Abstract：
:Catestatin (CST) is an endogenous neuropeptide with multiple cardiovascular activities. The study is to investigate circulating CST levels in heart failure (HF) patients and to evaluate the role of CST as a biomarker for HF. Plasma CST concentrations were measured by enzyme-linked immunosorbent assay in 228 HF patients and 172 controls. Plasma CST gradually increased in patients from NYHA class I to class IV. No significant differences in CST were found among NYHA I, NYHA II patients and controls. Plasma CST in NYHA III and IV patients was higher compared to other groups. Plasma CST levels in HF patients after treatment were similar to admission, but still higher than controls. In a subgroup analysis among the patients with NYHA class III or IV, patients with ischemic etiology had significantly higher CST. Plasma CST levels were similar between patients with preserved and reduced ejection fraction. Multivariable analysis showed that NYHA classes, the etiology of HF (ischemic or not) and estimated glomerular filtration rate independently predicted plasma LogCST levels (P<0.05). The area under ROC for CST and BNP in moderate to severe HF diagnosis was 0.626 and 0.831, respectively, combining CST and BNP did not improve the accuracy.
journal_name
Peptidesjournal_title
Peptidesauthors
Liu L,Ding W,Li R,Ye X,Zhao J,Jiang J,Meng L,Wang J,Chu S,Han X,Peng Fdoi
10.1016/j.peptides.2013.05.003subject
Has Abstractpub_date
2013-08-01 00:00:00pages
20-5eissn
0196-9781issn
1873-5169pii
S0196-9781(13)00194-0journal_volume
46pub_type
杂志文章相关文献
PEPTIDES文献大全abstract：:Ad lib and intraoral intake tests can separate the effects of drugs on the appetitive and consummatory phases of ingestive behavior. Central angiotensin II increases ad lib intake from water bottles, but its effect on intraoral intake has not been examined. Rats with both lateral intracerebroventricular (i.c.v.) cannu...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00269-6
更新日期：1998-01-01 00:00:00
abstract：:Peptides influence cardiac dysfunction; however, peptidergic modulation of contractile performance remains relatively uncharacterized. We identified a novel human peptide that modulates mammalian contractile performance. Members of the FMRFamide-related peptide (FaRP) family contain a C-terminal RFamide but structural...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.07.012
更新日期：2010-11-01 00:00:00
abstract：:Structurally unique, synthetic prion peptides provide the basis of a simple assay to serve as both a detection and signal amplification system that distinguishes the normal prion protein, PrPC, from the misfolded prion protein, PrPSc, that is associated with the occurrence of transmissible spongiform encephalopathies ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2005.03.006
更新日期：2005-11-01 00:00:00
abstract：:This study sought to determine the serum levels of chemerin in gastric cancer patients and healthy subjects and to investigate the biological effect of chemerin on gastric cancer cells. Serum chemerin level of 36 gastric cancer patients and 40 healthy subjects was measured by enzyme-linked immunosorbent assay. AGS and...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.10.009
更新日期：2014-01-01 00:00:00
abstract：:Phylloseptins are antimicrobial peptides of 19-20 residues which are found in the skin secretions of the Phyllomedusa frogs that inhabit the tropical forests of South and Central Americas. The peptide sequences of PS-1, -2, and -3 carry an amidated C-terminus and they exhibit 74% sequence homology with major variation...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2008.06.022
更新日期：2008-10-01 00:00:00
abstract：BACKGROUND:Since short bowel syndrome (SBS) patients face life-threatening conditions, the development of therapeutic strategies to induce intestinal adaptation has been investigated. Ghrelin, a ligand of growth hormone (GH) secretagogue-receptor that stimulates the release of GH and insulin like growth factor-1 (IGF-1...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.06.009
更新日期：2018-08-01 00:00:00
abstract：:Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2018.01.007
更新日期：2018-03-01 00:00:00
abstract：:To determine whether a sex difference exists in the biosynthetic capacity of vasopressingergic (AVP) neurons in the bed nucleus of the stria terminalis (BNST), we have used in situ hybridization and quantitative autoradiography to measure propressophysin messenger RNA levels in these cells from adult male and female r...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90152-6
更新日期：1989-05-01 00:00:00
