Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation.

Abstract:

:Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroventricular administration, and at 100mg/kg after oral administration. These doses are smaller than the optimal doses for an analgesic effect. The memory enhancing effect of rubiscolin-6 was blocked by pretreatment with the delta antagonist naltrindole, suggesting the involvement of the delta opioid receptor.

journal_name

Peptides

journal_title

Peptides

authors

Yang S,Kawamura Y,Yoshikawa M

doi

10.1016/s0196-9781(03)00044-5

subject

Has Abstract

pub_date

2003-02-01 00:00:00

pages

325-8

issue

2

eissn

0196-9781

issn

1873-5169

pii

S0196978103000445

journal_volume

24

pub_type

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