechtsen NJ

更新日期：2018-02-01 00:00:00

abstract：:To investigate the contribution of the N-terminal sequence of h-EGF to its biological activity and the formation of three intramolecular disulfide bonds by oxidative refolding via air oxidation, five derivatives of h-EGF with a single N-terminal amino acid deletion were synthesized by solid-phase synthesis. The homoge...

journal_title：Peptides

authors： Shin SY,Shimizu M,Ohtaki T,Munekata E

更新日期：1995-01-01 00:00:00

abstract：:Trefoil factors family 2 (TFF2), also known as spasmolytic polypeptide, is primarily expressed in the mucus neck cells of gastrointestinal tracts. It has been proposed that TFF2 plays an important physiological role in protection, repair, and healing of gastrointestinal mucosa. To investigate the cis-acting regulatory...

journal_title：Peptides

authors： Chi AL,Lim S,Wang TC

更新日期：2004-05-01 00:00:00

abstract：:The present study was designed to detect the change of substance P (SP) in firearm wounds and its relationship with wound healing. Twenty two rabbits were randomly divided into two groups, one with firearm wounds created by steel balls shooting rabbits' thighs and another with stab wounds created by knife. The experim...

journal_title：Peptides

authors： Xinan L,Suguang L,Liangchao Z,Lei C

更新日期：1998-01-01 00:00:00

abstract：:Immunohistochemical studies were conducted on rat brainstem using a specific polyclonal antiserum against the COOH-terminal (25-37) of human amylin. Amylin-immunoreactive cell bodies were observed in the vestibular, cochlear, trapezoid, and inner cerebellar nuclei and in the mesencephalic nucleus of trigeminal nerve. ...

journal_title：Peptides

authors： D'Este L,Casini A,Wimalawansa SJ,Renda TG

更新日期：2000-11-01 00:00:00

abstract：:Ad lib and intraoral intake tests can separate the effects of drugs on the appetitive and consummatory phases of ingestive behavior. Central angiotensin II increases ad lib intake from water bottles, but its effect on intraoral intake has not been examined. Rats with both lateral intracerebroventricular (i.c.v.) cannu...

journal_title：Peptides

authors： Houpt TA,Corp ES,Berlin R

更新日期：1998-01-01 00:00:00

abstract：:In the conscious dog migrating and nonmigrating colonic motor complexes (CMC) were recorded by means of chronically implanted strain gauge force transducers. Intravenous injection of a synthetic enkephalin analogue immediately induced a premature CMC at all three recording sites of the colon. Naloxone inhibited the en...

journal_title：Peptides

authors： Bickel M,Belz U

更新日期：1988-05-01 00:00:00

abstract：:Ureases (EC 3.5.1.5) are metalloenzymes that hydrolyze urea into ammonia and CO(2). These proteins have insecticidal and fungicidal effects not related to their enzymatic activity. The insecticidal activity of urease is mostly dependent on the release of internal peptides after hydrolysis by insect digestive cathepsin...

journal_title：Peptides

authors： Postal M,Martinelli AH,Becker-Ritt AB,Ligabue-Braun R,Demartini DR,Ribeiro SF,Pasquali G,Gomes VM,Carlini CR

更新日期：2012-11-01 00:00:00

abstract：:One novel Kunitz BPTI-like peptide designated as BBPTI-1, with chymotrypsin inhibitory activity was identified from the venom of Burmese Daboia russelii siamensis. It was purified by three steps of chromatography including gel filtration, cation exchange and reversed phase. A partial N-terminal sequence of BBPTI-1, HD...

journal_title：Peptides

authors： Guo CT,McClean S,Shaw C,Rao PF,Ye MY,Bjourson AJ

更新日期：2013-05-01 00:00:00

abstract：:Marine snails of the genus Conus (∼500 species) are tropical predators that produce venoms for capturing prey, defense and competitive interactions. These venoms contain 50-200 different peptides ("conotoxins") that generally comprise 7-40 amino acid residues (including 0-5 disulfide bridges), and that frequently cont...

journal_title：Peptides

authors： Zamora-Bustillos R,Rivera-Reyes R,Aguilar MB,Michel-Morfín E,Landa-Jaime V,Falcón A,Heimer EP

更新日期：2014-03-01 00:00:00

abstract：:Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy ex...

journal_title：Peptides

authors： Pissios P

更新日期：2009-11-01 00:00:00

abstract：:We employed a proteomic approach to search for peptides that have a physiological role in labor. Cervicovaginal secretions were collected at term from women in labor and women at term not in labor. Samples were spotted onto weak cation exchange chips (WCX-2) and analyzed using Surface-Enhanced Laser Desorption Ionizat...

journal_title：Peptides

authors： Brown AG,Leite RS,Engler AJ,Discher DE,Strauss JF 3rd

更新日期：2006-07-01 00:00:00

abstract：:A novel conotoxin, pc16a, was isolated from the venom of Conus pictus. This is the first peptide characterized from this South-African cone snail and it has only 11 amino acid residues, SCSCKRNFLCC*, with the rare cysteine framework XVI and a monoisotopic mass of 1257.6Da. Two peptides were synthesized with two possib...

