Abstract:
:Leptin, a hormone secreted by the adipocytes and involved in feeding and energy balance control, has been proposed to modulate alcohol craving in mice and humans. This study evaluated whether leptin modulates alcohol intake in Marchigian Sardinian alcohol-preferring (msP) rats. Rats were offered 10% ethanol either 2h per day at the beginning of dark period of the 12:12h light/dark cycle, or 24h per day. Leptin was injected into the lateral ventricle (LV), the third ventricle (3V), or intraperitoneally (IP) once a day, 1h before the onset of the dark period. Neither acute nor chronic (9 days) leptin injections (1 or 8microg per rat) into the LV or 3V modified ethanol intake in male msP rats, offered ethanol 2h per day. Chronic LV injection of leptin (8 or 32 microg per rat in male rats and 8 or 16 microg per rat in female rats for 7 days), or chronic IP injections of leptin (1mg/kg in male rats for 5 days) failed to modify the intake of ethanol, offered 24h per day. Finally, chronic LV leptin injections (8 or 32 microg per rat for 12 days) did not modify ethanol intake in male msP rats, adapted to ad libitum access to ethanol and then tested after a 6-day period of ethanol deprivation. In contrast, in most of these conditions leptin significantly reduced food intake. These data do not support a role for leptin in alcohol intake, preference, or craving in msP rats.
journal_name
Peptidesjournal_title
Peptidesauthors
Polidori C,Luciani F,Fedeli A,Geary N,Massi Mdoi
10.1016/j.peptides.2003.09.008subject
Has Abstractpub_date
2003-09-01 00:00:00pages
1441-4issue
9eissn
0196-9781issn
1873-5169pii
S0196978103002869journal_volume
24pub_type
杂志文章相关文献
PEPTIDES文献大全abstract::CART (cocaine- and amphetamine-regulated transcript) peptides are neuropeptides abundant in the central nervous system and periphery found to be involved in the regulation of food intake behavior and other physiological processes. Recently, we reported specific binding of (125)I-CART(61-102) to the rat adrenal pheochr...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.07.022
更新日期:2007-10-01 00:00:00
abstract::Medium conditioned by a highly enriched population of gonadotrophs, cultured as reaggregates in the presence of 0.01 nM GnRH, was concentrated, separated on a reversed-phase HPLC column, and tested for activity on lactotroph development in pituitary reaggregate cell cultures of 14-day-old rats. The number of cells exp...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(96)00175-1
更新日期:1996-01-01 00:00:00
abstract::Osmotic stress stimulates the release of the avian hypothalamic neuropeptide arginine vasotocin (AVT) into the peripheral circulation. We conducted the present study to investigate the effects of salt-loading on AVT secretion and AVT gene expression in specific hypothalamic nuclei in chickens. White Leghorn chickens w...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00190-3
更新日期:1997-01-01 00:00:00
abstract::Venoms from cone snails (genus Conus) can be seen as an untapped cocktail of biologically active compounds, being increasingly recognized as an emerging source of peptide-based therapeutics. Cone snails are considered to be specialized predators that have evolved the most sophisticated peptide chemistry and neuropharm...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2012.07.002
更新日期:2013-03-01 00:00:00
abstract::The effects of proadrenomedullin N-terminal 20 peptide (PAMP) and adrenotensin (ADT) on adrenomedullin (ADM)-induced vasodilation were investigated in aortic rings from rat. ADM (10(-9) to 10(-7)M) relaxed the aorta preconstricted with phenylephrine in a concentration-dependent manner. Denudation of endothelium or pre...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(03)00109-8
更新日期:2003-04-01 00:00:00
abstract::The effect of EGF on the incorporation of [3H]TdR into DNA (DNA synthesis) was determined in the esophagus, liver, pancreas, and kidney in mice standardized to 12 hours (hr) of light alternating with 12 hr of darkness. A question asked was whether intraperitoneally administered EGF could alter the circadian patterns o...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(87)90110-0
更新日期:1987-03-01 00:00:00
abstract::This study evaluated the physiological importance of Angiotensin-(1-7) receptor Mas on reflex control of circulation. Experiments were performed in male Mas-knockout (Mas-KO) and Wild Type (WT) conscious mice (12-20 wk of age). Baroreceptor reflex was evaluated by the bradycardic response induced by phenylephrine (0.2...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.06.030
更新日期:2010-10-01 00:00:00
abstract::Multiple-time regression analysis has been used to study the influx of radiolabeled peptides and polypeptides across the blood-brain barrier (BBB). This study used both tritiated and iodinated leptin to clarify several issues associated with these measurements. Recombinant murine leptin was radiolabeled with 3H by der...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00569-1
