Abstract:
:Rubiscolin-6 (YPLDLF) is a delta selective opioid peptide isolated from the enzymatic digests of ribulose bisphosphate carboxylase/oxygenase (Rubisco) from spinach leaves. In a step-through type passive avoidance test in ddY mice, rubiscolin-6 enhanced memory consolidation at doses of 3nmol/mouse after intracerebroventricular administration, and at 100mg/kg after oral administration. These doses are smaller than the optimal doses for an analgesic effect. The memory enhancing effect of rubiscolin-6 was blocked by pretreatment with the delta antagonist naltrindole, suggesting the involvement of the delta opioid receptor.
journal_name
Peptidesjournal_title
Peptidesauthors
Yang S,Kawamura Y,Yoshikawa Mdoi
10.1016/s0196-9781(03)00044-5subject
Has Abstractpub_date
2003-02-01 00:00:00pages
325-8issue
2eissn
0196-9781issn
1873-5169pii
S0196978103000445journal_volume
24pub_type
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