abstract：:We investigated the effect of synthetic antimicrobial decapeptide KSL-W (KKVVFWVKFK) on normal human gingival fibroblast growth, migration, collagen gel contraction, and α-smooth muscle actin protein expression. Results show that in addition to promoting fibroblast adhesion by increasing F-actin production, peptide KS...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2017.05.003
更新日期：2017-07-01 00:00:00
abstract：:Huwentoxin-I (HWTX-I) is a 33-residue peptide isolated from the venom of Ornithoctonus huwena and could inhibit TTX-sensitive voltage-gated sodium channels and N-type calcium channels in mammalian dorsal root ganglion (DRG) neurons. However, the effects of HWTX-I on mammalian central neuronal and insect sodium channel...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.10.029
更新日期：2012-03-01 00:00:00
abstract：:The major amyloid-beta (Abeta) peptides found in the brain of familial and late onset Alzheimer's disease include the full-length Abeta1-42 and N-terminally truncated, pyroglutamylated peptides Abetap3-42 and Abetap11-42. The biophysical properties of Abeta1-42 have been extensively studied, yet little is known about ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2009.01.027
更新日期：2009-05-01 00:00:00
abstract：:The presence of the proenkephalin A-derived peptide Met5-enkephalin-Arg6-Gly7-Leu8 was demonstrated throughout the human gastrointestinal tract. Highest concentrations of Met5-enkephalin-Arg6-Gly7-Leu8, as assessed by radioimmunoassay, were measured in the separated muscularis externa, while lower levels were found in...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(86)90087-2
更新日期：1986-09-01 00:00:00
abstract：:We examined the mechanism through which leptin increases Na(+), K(+)-ATPase activity in the rat kidney. Leptin was infused under anaesthesia into the abdominal aorta proximally to the renal arteries and then Na(+), K(+)-ATPase activity was measured in the renal cortex and medulla. Leptin (1mug/kgmin) increased Na(+), ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2006.08.010
更新日期：2006-12-01 00:00:00
abstract：:Obestatin is a recently discovered peptide hormone that appears to be involved in reducing food intake, gut motility and body weight. Obestatin is a product of the preproghrelin gene and appears to oppose several physiological actions of ghrelin. This study investigated the acute effects of obestatin (1-23) and the tr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.02.003
更新日期：2007-05-01 00:00:00
abstract：:The oligopeptide transporter (PepT1) is located on the brush-border membrane of the intestinal epithelium which has been regarded as a mediator of protein absorption. Here, we cloned and characterized PepT1 genes from diploid (red crucian carp), triploid and tetraploid fish. Then, the PepT1 expression pattern in diffe...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.12.017
更新日期：2014-02-01 00:00:00
abstract：:Broad-spectrum antiviral drugs are urgently needed to treat individuals infected with new and re-emerging viruses, or with viruses that have developed resistance to antiviral therapies. Mammalian natural host defense peptides (mNHP) are short, usually cationic, peptides that have direct antimicrobial activity, and whi...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2013.07.014
更新日期：2013-10-01 00:00:00
abstract：:The secretin receptor is a member of a large family of G-protein-coupled receptors that recognize polypeptide hormone and/or neuropeptides. Charged, conserved residues might play a key role in their function, either by interacting with the ligand or by stabilizing the receptor structure. Of the four charged amino acid...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00122-9
更新日期：1999-01-01 00:00:00
abstract：:In this study, antimicrobial peptide S-thanatin (Ts) was chemically synthesized and linked to keyhole limpet hemocyanin (KLH) and bovine serum albumin (BSA) by carbodiimide reagent. Rabbits were immunized with Ts-KLH and polyclonal antibody against Ts was purified by fractional precipitation of ammonium sulfate, coupl...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.05.009
更新日期：2011-07-01 00:00:00
abstract：:A 20-kDa protein with substantial N-terminal sequence homology to thaumatin-like proteins was isolated from ripe fruits of the emperor banana, Musa basjoo cv. 'emperor banana'. The isolation procedure entailed (NH(4))(2)SO(4) precipitation, ion exchange chromatography on DEAE-cellulose, and affinity chromatography on ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.01.005
更新日期：2007-04-01 00:00:00