更新日期:2001-12-01 00:00:00
abstract::Although previous studies have implicated NPY in the etiology of experimental cancer anorexia, the results have been difficult to interpret. Studies have suggested that although NPY level and message were decreased in the dorsomedial hypothalamic area (DMA), they were elevated in the ventromedial hypothalamic area (VM...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2006.10.018
更新日期:2007-02-01 00:00:00
abstract::The hypocretins (1 and 2) have emerged as key regulators of sleep and wakefulness. We developed a high-throughput enzyme immunoassay (EIA) to measure total brain hypocretin levels from large numbers of mice. Hypocretin levels were not altered by circadian time or age. However, significant differences in one or both hy...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(02)00251-6
更新日期:2002-12-01 00:00:00
abstract::The presence of immunoreactive endothelin (IR-ET) in human saliva and rat parotid gland was investigated by radioimmunoassay. The IR-ET concentration (mean +/- SEM) in saliva taken from normal volunteers was 2.0 +/- 0.2 pmol/l (n = 15). The IR-ET concentration in rat parotid gland was 19.2 +/- 2.2 fmol/g wet weight (n...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90151-e
更新日期:1991-07-01 00:00:00
abstract::The effects of acute and subchronic administration of chlordiazepoxide (CDZ) on [3H][3-methyl-histidyl2]thyrotropin-releasing hormone binding to thyrotropin-releasing hormone (TRH) receptors in membrane preparations from various regions of rat brain were examined. Acute administration of CDZ (50 mg/kg x 3 within 24 h)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(91)90188-u
更新日期:1991-01-01 00:00:00
abstract::Atriopeptins are circulating peptide hormones which are secreted by atrial tissue and act at the kidney. Because the atriopeptins survive passage through the pulmonary circulation, they also may be involved in the modulation of airway or pulmonary vascular smooth muscle tone. Using in vitro organ bath techniques, atri...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90159-7
更新日期:1985-07-01 00:00:00
abstract::HP-1 is the most abundant human representative of a recently discovered class of neutrophil cystine- and arginine-rich peptides. These peptides have many potentially regulatory activities expressed at nanomolar concentrations. To establish the levels of HP-1 that can accumulate in human lung tumors and nondiseased lun...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(92)90152-s
更新日期:1992-01-01 00:00:00
abstract::In situ hybridization techniques have been developed that quantitate the relative levels of specific mRNAs in individual cell types of a heterogeneous tissue, the mammalian brain. Here, we discuss those special procedures and precautions necessary for hybridizing radiolabeled probes to developing and adult brain mRNAs...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(85)90139-1
更新日期:1985-01-01 00:00:00
abstract::It has been proved that input of specific electroacupuncture (EA) can activate beta-endorphin(beta-EP)ergic and noradrenergic neurons projecting to the rostral ventrolateral medulla (RVL), the latter acting upon the RVL-GABAergic interneurons, thereby produce depressor effect. The present study further shows that: (1)...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(01)00467-3
更新日期:2001-09-01 00:00:00
abstract::Energy homeostasis is controlled by a complex neuroendocrine system consisting of peripheral signals like leptin and central signals, in particular, neuropeptides. Several neuropeptides with anorexigenic (POMC, CART, and CRH) as well as orexigenic (NPY, AgRP, and MCH) actions are involved in this complex (partly redun...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/s0196-9781(02)00269-3
更新日期:2002-12-01 00:00:00
abstract::Higher levels of natriuretic peptides were identified in outpatients after myocardial infarction (MI) compared to the healthy population, even in the absence of heart failure (HF). Therefore, we assessed the optimal cut-off value of B-type natriuretic peptide (BNP) in relation to new-onset HF prediction in 79 post-MI ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2010.06.023
更新日期:2010-10-01 00:00:00
abstract::Suppression subtractive hybridization comparing brains from diapausing and nondiapausing pupae of the flesh fly, Sarcophaga crassipalpis, suggested that the gene encoding neuropeptide-like precursor 4 (Nplp4) was uniquely expressed during diapause. We have sequenced the full-length cDNA encoding Nplp4 and used Norther...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2008.10.008
更新日期:2009-03-01 00:00:00
abstract::Urotensin II (U-II) is a vasoactive peptide with many potent effects in the cardiorenovascular system. U-II activates a G-protein-coupled receptor termed UT. UT and U-II are highly expressed in the cardiovascular and renal system. Patients with various cardiovascular diseases show high U-II plasma levels. It was demon...