journal_title：Peptides

authors： Van Der Haegen A,Peigneur S,Dyubankova N,Möller C,Marí F,Diego-García E,Naudé R,Lescrinier E,Herdewijn P,Tytgat J

更新日期：2012-03-01 00:00:00

abstract：:Antibodies directed against amyloid beta protein (AssP) have been suggested to be effective in the treatment of Alzheimer's disease (AD). Here, we used in vivo and in vitro models to test some of the mechanisms by which antibodies may produce their effects. We found that the blood-to-brain uptake of murine AssP1-42 wa...

journal_title：Peptides

authors： Banks WA,Pagliari P,Nakaoke R,Morley JE

更新日期：2005-02-01 00:00:00

abstract：:The experiments reported here investigate the conditionability, using taste aversion conditioning, of the antagonistic effects of alpha-MSH on the thermoregulatory changes associated with injection of bacterial endotoxin lipopolysaccharide (LPS) in rats. Animals were administered LPS and then given alpha-MSH, as an un...

journal_title：Peptides

authors： Bull DF,Husband AJ,Munro KI,Exton MS,Pfister HP,King MG

更新日期：1994-01-01 00:00:00

abstract：:The conformation of insulin in the crystalline state has been known for more than 30 years but there remains uncertainty regarding the biologically active conformation and the structural features that constitute the receptor-binding domain. The primary structure of insulin has been determined for at least 100 vertebra...

journal_title：Peptides

authors： Conlon JM

更新日期：2001-07-01 00:00:00

abstract：:We examined the effect of adjuvant arthritis on the content of immunoreactive calcitonin gene-related peptide (iCGRP) in the dorsal root ganglia at L4-L6 levels and the spinal cord at a lumbar level in rats. Arthritis was induced by inoculating adjuvant into both hind-paws twice at a 10 day interval. In the arthritic ...

journal_title：Peptides

authors： Kuraishi Y,Nanayama T,Ohno H,Fujii N,Otaka A,Yajima H,Satoh M

更新日期：1989-03-01 00:00:00

abstract：:Enzymatic cleavage of endogenous peptides is a commonly used principle to initiate, modulate and terminate action for instance among cytokines and peptide hormones. The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and the related hormone glucagon-like pepti...

journal_title：Peptides

authors： Gabe MBN,van der Velden WJC,Smit FX,Gasbjerg LS,Rosenkilde MM

更新日期：2020-03-01 00:00:00

abstract：:Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroven...

journal_title：Peptides

authors： Yang S,Kawamura Y,Yoshikawa M

更新日期：2003-02-01 00:00:00

abstract：:Amphibians exhibit various, characteristic adaptations related to their "incomplete" shift from the aquatic to the terrestrial habitat. In particular, the integument was subject to a number of specialized modifications during the evolution of these animals. In this review, we place special emphasis on endogenous host-...

journal_title：Peptides

authors： König E,Bininda-Emonds OR,Shaw C

更新日期：2015-01-01 00:00:00

abstract：:Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying ...

journal_title：Peptides

authors： Boccia L,Gamakharia S,Coester B,Whiting L,Lutz TA,Le Foll C

更新日期：2020-10-01 00:00:00

abstract：:Using a one-bottle taste aversion conditioning paradigm, sulfated cholecystokinin(26-33) (CCK-8) has again been shown to induce taste aversion conditioning in rats. Even though the effective doses of CCK-8 are relatively high, they do not induce as strong an aversion as has been demonstrated with LiCl. This pharmacody...

journal_title：Peptides

authors： Ervin GN,Mosher JT,Birkemo LS,Johnson MF

更新日期：1995-01-01 00:00:00

abstract：:In this study, antimicrobial peptide S-thanatin (Ts) was chemically synthesized and linked to keyhole limpet hemocyanin (KLH) and bovine serum albumin (BSA) by carbodiimide reagent. Rabbits were immunized with Ts-KLH and polyclonal antibody against Ts was purified by fractional precipitation of ammonium sulfate, coupl...

journal_title：Peptides

authors： Wu G,Wang S,Wang X,Li X,Deng X,Shen Z,Xi T

更新日期：2011-07-01 00:00:00

abstract：:Humanin (HN) and HN-derivatives are a family of peptides first reported in the last decade with potent in vitro and in vivo neuroprotective activity, which is mediated through a not completely elucidated mechanism. Recently, our group has evaluated the effect of various HN-derivatives on the 3-quinuclidinyl benzilate ...

journal_title：Peptides

authors： Evangelou A,Zikos C,Benaki D,Pelecanou M,Bouziotis P,Papadopoulos M,Borovickova L,Vesela I,Elbert T,Kunesová G,Pirmettis I,Paravatou-Petsotas M,Slaninová J,Livaniou E

更新日期：2009-12-01 00:00:00

abstract：:Human beta-defensin 2 (hBD-2) is a 41-amino acid cationic peptide of the innate immune system that serves as antimicrobial molecule. We determined the bactericidal activity of synthetic hBD-2 against nosocomial strains belonging to eight different bacterial species and exhibiting various antimicrobial resistance pheno...

journal_title：Peptides

authors： Routsias JG,Karagounis P,Parvulesku G,Legakis NJ,Tsakris A

更新日期：2010-09-01 00:00:00