abstract：:Leptin, a hormone secreted by the adipocytes and involved in feeding and energy balance control, has been proposed to modulate alcohol craving in mice and humans. This study evaluated whether leptin modulates alcohol intake in Marchigian Sardinian alcohol-preferring (msP) rats. Rats were offered 10% ethanol either 2h ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2003.09.008
更新日期：2003-09-01 00:00:00
abstract：:The presence of immunoreactive porcine brain natriuretic peptide in rat tissues was studied with a specific radioimmunoassay for porcine brain natriuretic peptide-26. The cross-reactivity of the antiserum used was less than 0.001% with rat atrial natriuretic peptide, rat brain natriuretic peptide-32 and rat brain natr...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(91)90216-c
更新日期：1991-11-01 00:00:00
abstract：:We measured the concentration of beta-endorphin (beta-End) in plasma, as well as in aqueous humor and crystalline lens removed during cataract surgery. beta-End was detected both in the aqueous humor and in the crystalline lens. The concentration of beta-End in the aqueous humor corresponded to almost the half of the ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(01)00379-5
更新日期：2001-04-01 00:00:00
abstract：:The localization of endozepine-like immunoreactivity in the brain of the frog Rana ridibunda was investigated by indirect immunofluorescence, using an antiserum against synthetic rat octadecaneuropeptide (ODN). A specific immunoreaction was detected in ependymal cells lining the ventricular system of the brain and in ...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(92)90146-t
更新日期：1992-01-01 00:00:00
abstract：:We have cloned melanocortin receptors (MCRs) from several species of fish. The MC4R and MC5R subtypes arose early in vertebrate evolution and their primary structure is remarkably conserved. Expression and pharmacological characterization of the MCRs in fish has revealed that they bind and respond to melanocortin pept...
journal_title：Peptides
pub_type： 杂志文章,评审
doi：10.1016/j.peptides.2004.11.034
更新日期：2005-10-01 00:00:00
abstract：:The cholecystokinin receptor-type 1 (CCK1R) is a G-protein coupled receptor localized in the animal gastrointestinal tract. Receptor activation by the natural peptide ligand CCK leads to a feeling of satiety. In this study, hydrolysates from soy and milk proteins were evaluated for their potential to activate the CCK1...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2011.11.019
更新日期：2012-03-01 00:00:00
abstract：:I.c.v. injection for 9 days of either naltexone (NTX) (5, 10, 20, 40 micrograms/rat) or a selective mu peptide (CTOP) (0.125, 0.25, 0.5, 1, 3, 6 micrograms/rat) or delta (naltrindole) (NLT) (5, 10, 20 micrograms/rat) subtype opioid receptor antagonist affected sensitization to cocaine (COC) (50 mg/kg, i.p.) administer...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(97)00182-4
更新日期：1997-01-01 00:00:00
abstract：:This study evaluated the physiological importance of Angiotensin-(1-7) receptor Mas on reflex control of circulation. Experiments were performed in male Mas-knockout (Mas-KO) and Wild Type (WT) conscious mice (12-20 wk of age). Baroreceptor reflex was evaluated by the bradycardic response induced by phenylephrine (0.2...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2010.06.030
更新日期：2010-10-01 00:00:00
abstract：:The effects of amiloride on ANF binding and ANF stimulation of cGMP were evaluated in rat glomeruli. Amiloride increased ANF binding to whole glomeruli and to glomerular membrane preparations. In contrast, amiloride enhanced ANF-stimulated cGMP accumulation only at 37 degrees C in whole glomeruli, but not at 4 degrees...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/0196-9781(89)90145-9
更新日期：1989-05-01 00:00:00
abstract：:By using specific antibodies and radioimmunological and immunohistochemical methods, we here show that neuropeptide FF (NPFF) occurs in cervical and lumbar dorsal root ganglia cells. Levels in the ganglia were low because they were detectable only after colchicine treatment or after unilateral dorsal rhizotomy. Simila...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/s0196-9781(99)00039-x
更新日期：1999-01-01 00:00:00
abstract：:Despite the high impact of the antimicrobial peptide hepcidin in iron homeostasis, the regulation of this hormone is still not completely understood. Studies concerning hepcidin regulation are performed at the mRNA level. For the first time we analyzed the regulation of hepcidin not only at mRNA, but also at protein l...
journal_title：Peptides
pub_type： 杂志文章
doi：10.1016/j.peptides.2007.01.016
更新日期：2007-05-01 00:00:00