journal_title:Peptides
pub_type: 杂志文章,评审
doi:10.1016/j.peptides.2007.08.029
更新日期:2008-05-01 00:00:00
abstract::Exposure of guinea pigs to the elevated plus maze (X-maze), an animal model of anxiety, causes an increase of extracellular serotonin (5-HT) in the lateral prefrontal cortex monitored by microdialysis. The neuropeptide cholecystokinin (CCK) plays a role in the modulation of anxiety. To compare the roles of CCK recepto...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00454-3
更新日期:1998-01-01 00:00:00
abstract::The role of central neuropeptide Y (NPY) in the cardiovascular response to social stress was evaluated in freely moving rats using telemetry. In unstressed rats, intracerebroventricular (ICV) administration of NPY and the selective Y1 receptor agonist [Leu31, Pro34]-NPY decreased blood pressure and heart rate, while t...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(97)00266-0
更新日期:1998-01-01 00:00:00
abstract:BACKGROUND:Visfatin is a novel adipokine and proinflammatory cytokine which is implicated in breast cancer progression. The exact proliferative and anti-apoptotic mechanisms of visfatin are still under debate. In this study, the effect of extracellular visfatin on proliferation and apoptosis of breast cancer cells were...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2017.04.007
更新日期:2017-06-01 00:00:00
abstract::[125I]beta-endorphin bound to high affinity (Kd = 0.25 nM) receptors in the caudal dorsomedial medulla of rats with a Bmax of 97 fmol/mg protein. The relative potency for displacement of [125I]beta-endorphin binding was: beta-endorphin(1-31) > beta-endorphin(1-27) > DAMGO > naloxone > N-acetyl-beta-endorphin(1-31) > U...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/s0196-9781(98)00024-2
更新日期:1998-01-01 00:00:00
abstract::We have developed a specific and sensitive radioimmunoassay for the hydra head activator neuropeptide (HHAP). The antibody recognizes the C-terminal portion of HHAP and shows no cross-reactivity with other neuropeptides. The assay allows measurement of HHAP-like material in tissue extracts with a minimum detectable co...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90081-f
更新日期:1990-03-01 00:00:00
abstract::Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear. Therefore, we investigated the function of these neuropeptides and th...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2013.03.003
更新日期:2013-05-01 00:00:00
abstract::The UII and urotensin II-related peptide (URP) genes belong to the same superfamily as the somatostatin gene. It has been previously shown that somatostatin activates the UII-receptor (UTR). In contrast, the possible interaction between UII and URP and somatostatin receptors has remained scarcely analyzed. Herein, we ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2007.12.015
更新日期:2008-05-01 00:00:00
abstract::Mastoparan (MP) peptides, distributed in insect venoms, induce a local inflammatory response post envenomation. Most endogenous MPs share common structural elements within a tetradecapeptide sequence that adopts an amphipathic helix whilst traversing biological membranes and when bound to an intracellular protein targ...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/j.peptides.2018.01.007
更新日期:2018-03-01 00:00:00
abstract::The involvement of the hypothalamic beta-endorphinergic system in behavioral processes has previously been studied in adult rats. In the present report, we studied the effects of undernutrition and of inhibitory avoidance training on the hypothalamic beta-endorphin-like immunoreactivity of 21-day-old and adult rats. R...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(88)90117-9
更新日期:1988-07-01 00:00:00
abstract::Bombesin (BBS) at doses of 0.1, 1.0, 10.0 and 100.0 nM stimulated chemiluminescence (CL) production by phagocytic cells (monocytes, macrophages and polymorphonuclear leucocytes) in mice in the presence of ZAP (opsonized zymosan particles containing luminol). These data suggest that BBS increased the phagocytic functio...
journal_title:Peptides
pub_type: 杂志文章
doi:10.1016/0196-9781(90)90098-p
更新日期:1990-03-01 00:00:00